Two teams on the outside looking in for a position in the NFC playoffs meet tonight in the Motor City. The Detroit Lions (7-5) host the Dallas Cowboys (6-5-1) in a critical game, with the loser staring at a long road to reach the postseason.
The Lions fell short on Thanksgiving against the rival Green Bay Packers, 31-24. Detroit has alternated wins and losses in the past eight games, averaging 38.5 points per game coming off a defeat in 2025.
The Cowboys have resuscitated their season following a 3-6-1 start, winning three straight. Dallas just logged consecutive victories over the two Super Bowl squads from last season, capped off by a 31-28 triumph over Kansas City on Thanksgiving.
Let’s look at some PrizePicks Cowboys vs. Lions TNF picks for tonight's game at Ford Field, kicking off at 8:15 p.m. ET on Prime Video.
Cowboys vs. Lions TNF Picks Tonight: Week 14
Detroit is reeling after its second home loss in six tries, while Dallas owns a 2-4 road record. The Lions enter this matchup as 3.5-point favorites, returning a 1.58x payout on PrizePicks Team Picks if they win outright.
The Cowboys are road underdogs with a 2.22x payout if they win, via PrizePicks Team Picks.
- Spread: Detroit Lions -3.5
- Total: 54.5
- Game Winner Payout: Lions 1.58x | Cowboys 2.22x
Cowboys vs. Lions Thursday Night Football Picks & NFL DFS
Here are three top Cowboys vs. Lions TNF picks to target. Key PrizePicks player projections are headlined by Dallas QB Dak Prescott, Detroit WR Jameson Williams, and Cowboys WR CeeDee Lamb.
Cowboys QB Dak Prescott vs. Lions Projection: 276.5 Pass Yards
- Prescott sits second in the NFL with 3,261 passing yards, marking his seventh season of at least 3,000 such yards.
- The former Mississippi State star is coming off consecutive 300+ yard outputs against the Eagles and Chiefs. All four of his 300+ yard outings have come at home, however.
- In six road games, Prescott is averaging 232.1 yards per contest. He has not eclipsed this passing projection in any of his six contests away from AT&T Stadium.
- The Lions have allowed more than 234 passing yards just once at home. Giants QB Jameis Winston threw for the most yards of any opposing player at Ford Field with 366 in Week 12.
Lions WR Jameson Williams vs. Cowboys Projection: 83.5 Receiving Yards
- Williams may be asked to step up with Lions leading WR Amon-Ra St. Brown nursing an ankle injury.
- The former Alabama standout just posted his best stat line of the season, piling up 144 yards on 7 receptions in the loss to Green Bay.
- In three of the last four games, the fourth-year pro has topped the 88-yard mark.
- In last season’s 47-9 rout of the Cowboys, Williams racked up 76 yards on 5 catches.
- Dallas has yielded at least 89 yards to five different WRs in the past five games.
Cowboys WR CeeDee Lamb vs. Lions Projection: 83.5 Receiving Yards
- Lamb is averaging 82.6 yards per game, which includes the Week 3 loss at Chicago that he left injured with no catches.
- The former Oklahoma star is coming off his fourth game of at least 100 receiving yards. He torched the Chiefs for 112 yards on 7 receptions, including a season-long 51-yard catch.
- Lamb has eclipsed this receiving projection on the road once: the season-opening loss at Philadelphia (110 yards).
- Last season against Detroit, Lamb hauled in 7 receptions for 89 receiving yards. His 14 targets that day were more than any number he has seen this year.
Make Picks on NFL on PrizePicks
The winner of tonight’s Cowboys/Lions game helps their cause for a playoff berth, but the loser is not in good shape coming down the stretch. There’s never been a better time to add to the excitement of every NFL moment than with PrizePicks.
There's a wide variety of player stat projections on the NFL board to make Cowboys vs. Lions TNF picks or predictions for any other game. Just pick at least two players, predict More or Less on their stats, and win if you're right.
Check out the Playbook throughout the remainder of the NFL season for more analysis.
