The NFL returns to Brazil tonight for an AFC West showdown between the Chiefs vs. Chargers on Friday Night Football, live on YouTube.
The Chiefs are coming off a loss in one of the most lopsided Super Bowls of all time, while the Chargers will look to avenge their two one-possession losses to the Chiefs in 2024.
Below, we’ll give you three Chargers vs. Chiefs picks on top players, including Chiefs WR Xavier Worthy and Chargers RB Najee Harris. Pick More or Less on player stat projections in Friday’s NFL Brazil game to win real money on PrizePicks.
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Chiefs WR Xavier Worthy Projection: 61.5 Receiving Yards
- Chiefs WR1 Rashee Rice is suspended and will not play in Week 1, making Worthy the top WR for the Chiefs to start the season.
- Worthy wrapped up his rookie campaign in stellar fashion, going for 85 receiving yards in the conference finals, followed by a 157 receiving yard monster game in the Super Bowl, though most came in garbage time.
- Worthy posted 65 or more receiving yards in four of his last five games of the season.
- Worthy, following Week 13, saw an average snap share of 83%, excluding his Week 18 early exit.
- Last season, the most targeted WR facing the Chargers defense each game averaged just over 69 receiving yards.
Chiefs RB Isaiah Pacheco: 48.5 Rush Yards

- After his 10-week layoff last season due to injury, Isaiah Pacheco rushed for 212 yards across 8 games to close out the season.
- In those games, Pacheco averaged 26.5 rush yards a game, or 3.41 yards per carry.
- In the same time frame, Pacheco was outworked by the Chiefs’ RB2 in Kareem Hunt — who rushed 73 times for 268 yards, a 3.67 yards per carry average.
- The Chargers allowed 120.3 rush yards a game last season, coming in at 14th in the league.
Chargers RB Najee Harris: 6 Rush Attempts
- Harris has started 68 games in a row in Pittsburgh, but conflicting reports make it seem like it won't continue on Friday; head coach John Harbaugh said that rookie Omarion Hampton will start.
- Harris is the only RB to appear in 100% of his team’s games over the past four seasons.
- Across those four seasons, Harris has rushed at least 6 or more times in every game.
- Last season, Chargers RB J.K. Dobbins rushed 6+ times in every appearance — with backup Gus Edwards netting 6+ attempts in 10 of 11 appearances.
- Harris is recovering from an eye injury, but he was a full participant in this week's practices.
Make Friday NFL Picks on PrizePicks
Friday night’s NFL game in Brazil has the makings of a close divisional matchup, as the Chiefs vs. Chargers played two one-possession games in 2024. Players like Xavier Worthy and Najee Harris highlight the top picks to target for NFL DFS on PrizePicks — but there’s hundreds of more options to pick from on the NFL board.
Just pick your NFL players, choose More or Less on their stats, and win real money if your picks are right — up to 2000x!
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