Cavaliers vs. 76ers Prediction, Picks for Wednesday, January 14

Philadelphia 76ers C Joel Embiid navigates the court during a Wednesday NBA game.
AP Photo/Matt Rourke

An ESPN doubleheader occupies the Wednesday NBA slate, and leading things off is an Eastern Conference showdown between the 22-19 Cavaliers and 22-16 76ers. 

Wednesday’s bout (7:00 p.m. ET) could carry seeding implications for later this year, especially with both teams being a mere 1.5 games apart in the East standings. 

Below, we’ll break down our Cavaliers vs. 76ers prediction and picks for Wednesday night’s game. Make your picks on PrizePicks and PrizePicks Team Picks and earn real money if you’re right, including on game winners, spreads, and totals!

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Cavaliers vs. 76ers Prediction, Spread, Over/Under

Following last season’s 64-18 campaign, the Cavaliers haven’t been able to replicate that success and are just 5-5 in their last 10 outings. The 76ers, meanwhile, are already within two victories of matching their entire 24-win total from last year. 

Wednesday marks the 232nd all-time regular-season clash between the Eastern Conference titans. It’s a close series, with Philly holding a 119-112 advantage

Cavaliers vs. 76ers Over/Under, Spread

The Cavaliers enter Wednesday’s game as 1.5-point road underdogs, returning a 1.88x payout on PrizePicks Team Picks if they win outright.

The 76ers are home favorites with a 1.81x payout if they win, via PrizePicks Team Picks.

  • Spread: Philadelphia 76ers -1.5
  • Over/Under: 238.5
  • Game Winner Payout: Cavaliers 1.88x | 76ers 1.81x

Team Picks data is live at the time of writing and is subject to change.

Cavaliers vs. 76ers Prediction on Spread

Here are some stats to know to help you make your Cavaliers vs. 76ers prediction on Wednesday, January 14.

  • The Cavaliers are an even 3-3 against the spread as a road underdog this season. The 76ers, on the other hand, are just 5-7 ATS as home favorites.
  • In addition to being fourth in total points scored per game at 119.8, Cleveland’s 116.6 offensive rating is eighth in the league.
  • Defensively, the Cavs limit interior scoring, ranking seventh in paint PPG (47.3). Opponents shoot just 52.3% on 2-pointers against them, the NBA’s fourth-lowest mark.
  • The 76ers like to get out and run, sitting ninth in fastbreak PPG (15.6). On the other hand, they’re 28th in 2-point efficiency (52.3%) and assists per game (24.5). 
  • On the opposite end of the court, Philadelphia is 14th in scoring (115.2 PPG) and 11th in defensive rating (113.0) — solid, albeit unspectacular. 

Cavaliers vs. 76ers Injury Report

Let’s dive into the full Cavaliers vs. 76ers injury report for Wednesday, via NBA.com.

Cavaliers Injury Report 

  • Cavaliers SF Max Strus (foot) – OUT
  • Cavaliers PF Dean Wade (knee) – OUT

76ers Injury Report 

  • SG VJ Edgecombe (adductor) – Probable
  • C Joel Embiid (knee) – Probable
  • F Paul George (knee) – Probable
  • SF Kelly Oubre Jr. (knee) – Available

Cavaliers vs. 76ers NBA Picks for PrizePicks Today: Wednesday, January 14

Here are three top Cavaliers vs. 76ers picks to target for Wednesday, January 14 on PrizePicks. Player stat projections via PrizePicks are headlined by SG Donovan Mitchell, C Joel Embiid, and PG Tyrese Maxey.

Cavaliers SG Donovan Mitchell vs. 76ers Projection: 26.5 Points

  • Mitchell is posting career-high marks for scoring (29.5 PPG), field goal percentage (49.2), and true shooting percentage (62.6) this year.
  • Spida’s inside-the-arc efficiency is elite. He’s converting on 56.2% of his tries from 3-10 feet and 57.7% of his attempts from 10-16 feet, both personal bests.
  • According to databallr, Mitchell’s 32.5 true shot attempts per 100 put him in the 98th percentile. 
  • The 76ers rank 21st and 23rd, respectively, in first and third quarter scoring allowed. Mitchell is 12th and seventh in across those frames. 

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76ers C Joel Embiid vs. Cavaliers Projection: 34 Pts + Rebs

  • Embiid puts up 30.8 combined points and rebounds per night, but over his last 11 games, that number spikes to 36.6. 
  • In that same stretch, the former MVP winner has a 34.0% usage rate, 61.6 true shooting percentage, and 13.9% rebound rate. In his previous nine contests, those numbers were 32.8%, 51.8%, and 11.8%, respectively. 
  • The 2014 No. 3 overall pick amasses 33.6 true shot attempts per 100 (100th percentile) and boasts a 17.2% on-ball rate (97th percentile). 
  • Among players who average less than 30 minutes per game in 10+ games logged, Embiid is top-25 in nightly rebound chances (13.0, 23rd). 

76ers PG Tyrese Maxey vs. Cavaliers Projection: 38.5 Pts + Rebs + Asts

  • Maxey averages 42.1 combined points, rebounds, and assists. Even with Embiid ramping up, that number is 41.5 in Maxey’s last 10. 
  • Per NBARAPM, Maxey’s 28.5 points per 75 put him in the 95th percentile. 
  • The sixth-year man nets career-high thresholds in rebound rate (6.2%) and assist rate (29.4%). 
  • Via FantasyPros, Cleveland is 12th in per-game fantasy points yielded to the PG position at 50.53. 

Make Cavaliers vs. 76ers Picks on PrizePicks

Cavaliers vs. 76ers picks aren’t the only avenue hoops fans have to getting in on the daily NBA action.

You can make your NBA picks on PrizePicks and PrizePicks Team Picks and earn real money. Just pick players, predict More or Less on their projected stats, and cash in if you’re correct. With Team Picks, make predictions on winners, spreads, and over/unders, now available in 30 states. 

Stick around with the Playbook for continued NBA predictions, picks, and news.


Team Picks and Culture Picks are event contracts offered by Performance Predictions II, LLC d/b/a PrizePicks Predict, a CFTC-registered FCM and NFA Member. All event contract customers must be U.S. residents and 18+. Some event contracts may not be available in every state. Event contract trading carries significant risk and is not appropriate for everyone. No guarantee against loss is offered. Past results are not necessarily indicative of future results. Void where prohibited by law. Restrictions apply. For full terms of service see prizepicks.com/predict-regulatory. Team and Culture Pick Early Payouts subject to market liquidity. The content provided is for informational and educational purposes only and does not constitute investment advice, or a recommendation to trade any commodity interest.

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about the author

Jordan Foote is a seasoned sports writer with years of experience covering the NFL, NBA and MLB for multiple outlets. He is a Baker University alumnus, earning his degree in Mass Media with an emphasis in sports journalism. Foote was born and raised in Kansas City, where he still resides to this day.

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