Tonight at the Purcell Pavilion in South Bend, the No. 1 Duke Blue Devils (25-2) face the Notre Dame Fighting Irish (12-15) in an ACC matchup that tips off at 7 p.m. ET.
The Blue Devils are on a hot streak coming into this game having won four straight, including a victory over the former No. 1 Michigan Wolverines.
It's been a brutal season for the Fighting Irish, who have lost 11 of their last 13, and their 3-11 ACC record is the third-worst in the conference.
Let’s look at a Duke vs. Notre Dame prediction and Tuesday college basketball picks. Make your picks on PrizePicks and PrizePicks Team Picks and earn real money if you’re right, including on game winners, spreads, and totals.
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Duke vs. Notre Dame Prediction
Duke brings a balanced attack to Indiana, ranking among the top-ten in both offensive and defensive ratings, as per KenPom. Offensively, they shoot with precision, ranking 14th in the nation with a 57.5% effective field goal percentage.
Notre Dame struggles to measure up on both ends of the court, ranking outside the top ten in the ACC in both points scored and allowed. You could attribute this regression to the loss of G Markus Burton in December due to an injury. They had a great start to the season with Burton in the lineup with a 7-3 record, but are just 5-12 since.
Duke vs. Notre Dame Spread, Over/Under
The Blue Devils enter this matchup as an overwhelming 17.5-point favorite, returning a 1.01x payout on PrizePicks Team Picks if they win outright.
The Fighting Irish are home underdogs with a 16.66x payout if they win, via PrizePicks Team Picks.
- Spread: Duke Blue Devils -17.5
- Over/Under: 139.5
- Game Winner Payout: Duke 1.01x | Notre Dame 16.66x
Team Picks data is live at the time of writing and is subject to change.
Duke vs. Notre Dame Prediction on Spread
Here are some facts and figures to get you set for Duke vs. Notre Dame tonight, including insights on our Duke vs. Notre Dame prediction.
- The Fighting Irish are 0-4 against teams ranked inside the top-25.
- The Blue Devils are 16-0 against unranked opponents.
- Duke has won back-to-back games against the spread.
- Notre Dame is potentially a great underdog to back, covering the spread in three of their last four when getting points.
- The Fighting Irish are confident picks against ranked opponents, covering in three of four games against them.
- Duke is 7-7 ATS against ACC opponents.
Duke vs. Notre Dame Picks for PrizePicks Today: 2/24/26
Here are two top Duke vs. Notre Dame PrizePicks picks to target on Tuesday, featuring projections for Duke F Cameron Boozer and G Isaiah Evans.
Duke F Cameron Boozer Projection vs. Notre Dame: 29.5 Points+Rebounds
- Boozer ranks fifth in the nation in points per game (22.6) and 13th in rebounds (10.0), leading the team in both categories.
- The freshman has recorded a double-double in 15 of 27 games this season, including four of his last five.
- The potential top-ten pick in the NBA Draft is one of the best shooters in the conference, ranking fourth with a 58.9% field-goal percentage.
- Notre Dame struggles on defense, ranking 11th in the conference for opponents’ field goal percentage (43.5%).
- Per EvanMiya, the son of former NBA journeyman Carlos Boozer ranks No. 1 in Bayesian Performance Rating (14.0).
Duke G Isaiah Evans Projection vs. Notre Dame: 14.5 Points
- Evans has more than 14 points in three of his last four games
- The sophomore is one of the ACC's top 3-point shooters, ranking sixth with 39 made against conference opponents.
- Notre Dame ranks 221st in the nation in 3-pointers allowed per game (8.0).
- The Fighting Irish struggle to prevent opponents from jacking up treys, as 47% of their opponents’ shot attempts come from behind the arc, according to CBB shot charts.
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Make Duke vs. Notre Dame CBB Picks on PrizePicks
Duke vs. Notre Dame picks aren’t the only avenue for hoops fans to get in on today’s college basketball action.
You can make your picks on PrizePicks and PrizePicks Team Picks and earn real money. Just pick players, predict More or Less on their projected stats, and cash in if you’re correct. With Team Picks, make predictions on winners, spreads, and over/unders, now available in 34 states.
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