Both sitting near the top of their respective divisions, the Falcons and 49ers square off in the Bay Area for what could be a nifty Sunday Night Football clash, a matchup featuring two of the game's best all-around RBs in Bijan Robinson and Christian McCaffrey. The game kicks off at 8:20 p.m. ET on NBC
Below, we'll break down our Falcons vs. Niners prediction and Sunday Night Football picks, including the top player picks on PrizePicks real money NFL game, including Falcons RB Bijan Robinson and WR Drake London, and 49ers RB Christian McCaffrey.

Falcons vs. 49ers Prediction, Sunday Night Football Picks
If the Falcons beat the 4-2 49ers after beating the 4-1 Bills on back-to-back primetime games, I fear the vibes will reach dangerous levels
— Rise Up Bijan (@RiseUpReader) October 18, 2025
2016 levels, dare I say pic.twitter.com/jzCmiH8bKx
Atlanta Falcons Preview
- The Falcons defense leads the NFL in total defense, holding opponents to 253.1 yards per game. They also have the top passing defense at 139.4 pass yards per game.
- Per DVOA, the Falcons have the top defense in the NFL, ahead of Green Bay, Houston, and Seattle.
- On the offensive side, the Falcons lead the NFL in rushing yards per game at 151.2 and are second in overall yards at 378.8.
- Atlanta shoots for their second consecutive 4-2 start. Prior to last season, the Falcons last started 4-2 in 2016.
San Francisco 49ers Preview
- The Niners enter Week 6 averaging 291.5 pass yards per game, tops in the NFL.
- On the flip side, the 49ers rushing offense is 30th at 82.2 yards per game.
- QB Mac Jones will start for the third straight game and for the fifth time in seven games with Brock Purdy ruled out with a toe injury. However, Purdy did practice this week in a limited capacity.
- Purdy is not the only 49ers player battling injuries, as WR Ricky Pearsall and LB Fred Warner are also both out.
Falcons vs. 49ers Picks for NFL DFS & PrizePicks
Here are three Falcons vs. 49ers player picks for Week 7 for PrizePicks real money NFL game, including Falcons RB Bijan Robinson and WR Drake London and 49ers RB Christian McCaffrey.
Pick More or Less on these projections on PrizePicks — plus thousands more — to win real money this NFL season.
Falcons RB Bijan Robinson Projection vs. Niners: 78.5 rushing yards
Bijan Robinson. Best back in football.
— Carrie (@carrielynnxox) October 16, 2025
822 total yards from scrimmage (1st overall)
14.1 yards per reception (1st among RBs)
5.8 yards per carry (1st among RBs)
81-yard TD run (longest overall)
RB1. pic.twitter.com/yXqf29X06x
- After being held to 24 rushing yards in the season opener vs. the Buccaneers, Falcons RB Bijan Robinson has 70+ rushing yards in his last four games, including tying a career high with 170 rushing yards last week vs. the Bills.
- The Falcons RB is now third in the NFL with 484 rushing yards, which is 96.8 per game.
- Robinson has added 25+ receiving yards in all five games, hitting 100+ in two of the five games.
- The former Texas Longhorn is averaging 14.1 yards per catch, the most of any RB in football.
Falcons WR Drake London Projection vs. Niners: 71.5 receiving yards
One of two active @NFL duos to record 150+ scrimmage yards in multiple games
— Atlanta Falcons (@AtlantaFalcons) October 17, 2025
Bijan Robinson and Drake London 🔥 pic.twitter.com/gUJTdOPq9P
- Falcons WR Drake London recorded 158 yards receiving vs. the Bills in Week, his fourth career game with 150+ yards.
- Over the past two games, London has recorded 18 catches on 26 targets for 268 yards and 2 TDs.
- In eight games with Michael Penix Jr. at QB — last three games last season and all five games this season — London has 92 targets (11.5 per game, second in NFL), 56 receptions (7 per game, sixth in NFL), 779 receiving yards (97.4 per gamel fourth in NFL) and 4 TDs.
Niners RB Christian McCaffrey Projection vs. Falcons: 62.5 rushing yards
Most receiving yards through 6 weeks:
— NFL Stats (@NFL_Stats) October 15, 2025
Jaxon Smith-Njigba - 696
Puka Nacua - 616
George Pickens - 525
Emeka Egbuka - 469
Ja'Marr Chase - 468
Amon-Ra St. Brown - 452
Justin Jefferson - 449
Christian McCaffrey - 444
Drake London - 427
Zay Flowers - 423 pic.twitter.com/iyOktOoGcM
- McCaffrey has failed to top 70 rushing yards in any game this season.
- He recorded 79 in one of the four games last year, meaning he has no games of 80+ rush yards over the last two seasons.
- The do-it-all back has 6+ receptions and 7+ targets in all six games this season.
- This SNF matchup features the two RBs with the most receiving yards in the NFL this season in Robinson (second at 338) and McCaffrey (tops with 444)
Make Week 7 Football Picks on PrizePicks
Can the Falcons knock off the 49ers a week after shocking the Bills? Or will the 49ers rebound from last week’s L to the Buccaneers and keep pace in the loaded NFC West? The Falcons and Niners, both with only two losses on the season, meet in a marquee Week 7 Sunday Night Football game at 8:20 p.m. ET on NBC
As the NFL season enters its seventh week, there's no better place to get real money action with your NFL predictions than on PrizePicks.
There is a wide variety of player stat projections on the NFL board, so you can make predictions on whatever you'd like — from yards to field goals. Just pick at least two players and pick More or Less on their stats to build your Lineup on PrizePicks.
Check out the Playbook throughout the NFL season for more NFL predictions for your PrizePicks and NFL DFS Lineups.
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