Monday Night Football in Week 16 features the 49ers visiting the Colts, as 49ers RB Christian McCaffrey looks to push San Francisco further up the NFC playoff ladder. Kickoff is set for 8:15 p.m. ET on ESPN from Lucas Oil Stadium.
McCaffrey continues to define the 49ers’ offensive identity. As San Francisco battles for postseason positioning, the All-Pro back faces an Indianapolis team reeling, with four straight losses.
Below are the top Christian McCaffrey stats and picks vs. the Colts on Monday Night Football. There are ample PrizePicks NFL player projections to choose from for this pivotal matchup, so let’s dive in.
Christian McCaffrey Stats, Pick for Monday Night Football
Here are two key Christian McCaffrey projections for PrizePicks tonight to help make your picks.
49ers RB Christian McCaffrey vs. Colts Projection: 61.5 Rush Yards
- McCaffrey remains the workhorse of Kyle Shanahan’s offense, averaging 18.5 carries and 65.9 rushing yards per game,to go with 9 TDs. He’s cleared 61.5 yards in three of his last four outings.
- The Colts have been vulnerable on the ground, allowing 96.6 rushing yards per game in their last five contests.
- With an 84.1% snap share — the second-highest among NFL running backs — the 49ers RB1 is positioned for another high-volume workload.
- San Francisco’s run-heavy approach (28.9 rushes per game, fifth-most in the league) only strengthens his case.
49ers RB Christian McCaffrey vs. Colts Projection: 39.5 Receiving Yards
- McCaffrey leads all running backs with 820 receiving yards, averaging 58.6 per game.
- The Colts’ secondary ranks 30th in passing defense, giving up 247.6 YOG and allowing frequent checkdowns to opposing backs.
- With rookie WR Ricky Pearsall ruled out, McCaffrey could see increased targets as QB Brock Purdy’s top safety valve.
- The former Stanford Cardinal has recorded more than 40 receiving yards in 11 of his 14 games this season.
More Christian McCaffrey Projections vs. Colts for Monday Night Football
Here are some additional Drake Maye projections vs. the Ravens for Sunday Night Football, courtesy of PrizePicks, where you can pick More or Less on stats to earn real money.
- 5 Receptions
- 0.5 Rush + Rec TDs (Goblin)
- 104.5 Rush + Rec Yds
- 20.5 Fantasy Score
- 6.5 Receiving Targets
- 18 Rush Attempts
Make 49ers vs. Colts MNF Picks on PrizePicks Tonight
49ers vs. Colts game presents plenty of MNF picks to consider — Christian McCaffrey included — in what could be a competitive affair between two teams with playoff aspirations.
You can get in on the real-money MNF action on PrizePicks. Just pick your players, predict More or Less on their projected stats, and earn rewards if you’re right.
Keep it locked in here with PrizePicks and the Playbook for continued NFL picks, predictions, and news.
