One of college basketball’s most loaded conferences provides another high-profile matchup on Monday night, with the Iowa State Cyclones traveling to face the Arizona Wildcats.
The clash of top-10 programs tips off at 9:00 p.m. on ESPN. With the Big 12 tournament approaching, every moment of action carries plenty of importance in a battle of heavyweights.
Below, we’ll break down our Iowa State vs. Arizona prediction and picks for Monday's game. Make your college basketball picks on PrizePicks and PrizePicks Team Picks and earn real money if you’re right, including on game winners, spreads, and totals!
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Iowa State vs. Arizona Prediction, Spread, Over/Under
Head coach T.J. Otzelberger’s crew is pacing for its best season with him at the helm. Sitting at 24-5 on the year, Iowa State has ascended to premier status. With that said, Saturday saw the Cyclones drop a tough game to Texas Tech by a final score of 82-73.
Under Tommy Lloyd, Arizona is one of 2025-26’s best teams. The Wildcats have lost just twice all season long, both in conference play, and responded to those consecutive defeats by ripping off four wins in a row entering Monday. They own at least a share of the regular-season Big 12 title.
This Big Monday bout is the 10th time Iowa State and Arizona will have faced off since 1949-50. The Wildcats own a narrow 5-4 series lead, albeit with an average margin of victory of 0.9 points.
Iowa State vs. Arizona Spread, Over/Under
Iowa State enters Monday’s game as 7.5-point road underdogs, returning a 3.84x payout on PrizePicks Team Picks if they win outright.
Arizona is a home favorite with a 1.28x payout if they win, via PrizePicks Team Picks, where you can earn money with your picks in 34 states.
- Spread: Arizona Wildcats -7.5
- Over/Under: 147.5
- Game Winner Payout: Cyclones 3.84x | Wildcats 1.28x
Team Picks data is live at the time of writing and is subject to change.
Iowa State vs. Arizona Prediction on Spread
Here are the key stats to know before locking in your Iowa State vs. Arizona prediction on spread for Monday, March 2 on PrizePicks.
- Iowa State has covered in its lone opportunity as a road underdog, going 1-0 against the spread. Arizona is 7-8-1 ATS as home favorites.
- The Cyclones boast the sixth-best average scoring margin (+17.0), which stems from getting quality looks from deep (39.0%, eighth).
- On the other end, only a baker’s dozen teams can say they allow fewer PPG than ISU, who sits at 65.5.
- Arizona scores the 10th-most PPG in Division I (87.1), albeit with the 48th-ranked effective field goal percentage (54.9).
- The Wildcats’ defense is elite on the interior, yielding the second-lowest 2-point clip (43.6%).
Iowa State vs. Arizona Picks for PrizePicks Today: 3/2/26
Here are three top Iowa State vs. Arizona picks to target for Monday, March 2 on PrizePicks. Player stat projections via PrizePicks are headlined by F Joshua Jefferson, F Milan Momcilovic, and G Brayden Burries.
Iowa State F Joshua Jefferson vs. Arizona Projection: 28.5 Pts + Rebs + Asts
- Jefferson averages 29.4 combined points, rebounds, and assists (PRA) this year. In conference play, that number is 28.7.
- On a personal best 3.0 3-point attempts each night, the fourth-year man cans 36.8% of them. He shot just 31.0% last year.
- Per Bart Torvik, Jefferson ranks 11th among all qualified Big 12 players with a 20.4 defensive rebounding percentage.
- The senior’s 28.6% assist rate marks a collegiate career high, serving as a 9% increase year-over-year.
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Iowa State F Milan Momcilovic vs. Arizona Projection: 16 Points
- An absolute revelation for the Cyclones, Momcilovic puts up 17.4 PPG, including 17.1 against conference opponents.
- Momcilovic leads the nation in 3-point percentage (50.9), maintaining a red-hot 48.8% mark in Big 12 play.
- Over 1,000 Division I players can match the Wisconsin native’s usage rate of 18.6%, but he leads the field in offensive rating at 140.0.
- Arizona allows 23.0 3-point tries per game, ranking 178th in the country.
Arizona G Brayden Burries vs. Iowa State Projection: 23 Pts + Rebs + Asts
- Twenty-nine games into his debut campaign, Burries pours in 23.3 PRA. Since the start of conference play, his average is up to 26.3.
- Per CBB Shot Charts, Burries makes 67% of both his right-corner 3-pointers and rim attempts. Iowa State allows foes to make 44% and 61% of those attempts, respectively.
- A whopping 118 freshmen are 6-foot-4 or shorter. Burries ranks 11th with a 14.2% defensive rebounding rate.
- The Cyclones’ defense ranks 222nd in assists per made field goal with a 0.539 ratio.
Make #6 Iowa State vs. #2 Arizona Picks on PrizePicks
Iowa State vs. Arizona Big 12 picks are just one of many ways hoops fans can get in on the daily college basketball action.
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