The Chargers and Jaguars' clash in Week 11 is shaping up as a pivotal matchup in the AFC. The Jaguars are 5-4, coming off a brutal collapse by surrendering a 19-point fourth-quarter lead. They now face a Chargers team that has pushed its record to 7-3 and enters the weekend on a three-game wining streak.
Kickoff is scheduled for Sunday at 1:00 p.m. ET at EverBank Stadium in Jacksonville. The Jaguars aim to regain consistency and show they can close games, whereas the Chargers look to continue their surge as one of the conference’s hottest teams.
This game carries real weight in the AFC playoff picture, and the outcome could hinge on which side executes better in all three phases.
Let's break down a Chargers vs. Jaguars prediction and some possible picks for NFL Week 11. With PrizePicks, you can make picks on player projections for this weekend and the rest of the NFL campaign.
Chargers vs. Jaguars Preview, Week 11 Prediction
Let’s preview each team playing in this AFC matchup and see how they stack up against one another. Use PrizePicks to make player picks for Week 11 and beyond.
Los Angeles Chargers Preview vs. Jaguars
The Chargers are on a solid streak after losing three of their previous four, so things are good out west. Despite issues on the offensive line due to injuries to both starting tackles, QB Justin Herbert keeps plugging along.
On the defensive side, DC Jesse Minter continues to innovate and make this unit look spectacular. The Bolts have been one of the best teams against the pass this season, and they also don’t allow much on the ground either, ranking as a top-five unit through the air and a top-14 unit defending the run.
Jacksonville Jaguars Preview vs. Chargers
The Jaguars come into this game looking to do whatever is possible to erase the memory of last week’s terrible loss to the Houston Texans. The Jaguars were up 29-10, ultimately falling 36-29 after giving up 26 points in the fourth quarter.
Injuries have decimated the Jaguars’ offense. They lost WR Travis Hunter for the season and WR Brian Thomas Jr. to an ankle sprain that he is working his way back from. TE Brenton Strange is out for Week 11 but recently had his 21-day practice window opened.
Thomas practiced in limited fashion this week, making him questionable to play in this crucial matchup against the Chargers.
Chargers vs. Jaguars Same-Game Picks for PrizePicks
Below are two Chargers vs. Jaguars same-game player picks for Week 11, spotlighting key projections to watch for Ladd McConkey and Trevor Lawrence.
You can choose More or Less on these projections on PrizePicks — along with plenty of others — for a chance to win real money this NFL season.
WR Ladd McConkey Projections vs. Jaguars: 21.5 Yards on Longest Reception
- Despite the early-season issues, McConkey has quickly become the Chargers’ top WR once again. This comes at a great time as well, since WR Quentin Johnston has cooled down after a torrid start to the season and Herbert needed his most reliable target to step up.
- The Jaguars have struggled to defend against deep shots this season, allowing the third-most completions of 20+ air yards to pass-catchers, per FTN.
- McConkey has had more than this weekend’s projection in three of his last five games.
QB Trevor Lawrence Projections vs. Chargers: 212.5 Pass Yards
- It’s no shock to most that Lawrence has not been great in 2025. Despite new head coach Liam Coen arriving from turning around QB Baker Mayfield’s career in Tampa Bay, Lawrence has not taken the jump forward most expected him to.
- Losing Hunter for the year and Thomas to multiple injuries along the way has not helped, but Lawrence has struggled plenty. This is not a great matchup for the veteran QB, either.
- The Chargers have only allowed three QBs to have more than 205 passing yards. While Lawrence has only had less than Week 11’s projection in three of nine games, he’s relied on volume most of the time, throwing the ball 40+ times in four contests.
- Without Hunter and Strange in the lineup and Thomas not at 100%, tread carefully around Lawrence’s passing projections.
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