Lions vs. Chiefs Prediction, Sunday Night Football Picks: Jared Goff Dominance?

The Lions and Chiefs meet in a matchup of two teams some predicted to play in the Super Bowl. The Chiefs look to get back to .500 after last week’s last-gasp loss to the Jaguars, while the Lions aim to stay on top of the NFC. The Sunday night game kicks off at 8:20 p.m. ET on NBC.

Below, we'll break down our Lions vs. Chiefs prediction and Week 6 Sunday picks, including the top player picks on PrizePicks real money NFL game, including Lions QB Jared Goff and WR Amon-Ra St. Brown, and Chiefs QB Patrick Mahomes.

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Lions vs. Chiefs Prediction, Week 6 Picks

Detroit Lions Preview

• The Lions lead the NFL in points per game, averaging 34.8. They've hit 34+ points in each of their last four outings. 
• The Motor City denizens scored 30+ points in 10 of the last 11 contests, dating back to last season.
• Detroit’s offense ranks fourth in DVOA, per FTN Fantasy. 
• Just as impressive, the Lions defense ranks second in DVOA, behind only the Falcons. 

Kansas City Chiefs Preview

• During the 2023 and 2024 seasons, the Chiefs won an NFL-record 17 consecutive one-score games. This season, the Chiefs are 0-3 in one-score games.
• After averaging 315.6 yards per game the first three contests of the season, K.C. has averaged 429.0 yards of offense in the last two, coinciding with WR Xavier Worthy’s return to the lineup.
• The Chiefs enter with a 2-3 record. The last time they were 2-4 or worse was in 2015 (1-5), when QB Patrick Mahomes was a sophomore at Texas Tech. 
• K.C.'s coverage defense is second-best in the NFL per PFF, rated 76.9, just behind the Jaguars. 

Lions vs. Chiefs Picks for NFL DFS & PrizePicks

Here are three Lions vs. Chiefs player picks for Week 6 for PrizePicks real money NFL game, including Lions QB Jared Goff and WR Amon-Ra St. Brown, and Chiefs QB Patrick Mahomes.  

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Lions QB Jared Goff Projection vs. Chiefs: 240.5 passing yards

• Lions QB Jared Goff leads the NFL with 12 TD passes and a 120.7 passer rating through five games. 
• He's tenth in the league in passing yards, averaging 237.4 per game.
• Goff’s 70.7 QBR (ESPN metric) ranks seventh among all QBs.
• Goff has thrown for 200+ yards in 14 of the last 15 games, including four of five this season. 

Lions WR Amon-Ra St. Brown Projection vs. Chiefs: 6.5 receptions

• Lions WR Amon-Ra St. Brown has had 6+ targets in 16 consecutive games, including the postseason.
• The Lions wideout has 6+ receptions in nine of his last ten games, dating back to last season. 
• St. Brown’s 28.1% team target share ranks sixth in the NFL. 
• The former USC standout has 6 receiving TDs, the most in the NFL. He finished last season third in the league with 12 receiving TDs. 

Chiefs QB Patrick Mahomes Projection vs. Lions: 29.5 rushing yards 

• Dating back to last season, Chiefs QB Patrick Mahomes has multiple TD passes in only two of his last eight games, including only once this season. 
• Prior to that, Mahomes had thrown 2+ passing TDs in 10 of 20 games. 
• Mahomes enters Week 6 as the Chiefs leading rusher with 190 rushing yards.
• The two-time MVP has recorded 50+ rushing yards in three of five games this season.

Make Week 6 Football Picks on PrizePicks

Will the Chiefs get back to .500 after the tough Week 5 loss on Monday night vs. the Jaguars? Or will the Lions move to 5-1 and put Chiefs Kingdom on notice?

As the NFL season enters its sixth week, there's no better place to get real money action with your NFL predictions than on PrizePicks.

There is a wide variety of player stat projections on the NFL board, so you can make predictions on whatever you'd like — from yards to field goals. Just pick at least two players and pick More or Less on their stats to build your Lineup on PrizePicks.

Check out the Playbook throughout the NFL season for more NFL predictions for your PrizePicks and NFL DFS Lineups.