The Chargers and Chiefs, two AFC West rivals, meet up in Kansas City for a bout that will have an impact on the division and conference playoff race.
Both teams are behind the Broncos in the AFC West, with the Chiefs eliminated from divisional contention but still alive for a Wild Card berth. The Chargers and Chiefs' Week 15 game kicks off at 1:00 p.m. ET on CBS.
Below, we'll break down our Chargers-Chiefs prediction and NFL Week 15 picks, including the top player picks on PrizePicks' real-money NFL game for Chargers QB Justin Herbert and Chiefs QB Patrick Mahomes and WR Rashee Rice.
Chargers vs. Chiefs Prediction, Spread, Over/Under
The Chargers and Chiefs clash in the second of their annual divisional matchups. In their Week 1 outing, the Chargers prevailed 27-21, ending a seven-game losing streak to the Chiefs.
Chargers vs. Chiefs Over/Under, Spread
The Chiefs enter the Sunday Week 15 game as 6.5-point favorites, returning a 1.36x payout on PrizePicks Team Picks if they win.
The Chargers are visiting underdogs with a 3.03x payout if they win, via PrizePicks Team Picks.
- Spread: Kansas City Chiefs -6.5
- Total: 41.5
- Game Winner Payout: Chargers 3.03x | Chiefs 1.36x
Team Picks data is live at the time of writing and is subject to change.
Chargers vs. Chiefs Prediction on Over/Under
The over/under of 41.5 is the fourth-lowest total of the Week 15 slate and the lowest of the season for any Chiefs game.
- The Chargers are 7-6 on the under this season, including three of the last four games after the previous four all went over.
- Low totals are nothing new to the Chargers, who have seen seven straight games listed at 46 points or less.
- LA is fourth in the NFL in defensive yards, allowing 282.2 per game, and ninth in scoring defense at 20.8 PPG.
- On the offensive side, the Chargers are 17th, scoring 23.0 PPG.
- Nine of the 13 Chiefs games have gone under the total, tied for the most behind the Saints. This includes seven of the last eight games.
- The 41.5 posted over/under is one point lower than last week’s 42.5 mark for Chiefs vs. Texans (they lost 20-10).
- The Chiefs average 24.2 PPG, which is 11th in the NFL, while they are seventh in total yards at 367.1 per game.
- On the defensive side, KC only allows 19.4 PPG, seventh-best in the NFL.
- According to FTN's DVOA, the Chiefs have the fourth-best offense compared to the Chargers' 21st-ranked group.
Chargers vs. Chiefs Week 15 Picks for PrizePicks
Here are three Chargers vs. Chiefs player picks for Week 15 for PrizePicks' real-money NFL game, including Chargers QB Justin Herbert and Chiefs QB Patrick Mahomes and WR Rashee Rice.
Chargers QB Justin Herbert Projection vs. Chiefs: 203.5 Pass Yards
- Chargers QB Justin Herbert has hit Less than his player projection in eight of 13 games this season, including the last four and five of the last six games.
- The listed projection of 203.5 is the lowest posted passing projection of the season for Herbert. The previous low was 219.5 last week vs. the Eagles (he passed for 139).
- Herbert has 379 total passing yards over his last three games, the lowest three-game stretch of his career.
- The Chargers' star QB has a passer rating of 92.7, which is 14th in the NFL. Last season, he had a 101.7 mark (seventh).
Chiefs QB Patrick Mahomes Projection vs. Chargers: 237.5 Pass Yards
- Chiefs QB Patrick Mahomes has hit More than his player projection in seven of 13 games this season.
- The listed player projection of 237.5 passing yards is the fifth-lowest of 2025 for Mahomes. From Weeks 5 to 13, each of his games featured a projection of 245.5 or higher. The last two games have been 236.5 and 237.5.
- Mahomes threw for a season-low 160 yards last week, ending a streak of nine consecutive games with 250+ yards.
- Per SumerSports, the two-time MVP is 16th among QBs with 100+ passes in average depth of target at 8.58 yards.
Chiefs WR Rashee Rice Projection vs. Chargers: 64.5 Receiving Yards
- Chiefs WR Rashee Rice has hit More on his passing prop in four of seven games since returning from suspension.
- Of Rice's seven outings, his listed projection was 60+ yards in six of them, all in the last six contests.
- Rice averages 8.3 yards after the catch per reception, most in the NFL.
- Since his return to action in Week 7, Rice has averaged 9.6 targets a game, fourth in the NFL behind Bengals WR Ja’Marr Chase, Falcons WR Drake London, and Rams WR Puka Nacua.
Make Chargers vs. Chiefs Predictions on PrizePicks
Will the Chiefs stay alive in the postseason race and get revenge for a Week 1 loss, or can the Chargers sweep them and keep within distance of the AFC-West leading Broncos? As the NFL season enters its 15th week, there's no better place to get real-money action with your NFL predictions than PrizePicks.
There is a wide variety of player stat projections on the NFL board, so you can make predictions on whatever you'd like — from yards to field goals. Just pick your players, predict More or Less on their stats, and earn real rewards if you're right.
Stay locked in on Playbook all the way through the Super Bowl for NFL predictions, picks, and news.
Team Picks and Culture Picks are event contracts offered by Performance Predictions II, LLC d/b/a PrizePicks Predict, a CFTC-registered FCM and NFA Member. All event contract customers must be U.S. residents and 18+. Some event contracts may not be available in every state. Event contract trading carries significant risk and is not appropriate for everyone. No guarantee against loss is offered. Past results are not necessarily indicative of future results. Void where prohibited by law. Restrictions apply. For full terms of service see prizepicks.com/predict-regulatory. Team and Culture Pick Early Payouts subject to market liquidity. The content provided is for informational and educational purposes only and does not constitute investment advice, or a recommendation to trade any commodity interest.
