The thriving Los Angeles Lakers (23-11) are riding a 4-1 stretch, highlighted by Tuesday’s road win against the New Orleans Pelicans. On the other hand, the San Antonio Spurs have landed in the loss column in consecutive games, including falling to the Memphis Grizzlies on Tuesday.
Two of the top three teams in the Western Conference go head-to-head on Wednesday night at the Frost Bank Center in San Antonio. The game tips at 9:30 p.m. ET on ESPN.
Below, we'll preview the game and offer a Lakers vs. Spurs prediction and picks on PrizePicks , including player projections for C Victor Wembanyama and F LeBron James.
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Lakers vs. Spurs Prediction, Spread, Over/Under
After missing the playoffs for the sixth consecutive season in 2024-25, the Spurs look poised to make a return to the promised land. Entering Wednesday, San Antonio sits in second place in the West and trails the Oklahoma City Thunder by 4.5 games.
The Spurs are going through a bit of a rough patch with four losses in their last six games, but remain one of the NBA’s top offenses. San Antonio is averaging 119.7 points per game (sixth in the NBA), while connecting on 48.0% of its shots, eighth in the league.
As should come as no surprise, the Spurs are paced by C Victor Wembanyama, who is averaging 24.3 points, 11.7 rebounds, and 2.9 blocks per contest. Wemby has recently thrived despite playing limited minutes as he has logged 28 minutes or less in every game since returning from a calf strain in mid-December. He also missed two games due to a knee injury before returning on Tuesday.
San Antonio will be without G Devin Vassell for Wednesday’s game as he deals with a left adductor strain. There is currently no timetable for his return.
Meanwhile, the Lakers are riding a three-game winning streak, capped by a 111-103 dub vs. the Pelicans on Tuesday. Los Angeles sits in third place in the West, one game behind the Spurs.
The New Year has been kind to Lakers G Luka Doncic thus far. In three games in January, Doncic is averaging 33.3 points, 8.7 rebounds, and 5.7 assists despite shooting just 29.6% from beyond the arc. It also hasn’t hurt that James is on a heater of his own, posting 29.0 points per contest during the team’s three-game winning streak.
The biggest issues for Los Angeles has proved to be on the defensive end of the floor. The Lakers surrender 117.3 points per contest (18th in the NBA) while allowing opponents to shoot 37.7% from three (second-worst in the league).
The Lakers will continue to be without G Austin Reaves, who is currently nursing a calf injury. F Rui Hachimura (calf) will remain out of the lineup in addition to G Gabe Vincent, who is dealing with a back injury.
Lakers vs. Spurs Over/Under, Spread
The Spurs are 7.5-point favorites, returning a 1.33x payout on PrizePicks Team Picks if they win outright.
The Lakers will return a 3.03x payout on PrizePicks Team Picks if they win outright.
- Spread: San Antonio Spurs -7.5
- Over/Under: 236.5
- Gamer Winner Payout: Lakers 3.03x | Spurs 1.33x
Team picks data is live as of publishing and is subject to change.
Lakers vs. Spurs Prediction on Spread
Here are some stats to know to get you prepared for Lakers vs. Spurs today.
- The Spurs are 9-7-1 against the spread at home.
- Los Angeles is 11-7 against the spread on the road.
- San Antonio is 7-7-1 against the spread as a home favorite.
Lakers vs. Spurs Picks
Here are some of the top Lakers vs. Spurs picks on PrizePicks for today. Player projections are via the PrizePicks real-money NBA game.
Spurs C Victor Wembanyama vs. Lakers Projection: 34.5 PRA
- Wembanyama has averaged 40.0 points, rebounds, and assists in his last five games.
- The Spurs center registers 32.0 true shots attempts per 100 possessions, per databallr, ranking him in the 99th percentile.
- The French sensation tallies 10.8 potential assists per 100 possessions, per databallr. That ranks him in the 90th percentile.
- Per NBA.com, the MVP candidate secures 37.5% of contested rebounds.
Lakers F LeBron James vs. Spurs Projection: 28.5 Pts+Asts
- The Lakers star averages 32.2 points and assists over his last five games.
- James registers 15.1 potential assists per 100 possessions, per databallr, placing him in the 90th percentile.
- The 2003 number-one pick is shooting 60.2% on two-point field goal attempts this season, per databallr. That ranks him in the 85th percentile.
- James spends 19.9% of his time on ball, per databallr, ranking him in the 79th percentile among NBA players.
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Make Lakers vs. Spurs Picks on PrizePicks
The Lakers are riding a three-game winning streak, while the Spurs have dropped back-to-back games. As a result, it makes Wednesday the perfect time to make your Lakers vs. Spurs picks at PrizePicks, where you can earn real-money rewards for your predictions if you’re right.
Just choose players — including Victor Wembanyama and LeBron James — predict More or Less on their projected stats, and follow the hoops action to see if your picks hit. You can make picks on winners, spreads, and over/unders on Team Picks, now available in 30 states.
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