Chiefs vs. Bills Prediction, Pick for Week 9: Patrick Mahomes, Josh Allen, More

The Chiefs and Bills, two of the top NFL teams this past decade, renew their rivalry in Buffalo for an eagerly-awaited Week 9 matchup. This game marks the 10th meeting since 2020, with the Bills winning four of five regular season games and Chiefs sweeping the four postseason rumbles. The matchup, which features two of the best NFL QBs in Patrick Mahomes and Josh Allen, kicks off at 4:25 p.m. ET on CBS.

Below, we'll break down our Chiefs vs. Bills prediction and Sunday picks for Week 9, including the top player picks on PrizePicks real money NFL game, including Chiefs QB Patrick Mahomes and Bills QB Josh Allen and RB James Cook.

Chiefs vs. Bills Prediction, Week 9 Picks

Here's how these bitter rivals are looking as we head into Sunday's grudge match.

Kansas City Chiefs Preview

• During the 2023 and 2024 season, the Chiefs won an NFL-record 17 consecutive one-score games. This season, the Chiefs are 0-3 in one-score games.
• After averaging 315.6 yards per game the first three games of the season, K.C. has averaged 415.8 yards of offense in the last five games, with WR Xavier Worthy’s return to the lineup in Week 4 and WR Rasheed Rice’s return in Week 7.
• The Chiefs are sixth in the league in scoring, averaging 26.8 points per game, and second in scoring defense, holding opponents to 16.4 points per game.

Buffalo Bills Preview

• The Bills are 4-1 in the regular season against the Chiefs since 2020, winning each of the last four regular season meetings. 
• Buffalo’s issue has been on defense, where they are allowing 150.3 rush yards per game, 31st in the NFL, ahead of only Cincinnati. 
• The Bills' offense is second in the NFL in yards per play at 6.1 and second in yards per rush at 5.2. 
• The upstate New Yorkers' wins have come against teams with a combined 10-29 record.

Chiefs vs. Bills Picks for NFL DFS & PrizePicks

Here are three Chiefs vs. Bills player picks for Week 9 for PrizePicks real money NFL game, including Chiefs QB Patrick Mahomes and Bills QB Josh Allen and RB James Cook.

‍Pick More or Less on these projections on PrizePicks — plus thousands more —to win real money this NFL season.

Chiefs QB Patrick Mahomes Projection vs. Bills: 269.5 passing yards

• After throwing for 1 passing TD in each of the first three games, Chiefs QB Patrick Mahomes has multiple TD passes in four of his last five games, totalling 14 passing TDs over this span. 
• Mahomes has 17 TD passes on the season, tied with Matthew Stafford for most in the NFL. 
• The future Hall of Famer has passed for 250+ yards in five straight games after averaging 223 passing yards in the first three games. 
• The last time Mahomes had 250+ in five straight games was in 2022, when he did it in seven straight.  

Bills QB Josh Allen Projection vs. Chiefs: 232.5 passing yards

• While the Bills are still winning, QB Josh Allen has not put up the same MVP numbers as in 2024. He has passed for 220+ yards in only two of seven games this season after doing so in nine of 17 games last season. 
• Allen had been doing it on the ground, however, with six straight games of 25+ rushing yards until being held to 7 rushing yards in Week 8.
• The reigning MVP's passer rating of 103.6 ranks ninth in the league. Last season, Allen’s 101.4 finished eighth. 

Bills RB James Cook Projection vs. Chiefs: 73.5 rush yards

• Bills RB James Cook has 753 rushing yards on the season, second to Jonathan Taylor of the Colts. 
• His 6.0 yards per rush leads the NFL. His 7 rushing TDs is tied for fourth, behind Taylor, Green Bay's Josh Jacobs, and Dallas' Javonte Williams. 
• Cook has hit 100+ rushing in four of eight games this season, also tied with Taylor for most 100+ games this season. 

Make Week 9 Football Picks on PrizePicks

Can the Chiefs earn another big win vs. Buffalo to grab a massive tie-breaker over the Bills? Or will the Bills continue their regular season dominance of the Chiefs? The Chiefs and Bills meet in a Sunday afternoon Week 9 matchup at 4:25 p.m. ET on CBS.

As the NFL season enters its ninth week, there's no better place to get real money action with your NFL predictions than on PrizePicks.

There is a wide variety of player stat projections on the NFL board, so you can make predictions on whatever you'd like — from yards to field goals. Just pick at least two players and pick More or Less on their stats to build your Lineup on PrizePicks.

Check out the Playbook throughout the NFL season for more NFL predictions for your PrizePicks and NFL DFS Lineups.