Florida vs. Ole Miss Prediction, Saturday CFB Picks: DJ Lagway Comeback?

Florida and Ole Miss, on opposite sides of the SEC standings, meet for the 26th time on Saturday evening in Oxford, Mississippi. Ole Miss comes in perched at No. 7 in the country and squarely in position to earn a berth in the SEC title game and College Football Playoff. The Gators, meanwhile, need to win out to make a bowl game. The game is set to kick off at 7:00 p.m. ET on ESPN.

Florida interim coach Billy Gonzales, who took over for Billy Napier before a November 1 loss to Georgia, looks for his first head coaching win. The man on the other side of the field, former Raiders, Tennessee, and USC coach Lane Kiffin, has been mentioned as a possible head coaching candidate for the open Florida job.

The game will feature Florida QB DJ Lagway and Ole Miss signal caller Trinidad Chambliss behind center. We'll give you our Saturday Florida vs. Ole Miss prediction and CFB picks for PrizePicks, including Lagway and Chambliss player picks for PrizePicks' real money college football game.

Florida vs. Ole Miss Prediction, Preview for Week 12

Florida and Ole Miss meet for the second straight year after the Gators stunned ninth-ranked Rebels, 24-17, in The Swamp last season, ending the Rebels CFP hopes.

Florida leads the all-time series 13-12, and has won the last three in the series, including a 51-35 beatdown in Oxford in 2020. 

Florida Gators Preview

• After facing, and losing to 3-5 Kentucky, Florida is back to playing a top-ten team in seventh-ranked Ole Miss. The Rebels are the sixth top-10 team Florida has faced in the last eight games.
• Florida’s offense enters the week 116th of 136 FBS teams in scoring with 20.4 points per game. They rank 107th in total offensive yards, 105th in rushing offense, and 84th in passing offense. 
• On the other side, Florida’s defense has kept them in games. The Gators dropped from 32nd to 53rd in scoring defense, allowing 22.4 points per game. They are 49th in yards allowed and 46th in rush defense. 

Ole Miss Rebels Preview

• Ole Miss is 9-1 through 10 games for the first time since 1962, when they went 10-0 and finished No. 3 in the country. 
• The Rebels boast one of the top offenses in the nation, ranked fourth in FBS (tops in SEC) in yards per game at 489.4, seventh in passing offense (305.5), and 13th in scoring at 37.5 points per game. 
• Over on defense, Ole Miss is 18th against the pass and 24th in scoring with 19.8 points per game.
• The Rebels have won ten straight at home and have taken 20 of their last 21 at Vaught-Hemingway Stadium.

Florida vs. Ole Miss Picks for PrizePicks

Here are the player picks to target in PrizePicks real money college football game and in CFB DFS, including Florida QB DJ Lagway, Ole Miss QB Trinidad Chambliss, and RB Kewan Lacy.

Florida QB DJ Lagway Projection vs Ole Miss: 174.5 Pass Yards

• Florida QB DJ Lagway was benched in the second half of his last game, finishing with 83 passing yards, his second lowest total of the season (61 vs. Miami).
• Lagway has failed to reach 175 yards passing in four of nine games this season. 
• After throwing 5 TD passes in the first three games of the season, Lagway has tossed 6 TDs passes in six games since. 
• Lagway’s 125.02 passer rating is ranked 93rd among FBS QBs and 15th among 16 qualified SEC QBs. His 12 INTs are most in the nation. 

Ole Miss QB Trinidad Chambliss vs. Florida: 270.5 Pass Yards

• Ole Miss QB Trinidad Chambliss has passed for 250+ yards seven of his eight starts this season, including five games of 300+ yards. 
• Chambliss is a dual threat QB, gaining 40+ yards on the ground in six of his eight games. 
• The Ole Miss QB has a passer rating of 153.71, 29th in the nation and fifth in the SEC.
• Chambliss has 1+ passing TD in each of his eight starts since taking over for the injured Austin Simmons.

Ole Miss RB Kewan Lacy: 94.5 Rush Yards 

• Rebels RB Kewan Lacy has 912 rushing yards this season, second-most in the SEC and tenth in the country.
• Lacy has 16 rushing TDs, which leads both the SEC and the nation. 
• The Ole Miss back has 65+ rushing yards in seven of his ten games this season. 
• The sophomore's 91.2 rush yards per games is 22nd in the country. 

Florida looks to  finish the season on a strong note, while Ole Miss hopes to stay in the SEC title and CFP races.

No matter what your take on this Saturday evening’s matchup is, you can win real money with your Florida vs. Ole Miss predictions on PrizePicks while you watch.

Simply pick your players — from Lagway to Chambliss — predict More or Less on their projected stats, and win cash when you're right. It's that easy.