Buccaneers vs. Bills Prediction, Picks for NFL Week 11: Josh Allen & James Cook

Bills QB Josh Allen and RB James Cook play in an NFL game.
AP Photo/Adrian Kraus

The Bills and Buccaneers, two teams in the heat of the playoff race, meet up in Tampa on Sunday. Both are coming off key losses and will feature dynamic QBs in Josh Allen and Baker Mayfield. The Sunday game kicks off at 1 p.m. ET on CBS.

Below, we'll break down our Bills vs. Buccaneers prediction and Sunday picks for Week 11, including the top player picks on PrizePicks' real money NFL game, including Bills QB Josh Allen and RB James Cook, and Buccaneers QB Baker Mayfield.

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Buccaneers vs. Bills Prediction, Picks for NFL Week 11

The Bills and Buccaneers, both coming off of losses, meet in a key Week 11 matchup. Buffalo continues their Florida swing, having lost last week in Miami. They have not won in Tampa since 1991, dropping their last four in the Sunshine State.

The Bucs play their second straight game against the AFC East, dropping last week’s game to the Patriots.

Buffalo Bills Preview

  • The Bills defense ranks 30th in the NFL against the run, allowing 147.6 yards per game, better than only the Giants and Bengals. 
  • The pass D is on the other side of the scale: The unit sits third in the NFL, holding opponents to 170.2 yards per game. 
  • Buffalo’s offense enters the week second in the NFL at 384.4 yards per game and first in rushing at 153.3 yards, 
  • Last week vs. Miami, Buffalo’s offense was held to 376 total yards and a season-low 87 on the ground vs. Miami.

Tampa Bay Buccaneers Preview

  • The Bucs rank 11th in DVOA in total defense, just behind the Eagles and Texans. 
  • Tampa Bay’s rush defense — which was ranked fifth at the end of last season and third-best in the NFL after the season’s first month — has dropped to 11th, allowing 100.8 rush yards per game.
  • On the offensive side, the Buccaneers rank 17th in total yards gained (328.3), 25th in rushing (99.8), and 14th in passing (228.6). 
  • The Bucs have not lost consecutive games all season and have not lost back-to-back outings since losing four straight in Weeks 7-10 last season. 

Buccaneers vs. Bills Prediction, Picks for NFL Week 11

Here are three Bills vs. Buccaneers player picks for Week 11 for PrizePicks' real money NFL game, including Bills QB Josh Allen and RB James Cook, and Buccaneers QB Baker Mayfield.

Pick More or Less on these projections on PrizePicks — plus thousands more — to win real money this NFL season.

Bills QB Josh Allen Projection vs. Buccaneers: 226.5 Pass Yards

  • Bills QB Josh Allen has thrown for 2+ TDs in six of nine games this season and in 12 of his last 17 games. 
  • After reaching 260+ yards passing once from Week 2 to Week 8, Allen has averaged 289.5 pass yards per game over the last two weeks. 
  • His 15 passing TDs is tied with Indy’s Daniel Jones for 13th in the NFL.
  • The Bills gunslinger also has 7 rushing TDs, fifth-most in the NFL and tops from any QB. 

Bills RB James Cook Projection vs. Buccaneers: 76.5 Rush Yards

  • Buffalo RB James Cook has six games of 85+ rushing yards and three games (including last week) where he didn’t reach 55 yards. 
  • Cook’s five 100-yd games this season is tied with the Colts' Jonathan Taylor for most in the NFL.
  • The former Georgia Bulldog is second to Taylor (1,139) in rushing yards with 920 — and this is with playing one less game. 
  • The 26-year-old tied a season low last week vs. Miami with 13 rushes. The week before he had a season-high 27 vs. Kansas City. 

Buccaneers QB Baker Mayfield Projection vs. Bills: 225.5 Receiving Yards

  • Bucs QB Baker Mayfield threw 3 TD passes vs. the Patriots last week after totalling 1 TD pass over the previous two weeks. 
  • The former Heisman Trophy winner has now thrown 2+ TD passes in six of nine games this season and 12 of his last 15 games, dating back to last season.
  • Mayfield’s passer rating of 99.2 is ninth in the NFL. 
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Can the Buccaneers rebound after a home loss to the Patriots last week and stay on top in the NFC South? Or will the Bills rebound from their L to Miami and depart the Sunshine State with one win?

As the NFL season enters its 11th week, there's no better place to get real money action with your NFL predictions than on PrizePicks.

There are a wide variety of player stat projections on the NFL board, so you can make predictions on whatever you'd like — from yards to field goals. Just pick at least two players and pick More or Less on their stats to build your Lineup on PrizePicks.

Check out the Playbook throughout the NFL season for more NFL predictions for your PrizePicks and NFL DFS Lineups.

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about the author

David Bearman spent 18 years with ESPN in their Stats & Information Department and overseeing their betting content. From 2023-25, he served as Chief Content Officer of Pro Football Network, overseeing all content, including coverage of Super Bowls 58 and 59. He is also the Founder of Betting with Bearman, a 3x a week betting newsletter and weekly podcast on Bleav Podcast Network.

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