The semifinals of the Big 12 Tournament see the Iowa State Cyclones (27-6) take on the Arizona Wildcats (30-2) in the T-Mobile Center in Kansas City, MO. Tip-off is set for 7:00 p.m. ET on ESPN, with Arizona favored by 4.5 points.
This is the second meeting of the season between these two teams, and it's the Cyclones who aim to even the score after suffering a 73-57 loss at the hands of these Wildcats just 11 days ago.
Who will have an advantage for Friday’s Iowa State vs. Arizona pick against the spread? Use PrizePicks Team Picks to make predictions on game winners, spreads, over/unders, and more.
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Iowa State vs. Arizona Prediction, Spread, Over/Under
It seemed as though Iowa State was stumbling down the stretch, losing three of its last four games to close out the regular season. They were able to quickly put that hiccup behind them, though, looking terrific to start the Big 12 Tournament.
The Cyclones kicked off the tourney with a beatdown of Arizona State, 91-42, and followed that up with a decisive 75-53 win over #16 Texas Tech. The win over Tech avenged a loss — in Ames, no less — from the end of the regular season.
The Wildcats have had a dominant season and look to continue that trend. Aside from a two-game stretch in mid-February that saw them suffer both of their losses, they've rolled through opponents with relative ease.
Arizona opened the Big 12 Tournament with a comfortable 81-59 win over UCF, with the star freshman duo of G Brayden Burries (21 pts) and F Koa Peat (12 points) leading the way again. Burries leads the Wildcats in PPG at 16.2, with Peat checking in right behind him at 13.7.
The Wildcats may need both young guns to continue playing like veterans if they want to make a deep run in this bracket. “Yes” on them to win the Big 12 Tournament is currently returning a 2.17x payout on PrizePicks Team Picks.
Iowa State vs. Arizona Spread, Over/Under
The Wildcats enter Friday’s game as 4.5-point favorites, returning a 1.51x payout on PrizePicks Team Picks if they win outright.
The Cyclones are the underdogs with a 2.38x payout if they win, via PrizePicks Team Picks, where you can earn money with your picks in 35 states.
- Spread: Arizona Wildcats -4.5 (1.88x payout)
- Over/Under: 143.5 (1.88x payout on over)
- Game Winner Payout: Cyclones 2.38x | Sun Devils 1.51x
Team Picks data is live as of writing and is subject to change.
Iowa State vs. Arizona Prediction on Spread – 3/13/26
Here are the key stats to know before locking in your Iowa State vs. Arizona prediction on the spread for Friday, March 13, on PrizePicks.
- Both of these teams have been among the best against the spread (ATS) in the Big 12, with the Cyclones sitting second at 19-13-1 (59.4%) and the Wildcats at 18-13-1 (58.1%).
- The Wildcats both won and covered in the lone meeting between these programs this season.
- According to KenPom, Arizona is third in the nation in net rating (+37.74), 5.54 points ahead of Iowa State in seventh (+32.26).
- Led by C Motiejus Krivas and PF Tobe Awaka, Arizona has been one of the most dominant offensive rebounding teams in all of college basketball, slotting in at fifth in offensive rebounding percentage at 38.3%.
- This could be a problem spot for an Iowa State team that ranks just 64th nationally in defensive rebounding percentage (27.9%).
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Make #7 Iowa State vs. #2 Arizona Picks on PrizePicks
Can Iowa State get revenge on Arizona for their loss earlier this season, or will the Wildcats continue their dominant ways with another quality win over a tough foe?
You can make your Iowa State vs. Arizona picks on PrizePicks and PrizePicks Team Picks to earn real money. Just pick players, predict More or Less on their projected stats, and cash in if you’re correct. With Team Picks, make predictions on winners, spreads, and over/unders, now available in 35 states.
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