DJ Moore Injury Update: Is Bills WR Playing in Week 6?

Buffalo Bills WR DJ Moore has dealt with a shoulder injury that sidelined him against the Los Angeles Rams in Week 5. As a result, Moore’s status is up in the air for Sunday’s Week 6 contest.

The Bills stay on the road to take on the Las Vegas Raiders at 4:25 p.m. ET on CBS on Sunday, October 18. What’s Moore’s outlook for suiting up in Week 6?

Below, we’ll analyze the latest DJ Moore injury update, his latest practice status, and how his injury impacts fantasy football and Bills vs. Raiders picks for PrizePicks.

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DJ Moore Injury Update: Will Moore Play This Week vs. Raiders?

Moore sat out practice Wednesday and Thursday with a shoulder injury, making his status uncertain for Sunday’s game. This comes after Moore missed the team’s Week 5 contest against the Rams after holding a questionable status.

Moore has dealt with multiple shoulder injuries early in the season. He left the team’s Week 2 contest against the Detroit Lions after landing on his shoulder in the end zone. 

Friday’s practice could go a long way towards determining Moore’s status for Week 6. 

If Moore misses Sunday’s Week 6 game, how does that affect fantasy football and Bills picks for PrizePicks?

Bills Fantasy Football Outlook If DJ Moore Is Out

The Bills brought Moore in during the offseason in a trade with the Chicago Bears to give QB Josh Allen a No. 1 wideout. The former Maryland standout offers big-play ability, but his shoulder injuries have slowed him thus far.

Entering the regular season, fantasy football managers were intrigued by Moore's potential. According to FantasyPros, Moore had a WR22 in average draft position (ADP) and was selected in the fourth or fifth round of most PPR drafts.

In four games, Moore has hauled in 12 passes for 178 yards and a TD. As he’s dealt with injuries, Moore has garnered just 20 targets this season, ranking 58th among NFL WRs. His most productive performance came in Week 1 when Moore caught 5 passes for 100 yards and a TD against the Houston Texans.

Despite missing time, Moore has recorded a 28.6% target rate, which ranks ninth among all WRs, per PlayerProfiler. Moore has also tallied an average depth of target of 15.2 yards (15th among WRs).

If Moore is sidelined in Week 6, the Bills could turn to WR Khalil Shakir through the air. Shakir leads the Bills in receptions (18) and ranks second in receiving yards (256) this season. He also has a 25.8% target rate (26th), which jumps to 27.8% (13th) in the red zone.

Week 6 offers a tantalizing matchup against a Raiders defense that has struggled defending the pass. Las Vegas surrenders 25.8 PPG (23rd) and a 44.6% success rate (21st), per RBSDM. Meanwhile, Buffalo leads the NFL in EPA per play (0.215) and ranks second in dropback EPA (0.342). 

The Raiders have surrendered a 48.8% dropback success rate (26th) and 236.4 passing yards per game (24th). If Moore can suit up, his big-play potential could be a major factor, as he averages 14.8 yards per reception in 2026. 

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Make Bills vs. Raiders Picks on PrizePicks

DJ Moore has been dealing with a shoulder injury that kept him out of the Bills’ Week 5 game against the Rams. If Moore returns to the gridiron in Week 6, he has a great matchup against the Raiders. If not, Khalil Shakir becomes a potential target.

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