The ACC Tournament continues on Friday, March 13, as Clemson (24-9) takes on Duke (30-2) in the semifinals. The Blue Devils will aim to continue their impressive season as 11.5-point favorites, via PrizePicks Team Picks.
Let’s take a closer look at a Clemson vs. Duke prediction on the spread for this ACC semifinal matchup at the Spectrum Center in Charlotte, tipping off at 9:30 p.m. ET on ESPN2.
Make your college basketball picks on PrizePicks and PrizePicks Team Picks in the ACC Tournament and earn real money if you’re right, including on game winners, spreads, and totals!
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Clemson vs. Duke Prediction, Spread, Over/Under
The Blue Devils have been one of the nation’s top teams throughout the season. Meanwhile, the Tigers were one of the top ACC teams during the regular season and may have already cemented their place in the NCAA Tournament.
Duke came away with a 67-54 win on February 14 in Durham, where the Blue Devils were 13.5-point favorites. In that victory, the Blue Devils held the Tigers to just a 35% shooting performance from the field.
The Blue Devils have enjoyed the upper hand in the series with a 7-3 record over the past 10 matchups. Duke won five of the last seven matchups outright, but it's just 2-5 against the spread in that span.
Clemson vs. Duke Spread, Over/Under
The Blue Devils enter this matchup as 11.5-point favorites, returning a 1.14x payout on PrizePicks Team Picks if Duke wins outright.
Clemson is an underdog with a 5.26x payout if it wins, via PrizePicks Team Picks, where you can earn money with your picks in 35 states.
- Spread: Duke Blue Devils -11.5 (2.12x payout)
- Over/Under: 134.5 (1.96x payout)
- Game Winner Payout: Clemson 5.26x | Duke 1.14x
Team Picks data is live as of writing and is subject to change.
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Clemson vs. Duke Prediction on Spread – 3/13/26
Here are some key stats to know before locking in your Clemson vs. Duke prediction against the spread for the ACC Tournament on Friday, March 13, on PrizePicks.
- Duke rallied in the second half to defeat Florida State, 80-79, in the quarterfinals of the ACC Tournament. Meanwhile, Clemson outlasted North Carolina by the same score in a game where the Tigers led the entire second half.
- The Blue Devils have a 6-8 against-the-spread record when favored by double-digit points against ACC teams this season.
- Clemson is 5-1 ATS in its last six games against Duke, winning two of those contests outright.
- The Tigers are currently riding a three-game winning streak entering Friday’s matchup, including Thursday’s win vs. the Tar Heels when they led for 78% of the contest.
- Per Bart Torvik, Clemson ranks 20th across college basketball in adjusted defensive efficiency (97.1).
- Clemson has committed the second-fewest turnovers per game (9.5) in the ACC, behind only NC State (9.2).
- Duke has shot under 32% from beyond the arc in two of its last four games. In fact, the Blue Devils converted just 10-of-34 shots (29%) from deep vs. the Seminoles on Thursday.
- According to Bart Torvik, the Blue Devils are shooting 60.9% on 2-point field goal attempts, ranking fifth in the nation. However, Duke shot just 43.0% from the field in its win against Clemson last month.
Make Clemson vs. Duke Picks on PrizePicks
The ACC Tournament is down to the final four teams, with No. 1 seed Duke facing off against No. 5 seed Clemson in one of those matchups. The winner will take on the victor of No. 2 seed Virginia and No. 3 Miami (FL) in the ACC Tournament title game on Saturday.
You can make your Clemson vs. Duke picks on PrizePicks and PrizePicks Team Picks to earn real money. Just pick players, predict More or Less on their projected stats, and cash in if you’re correct. With Team Picks, make predictions on winners, spreads, and over/unders, now available in 35 states.
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