Nationals vs. Giants Prediction, MLB Picks for Wednesday, June 10

The Washington Nationals vs. San Francisco Giants game is set to get underway at 3:45 p.m. ET on Wednesday, June 10, with the Giants returning a 1.78x payout on PrizePicks Team Picks if they win the matchup.

The Nationals were victorious in the opening two games of the series, including a 6-3 win on Tuesday night. Washington will look to complete the sweep in this affair on Wednesday afternoon.

Below, we'll break down our Nationals vs. Giants prediction and picks for Wednesday’s MLB game, including the spread, over/under, and key player picks for PrizePicks.

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Nationals vs. Giants Prediction, Winner Payout, Over/Under – Wednesday, June 10

In Wednesday’s series finale, Giants SP Robbie Ray (4.80 xFIP across 67.2 innings) and Nationals SP Foster Griffin (3.86 xFIP in 72.0 innings) will go head-to-head on the mound.

Ray has had his fair share of struggles, allowing 14 earned runs across his last four starts. The veteran left-hander has recorded a 5.07 xERA, which ranks in the 16th percentile.

On the other hand, Griffin has been one of Washington’s more successful arms. He leads the Nationals in wins (7) while also allowing one or fewer runs in two of his last three starts.

The Nationals have been one of the hottest hitting teams, ranking sixth in the majors in wRC+ (107). Meanwhile, the Giants are 13th in wRC+ (102) despite struggling to push runs across at times.

The Nationals have outscored the Giants 10-6 in the opening two games of the series. In Tuesday’s triumph, Washington’s bullpen shut the door with 5.0 innings of relief in which they only surrendered 1 earned run on 4 hits.

Nationals vs. Giants Winner Payout, Over/Under – Wednesday, June 10

The Giants enter Wednesday's game as a home favorite against the Nationals, returning a 1.78x payout if they win outright via PrizePicks Team Picks.

Here are the full payouts for the Nationals vs. Giants game on PrizePicks.

• Spread: San Francisco Giants -1.5 (2.63x payout)
• Over/Under: 8.5 (1.81x payout on Over)
• Game Winner Payout: Nationals 1.96x | Giants 1.78x

Play the Nationals vs. Giants winner or over/under on PrizePicks Team Picks to earn real money — available in 35 states!

Team Picks data is live at the time of writing and is subject to change.

Nationals vs. Giants Prediction on Winner – 6/10/26

Here are the key game stats and trends behind our Nationals vs. Giants prediction on the winner for Wednesday, June 10.

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• The Nationals are 5-2 in their last seven meetings against the Giants, including winning the last four road matchups.
• According to Baseball Savant, Ray has a fastball velocity of 93.2 mph, which ranks in the 27th percentile among MLB pitchers.
• In his professional career, Ray has a 3-6 record to go along with a 5.13 ERA and 59 strikeouts in 10 career starts against the Nationals. He's lost six of those starts.
• Washington leads the majors in runs (362), while San Francisco ranks 22nd in that department with 278.
• Griffin has showcased great command in 2026, as he’s recorded just a 7.1% walk rate (72nd percentile). Meanwhile, the Giants own the league’s lowest walk rate (6.0%), according to FanGraphs.
• Washington has outscored San Francisco 22-8 in the last four meetings in San Francisco.

Nationals vs. Giants Picks, Player Stats for PrizePicks: 6/10/26

Here are the top Nationals vs. Giants picks to target on PrizePicks for Wednesday, June 10. Today’s MLB picks for PrizePicks include Nationals OF James Wood and Giants SP Robbie Ray.

Nationals OF James Wood vs. Giants: 7.5 Hitter Fantasy Score

• Wood is hitting .444 (4-for-9) with an RBI in the first two games of the series.
• Wood has recorded a 25.2% barrel rate, which ranks in the 100th percentile.
• The Nationals’ slugger has recorded at least a hit in four of his last five contests.
• Per FanGraphs, Wood has tallied a .373 BABIP against left-handed pitching, which is 15 points better than his .358 BABIP against righties on the year.

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Giants SP Robbie Ray vs. Nationals: 5 Strikeouts

• Ray has registered 4 or fewer strikeouts in four of his last five starts.
• The Nationals rank 19th in the majors with a 19.4% strikeout rate.
• The Giants’ veteran pitcher has produced a 21.7% K-rate in 2026, ranking in the 45th percentile.
• Ray is surrendering a 36.6% hard-hit clip, which ranks in the 63rd percentile among MLB pitchers.

Add Robbie Ray to your PrizePicks Lineup now.

Make Nationals vs. Giants Picks on PrizePicks

The Nationals have come out on top in the opening two games of the series. Can the Nationals secure the sweep on Wednesday afternoon in this National League showdown?

Don’t wait until first pitch — make your Nationals vs. Giants picks on PrizePicks now and earn real money if you’re right.

Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 35 states.

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