Week 17 of the NFL slate features several divisional matchups, and Jaguars vs. Colts (1:00 p.m. ET on FOX) has a pair of AFC South foes going head-to-head.
The crowd at Lucas Oil Stadium sees the 8-7 hosts on the brink of being eliminated from playoff contention despite a 7-1 start to the year. The visiting Jaguars, meanwhile, have rattled off six wins in a row and are playing as well as just about any club.
Below, we’ll break down our Jaguars vs. Colts prediction and picks for Week 17. Use PrizePicks NFL to monitor player projections and make picks for real rewards if you’re right.
Jaguars vs. Colts Prediction, Spread, Over/Under
Sunday marks a milestone meeting: the 50th clash between the Jaguars and Colts. With Indianapolis holding a 28-21 series advantage, including four wins in the last five, they currently boast bragging rights over their in-division rivals.
The Colts welcome back CB Sauce Gardner this weekend, but star DT DeForest Buckner’s season is over due to an aggravation of his neck injury. For Jacksonville, RB Bhayshul Tuten (finger) carries a questionable designation into Sunday.
Jaguars vs. Colts Over/Under, Spread
The Jaguars enter Sunday’s game as 6.5-point road favorites, returning a 1.35x payout on PrizePicks Team Picks if they win outright.
The Colts are home underdogs with a 2.94x payout if they win, via PrizePicks Team Picks.
- Spread: Jacksonville Jaguars -6.5
- Over/Under: 47.5
- Game Winner Payout: Jaguars 1.35x | Colts 2.94x
Team Picks data is live at the time of writing and is subject to change.
Jaguars vs. Colts Prediction on Spread
Here are some stats to know to get you prepared for Jaguars vs. Colts.
- Dating back to 2020, the Colts have a 16-17-1 record against the spread in games versus division foes. Jacksonville is 16-18 in the same span.
- Jacksonville is 10-5 ATS overall this season, tied for the second-best record in the sport. Indianapolis is a solid 7-6-2.
- Under first-year head coach Liam Coen, the Jaguars have the seventh-ranked scoring offense and are sixth in points per drive on defense.
- The Colts remain second in points per drive on offense but are 18th on defense. Not only that, but head coach Shane Steichen’s group averages just 19.6 PPG since the bye.
Jaguars vs. Colts Week 17 Picks
Here are three Jaguars vs. Colts picks for Week 17’s Sunday showdown. Some top same-game PrizePicks projections to consider include QBs Trevor Lawrence and Philip Rivers and RB Jonathan Taylor.
Jaguars QB Trevor Lawrence vs. Colts Projection: 248.5 Pass Yards
- The fifth-year breakout might officially be here for Lawrence. He averages 232.6 passing yards per game but in his last five, that number is up to 267.6.
- According to SumerSports, Lawrence ranks 13th among all QBs with 48.69 total EPA.
- The Colts have allowed the fourth-most passing yards to the QB position (3,994) this season.
- In eight career games against Indianapolis, Lawrence is 6-2 with 13 passing TDs, 3 INTs, and a 104.5 passer rating.
Colts QB Philip Rivers vs. Jaguars Projection: 211.5 Pass Yards
- In two games since coming out of retirement, Rivers has racked up 397 passing yards with 3 TDs and 2 INTs.
- A staggering 95.5% of Rivers’ snaps have been taken from shotgun in two games, the highest rate since he made his 2025 debut.
- According to NFL Pro, 25 of Rivers’ 62 pass attempts have gone over the middle third of the field. Jacksonville surrenders the lowest yards per attempt (5.8) and explosive pass rate (11.3%) on such tries.
- The Jaguars yield the fourth-lowest EPA per pass average at -0.10, per SumerSports.
Colts RB Jonathan Taylor vs. Jaguars Projection: 96.5 Rush + Rec Yards
- Taylor averages an impressive 122.7 scrimmage yards per game on the year. In two contests with Rivers, however, that number is down to 90.
- Among 48 RBs with 100+ carries, Taylor’s percentage of runs stopped for a loss (7.99) ranks 30th. His target share is 16th in the same group.
- During the Colts’ five-game losing streak, Taylor averaged 3.7 yards against stacked boxes, via NFL Pro. The Jaguars loaded the box 48.4% of the time when these teams met in Week 14.
- Jacksonville has allowed the third-fewest fantasy points to the RB position in 2025. That includes the lowest rushing total by far (1,020 — the Patriots are second at 1,121).
Make Jaguars vs. Colts Picks on PrizePicks
When Jacksonville and Indianapolis duke it out, there will be plenty of opportunities for Jaguars vs. Colts picks. The NFL Week 17 slate also leaves the door open for several other player projections and much more.
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