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Cardinals vs. Cowboys Prediction, MNF Picks: Back Dak Prescott in Must-Win

Cowboys QB Dak Prescott hands the football to RB Javonte Williams in an NFL football game.
AP Photo/Tony Gutierrez

NFL Week 9 concludes with the Cardinals (2-5) heading to AT&T Stadium in Arlington to clash with the Cowboys (3-4-1) on Monday Night Football. With the matchup set to kick off at 8:15 p.m. ET on ESPN, let's drop our Cardinals vs. Cowboys prediction and MNF picks on PrizePicks tonight

After a great start to the season with two straight wins, the Cardinals are in free fall, dropping five consecutive games. Injuries have impacted Arizona's depth chart, as backup QB Jacoby Brissett gets his third straight start, replacing Kyler Murray. And head coach Jonathan Gannon announced backup RB Bam Knight will start this game in the backfield, as the Arizona RB room resembles an emergency room.

Consistency has been an issue for the Cowboys, as they have not won back-to-back games this season. Last week, Dallas suffered its most crushing L, with the Broncos putting up 44 points and whupping Dallas by 20.

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Cardinals vs. Cowboys Prediction, MNF Preview

Here's how things stack up heading into Monday Night's rumble.

Arizona Cardinals Preview vs. Cowboys on MNF

  • Injuries have played a large part in this losing streak. RB James Conner was lost after a season-ending foot injury, RB Trey Benson has missed the last four games with a knee injury, and QB Kyler Murray will miss his third game with a foot issue.
  • QB Jacoby Brissett will get his third straight start. He threw for 599 yards, 4 TDs, 1 INT in the last two games.
  • RB Bam Knight will make his first career start, and RB Emari Demercado is listed as the only other active running back on the roster.
  • The Cardinals have dominated this series in recent years by winning seven of the last eight matchups. This past Thursday (10/30) marked 20 years since the Cowboys last beat the Cardinals at home.

Dallas Cowboys Preview vs. Cardinals on MNF

  • The Cowboys are one of the top offenses in the league, ranking third in total yards (384.1) and second in points scored (30.8).
  • The offense has had to perform well, given how poorly the defense has played. This season, they rank 31st in points allowed per game (31.3). 
  • Dallas is coming off a 42-22 Week 8 defeat to the Broncos, but QB Dak Prescott does well at rebounding after a loss. The tenth-year QB is 31-14-1 in the game following a loss.
  • The Cowboys struggle away from AT&T Stadium; they're 1-4 on the road, compared to 2-0-1 at home.

Cardinals vs. Cowboys Picks for Monday Night Football

Here are the top Cardinals vs. Cowboys picks for MNF tonight on the PrizePicks real-money NFL game, including QB Dak Prescott and TE Trey McBride, as Arizona tries to end its five-game losing streak.

Cowboys QB Dak Prescott Projection: 268.5 Passing Yards

  • Dak Prescott’s 2,069 passing yards rank third in the league.
  • Prescott has thrown for over 300 yards in two of three home games, and leads the league in completions (204) and is sixth in completion percentage (70.1%).
  • Arizona is 27th in completions allowed per game (24.1)
  • The Cardinals are 25th in passing yards allowed per game (234.9).
  • Arizona is allowing opponents to have a 62.5% pass play percentage, the sixth-highest this season.

Cowboys RB Javonte Williams Projection: 65.5 Rushing Yards 

  • Williams topped 100 rushing yards in two of his last four outings.
  • The Cardinals have allowed 107.3 rushing yards per game over their last three contest, which ranks 16th.
  • The former Bronco has the sixth-most rushing attempts this season (124).
  • The Cardinals are 14th in the league in rush attempts allowed per game over their last three matchups (24.7).
  • The Cowboys' 67.6 PFF run blocking grade ranks ninth.
  • Arizona is 27th in PFF run blocking grade (57.1).

Cardinals TE Trey McBride Projection: 7 receptions 

  • McBride has more than 7 receptions in back-to-back games.
  • The big tight end's 18 catches in Weeks 6 & 7 were the second-most in the league during that span.
  • The Colorado State product leads all tight ends in targets (66), route participation (98.5%), and designed targets per game (1.4).
  • The Cowboys are 23rd in catches allowed to tight ends (46).
  • Dallas is last in the league in PFF coverage grade.
  • The 'Boys rank 28th in pass attempts allowed per game at home (38.7%).

Make Cardinals vs. Cowboys Picks Tonight on PrizePicks

Facing the second-best scoring offense in the NFL, the Cardinals will try to avoid their sixth straight loss, but will have to do it without Kyler Murray for the third time this season.

This Monday Night Football matchup is a great opportunity to make NFL picks on PrizePicks and win real money. Just pick your players, predict More or Less on their weekly stat projections, and cash in if your picks are correct.

Check out the Playbook throughout the remainder of the NFL season for more analysis for your PrizePicks and NFL DFS Lineups.

Get in the game! Sign up for PrizePicks and cash in on your sports predictions. Play $5 and get $50 instantly in Lineups with promo code PLAYBOOK.

about the author

John is a graduate from Quinnipiac University with a Master’s Degree in Sports Journalism. With almost 15 years working in radio, TV and blogs, it includes stops at ESPN, NBC Sports, and Audacy. Along with being an avid sports fan, he is into fitness and cooking.

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