Eagles vs. Packers Prediction, MNF Picks: Will Saquon Barkley Find His Groove?

NFL Week 10 concludes with the Eagles (6-2) heading to Lambeau Field in Green Bay to clash with the Packers (5-2-1) on Monday Night Football. With the matchup set to kick off at 8:15 p.m. ET on ESPN, it's time to break down our Eagles vs. Packers prediction and MNF picks for PrizePicks tonight.

This game features two first-place teams eyeballing playoff positioning. The Birds and the Pack met twice last season; with the Eagles taking a a 34-29 regular season victory, then again prevailing with a 22-10 playoff victory on their way to a Super Bowl Championship. 

Let’s see if Green Bay can get its revenge, as we bring you our Eagles vs. Packers picks, prediction, and the top PrizePicks projections, with an eye trained on Saquon Barkley.

Eagles vs. Packers Prediction, MNF Picks

Let’s break down each team for this exciting NFC matchup.

Philadelphia Eagles Preview vs. Packers on MNF

• WR A.J. Brown returns to the lineup after missing Week 8 due to a hamstring injury.
• It’s been a disappointing season for RB Saquon Barkley, who rushed for a league-leading 2,005 yards in 2024; however, this year, his 519 yards rank only 16th.
• Philly's defense has regressed from last season. In 2024, they allowed an average of 18.1 points per game, the lowest in the league. This year, they're giving up 23.1 points per game, which ranks 15th.
• The defending champs are the only NFC East squad with a winning record. This is the first time Philly has had four consecutive seasons with a 6-2 record or better since the 1947-50 seasons.
• The Birds' ongoing success has placed head coach Nick Sirianni in some distinguished company — he became the fourth head coach in the Super Bowl era with a 6-2 record or better in four of his first five seasons with a single team.

Green Bay Packers Preview vs. Eagles on MNF

• The Packers were hit with a devastating blow as TE Tucker Kraft suffered a season-ending ACL injury during the 16-13 loss in Week 9 to the Panthers. Kraft leads the team in receiving yards (489) and receiving TDs (6).
• We’ll see if this impacts QB Jordan Love, who is having a phenomenal season as his 70.8% completion rate ranks fifth in the NFL, and his 107.9 passer rating is sixth.
• The Packers are successful in clutch situations, leading the league with a 49% third-down conversion rate
• The pass rush was slow to start the season, but they've improved recently, evidenced by their eighth-place ranking in sack percentage over the last three games (9.8%).

Here are the top Eagles vs. Packers picks for MNF tonight on the PrizePicks real-money NFL game, including WR Christian Watson and RB Saquon Barkley, in a battle between first-place teams.

Packers WR Christian Watson Projection: 20.5 Longest Reception

• Christian Watson has had a 30+ yard reception in each of his two games since returning from an ACL injury he suffered during the 2024 campaign.
• Watson’s 23.8 yards per reception ranks fourth from Weeks 8-9 (minimum 5 targets).
• The Eagles are 28th in yards allowed per completion (10.9).
• Philadelphia plays man coverage at the 11th-highest rate (25.5%).
• According to PFF, Watson has the ninth-highest yards per catch against man coverage among wide receivers (26.0).
• The PFF lineup indicates Eagles CB Quinyon Mitchell will likely cover Watson, who has given up a 20+ yard reception in three of his last five games.

Eagles WR A.J. Brown: 7.5 Receiving Targets

• A.J. Brown has more than 7 receiving targets in five of his last six games this season.
• The 28-year-old is the target leader for the Eagles’ wide receivers in four of his last six games.
• The Packers have allowed at least one opposing pass catcher to see 7 or more targets in six of eight games this season.
• In last season’s Week 1 matchup against Green Bay, the WR out of Ole Miss had 5 catches on 10 targets for 119 yards and 1 TD.
• According to the PFF lineup, Brown will likely be covered by Packers CB Keisean Nixon, who has allowed opposing pass catchers to have 9 targets twice this season.

Eagles RB Saquon Barkley Projection: 96.5 Rush+Rec Yards

• Saquon Barkley has less than 96 rush+rec yards in seven of his eight games this season.
• The Packers have allowed one opposing running back more than 100 rush+rec yards this season.
• Green Bay is one of four teams that rank in the top-ten in rushing and receiving yards allowed to running backs.
• The former Penn State RB faced another team in that category — in the 26-23 Week 3 win over the Rams, Barkley had 55 rush+rec yards.

This Monday Night Football matchup between a pair of Super Bowl contenders could determine seeding in the NFC, and offers a great opportunity to make NFL picks on PrizePicks and win real money. Just pick your players, predict More or Less on their weekly stat projections, and cash in if your picks are correct.

Check out the Playbook throughout the remainder of the NFL season for more analysis for your PrizePicks and NFL DFS Lineups.