Heading into Week 4, there are just six teams who remain undefeated, one of whom is the Indianapolis Colts, who look to start the season 4-0 for the first time since 2009/
Indy QB Daniel Jones — one of 2025's nicest NFL surprises — and his Colts take on the Los Angeles Rams at SoFi Stadium. The game kicks off 4:25 p.m. ET, and can be seen on FOX.
The AFC clash features a ton of heavy statistical hitters who could potentially put up some big numbers, among them the NFL’s leading rusher (Colts RB Jonathan Taylor) and top receiver,(Rams WR Puka Nacua).
Below, we’ll give you our Colts vs. Rams prediction and picks for Week 4. Make your Week 4 predictions with PrizePicks NFL DFS for a chance to win real money if your picks hit!
🏈 PLAY $5, GET $50 Instantly in Lineups for your NFL Week 4 Picks → Use PrizePicks Promo Code PLAYBOOK
Colts vs. Rams Prediction, Preview for Week 4
oThe Colts come into this Week 4 matchup 3-0, which hasn’t been done in 16 years. Meanwhile, the Rams (2-1) look to rebound after being on the wrong end of the play of the week in Week 3, in a heartbreaking 33-26 loss to the Philadelphia Eagles.
Indianapolis Colts Preview
Jones and Taylor have been one of the league's best QB-RB tandems — 418.7 total yards per game, second in the NFL — through three weeks.
During the preseason, the Colts were the third-least likely team to win the AFC South, and now they sit at the top as ESPN's favorite to emerge as the division champion. The Colts’ offense has been the main factor in their surprising start to the season, leading the league in point differential (+15.7) and second in points per game (34.3).
This road tilt against a stingy Rams D that ranks fifth in the league, allowing 268.3 total yards per game will let us know if the Colts are the real deal.
Los Angeles Rams Preview
The Rams’ aforementioned loss to the Eagles was a rough one. They were leading the defending Super Bowl champions 19-7 at halftime, only to be completely shut down in the second half, scoring just 7 points and having their game-winning field goal blocked.
The Rams have been operating at a high level, especially QB Matthew Stafford and his star WRs Puka Nacua and Davante Adams. This offense remains one of the best in the league (24.3 ppg) and will test a Colts defense that's stymied offenses through three weeks (18.7 ppg allowed).
Colts RB Jonathan Taylor Projection: 87.5 Rush Yards
- Taylor averages 112.7 rushing yards per game through three weeks, leading the league with 338 rushing yards on 60 carries (5.6 ypc) and 3 TDs.
- The Rams allow 103 rushing yards per game which ranks 13th in the league.
- The former Wisconsin Badger has been making defenders miss at an impressive rate, forcing 16 missed tackles, ranking him second in the NFL.
- The Colts bellcow RB has the most explosive runs of 10+ yards (7) in the league.
- Indianapolis has the third-highest run blocking win rate (76%) in the NFL.
- Taylor leads the NFL in yards after contact (277).
Rams RB Kyren Williams Projection: 70.5 Rush Yards
- Williams is averaging 75.3 rushing yards per game with 4.11 yards per catch (YPC) through the first three weeks of the season.
- He's taking on a Colts defense that's allowed 94 yards per game on the ground.
- The former Notre Dame Fighting Irish is fourth in the league in yards after contact (164).
- He has the lowest tackle for loss percentage in the NFL (3.64%) — minimum 20 touches.
- Williams has five runs of 10+ yards coming into this Week 4 matchup.
Rams WR Puka Nacua Projection: 90.5 Receiving Yards
- Nacua is the NFL’s leading WR with 333 receiving yards and 111 receiving yards per game.
- In his lone career start against the Colts in 2023, Nacua had 9 receptions on 10 targets for 163 yards and 1 TD.
- He has been efficient through three weeks into the season with 11.5 yards per reception, 117 yards after catch, and 30.91 total EPA with a 37.63% target share.
- The former BYU Cougar has a great matchup against Mehki Blackmon, who is ranked 86th at CB in PFF coverage grade
Make Colts vs. Rams Picks on PrizePicks
The Colts vs. Rams Week 4 matchup gives you plenty of opportunities to flash your fantasy football smarts. Taylor is dialed in as the NFL’s rushing leader, and Puka Nacua remains among the most reliable receivers in the game. With both offenses playing at an explosive clip, they provide you with plenty for your NFL PrizePicks projections to build the perfect Lineup to win real money.
All you have to do is make your picks on More or Less on player projections to win real money all season long on PrizePicks.
