NFL Week 12 concludes with star RB Christian McCaffrey and his 7-4 San Francisco 49ers throwing down with the 6-5 Carolina Panthers at Levi's Stadium.
The Monday Night Football matchup is set to kick off at 8:15 p.m. ET on ESPN.
A three-time Pro Bowler and a former Offensive Player of the Year, McCaffrey is one of the best running backs in football. He's twice led the league in scrimmage yards, amd might well do it again, as his 1,439 scrimmage yards lead the NFL.
With the 49ers currently in the postseason as the seventh-seed, a loss tonight to ninth-seeded Carolina could cost them their playoff spot, so a big night from CMC is all but a must.
Below, we’ll give you our Christian McCaffrey stats and pick for Monday Night Football. Use PrizePicks to make picks on Week 12 player projections.
Christian McCaffrey Stats, Pick for MNF vs. Panthers
Here’s how Christian McCaffrey might look in Week 12’s Monday night matchup. Choose players, predict More or Less on their projected stats, and cash out with PrizePicks if you're right.
49ers RB Christian McCaffrey Projection vs. Panthers: 122.5 Rush+Rec Yards
Does anyone run this Route better than Christian McCaffery? pic.twitter.com/yavADgQFtP
— Coach Dan Casey (@CoachDanCasey) October 30, 2025
- This will be McCaffrey's first outing against his former team, who drafted him in 2017.
- The Stanford product is dangerous in all phases of the game, with 707 rushing yards and 732 receiving yards.
- The 29-year-old is on pace to rack up 1,000 rushing and 1,000 receiving yards. If he can pull it off, he'll become the first player in NFL history to twice accomplish the feat.
- The Panthers struggle to defend the ground game against running backs, allowing the seventh-most rushing yards to the position this year (1,091).
- Carolina has been average against pass-catching running backs, ranking 16th with 323 receiving yards allowed.
- CMC ranks eighth in the league in rushing yards before contact (412).
- The Panthers rank 30th in rushing yards allowed before contact (1.8).
- McCaffrey is a tough running back to take down as he leads all rRBs with 156 yards after contact.
Week 12’s Panthers vs. 49ers matchup presents a large variety of Monday Night Football picks to choose from — including McCaffrey — so check out the best projections and picks. Get in on the real-money MNF action with PrizePicks.
Just pick your players, predict More or Less on their projected stats, and win real money if you’re right.
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