Another Monday night, another Monday Night Football doubleheader. Which isn't a bad thing.
The Cincinnati Bengals, minus hobbled QB Joe Burrow, look to tie the Pittsburgh Steelers for the top spot in the AFC North as they head to the Mile High City to face the snake-bitten Denver Broncos on Monday Night Football. Kickoff is 8:15 p.m. ET, and the game can be seen on ABC.
The Broncos have lost back-to-back games on walk-off FGs, while the Bengals are coming off of a 48-10 blowout loss to the Vikings.
Below, we'll break down our Bengals vs. Broncos prediction and Monday Night Football picks, among them Bengals WR Ja’Marr Chase and Broncos QB Bo Nix.
🏈 Play $5, Get $50 in Lineups for your NFL Picks. Use PrizePicks Promo Code PLAYBOOK
Bengals vs. Broncos Predictions, Monday Night Football Picks
Cincinnati Bengals Preview
The Bengals enter the Monday night matchup against the Broncos eight days after their 48-10 mauling at the hands of the Vikings and Minnesota's backup QB, Carson Wentz. The 38-point drubbing was the worst loss differential in franchise history.
The Cincy defense, which finished near the bottom of every statistical category each of the last two seasons, continues to be a problem in 2025, ranking 25th in total yards and passing yards allowed, 21st in rushing yards allowed, and 26th in scoring defense.
Despite the presence of eternal WR1 Ja'Marr Chase, the Bengals offense has been worse, entering Week 4 perched at 32nd in total yards (220.7 yards per game), 32nd in rushing offense (49.0 yards per game), and 27th in passing offense (171.2 yards per game).
Cincy QB Jake Browning, after recording a 67.8 QBR (as per ESPN) subbing for Joe Burrow in Week 2, posted a 23.7 QBR in the Minnesota debacle.
Denver Broncos Preview
After opening up the season with a win over rookie QB Cam Ward and his Tennessee Titans, the Broncos have dropped back-to-back games on walk-off FGs, one to the Colts and one to the Chargers, despite not trailing in the fourth quarter of either game.
The Broncos have struggled on offense through three outings this season — they have an offensive rating of 59.4 per PFF, 29th in the NFL and one spot behind Monday's opponent. It’s been particularly bad on the passing side, with only 173.0 yards per game, 25th in the NFL.
The defense, which led the league in EPA last season at -1.00, is currently seventh at -.073 EPA/play through three weeks. Of a bigger concern is getting off the field, as the Broncos are allowing a 50% conversion rate on third downs, third-worst in the league.
Bengals vs. Broncos Picks for NFL DFS & PrizePicks
Here are three Bengals and Broncos player picks for Monday Night Football, including Bengals RB Chase Brown and Broncos QB Bo Nix.
Pick More or Less on these projections on PrizePicks — plus dozens more —to win real money this NFL season.
Bengals RB Chase Brown Projection vs. Broncos: 50.5 Rushing Yards
- Brown has been held to 47, 43, and 3 yards rushing in the three games this season. Among starting running backs, the University of Illinois product is seeing the fewest yards before contact at -.06.
- The Bengals OL, per PFF, is ranked the worst of the 32 teams in run blocking, with a 37.8 rating.
- Slow starts are nothing new to Brown, who had 104 rush yards through three weeks last season.
- The Broncos rush defense comes in 20th in the NFL, allowing 114.7 rush yards per game through three weeks.
Broncos QB Bo Nix Projection vs. Bengals: 223.5 Passing Yards
- In his three 2025 games, Nix has passed for 176, 206, and 153 yards.
- At the end of his rookie season, Nix tossed for 250+ yards in five of his final seven games.
- Nix’s 535 passing yards through three weeks is 25th of 30 qualified QBs this season.
- While the Bengals' overall defense has been terrible, their coverage defense ranks 16th in the league, per PFF.
Bengals WR Ja’Marr Chase Projection vs. Broncos: 66.5 Receiving Yards
- After finishing last season with 75-plus receiving yards in his last eight games, Chase has reached 75-plus in one out of three games this season.
- The All-Pro received 26.8% of his team’s targets in 2024, fourth-highest in the league, and averaged 10.4 targets per game, best in the NFL.
- While his target share this year is on par with last year at 28.4%, it’s ranked tenth among WRs. He’s averaging 9 targets a game, eighth in the league.
- Broncos defense has allowed 212.7 passing yards per game, 17th in the league.
Make Monday Football Picks on PrizePicks
Which AFC team will rebound from Week 3 losses with a big Monday night win? The Bengals were blown out of Minnesota last week, while the Broncos are two plays away from 3-0.
With a Monday night two-fer on tap, there's no better time or place to get real money action with your NFL predictions than on PrizePicks.
There are a wide variety of player projections on the NFL board, so you can make predictions on any number of stats, from yards to field goals. Just pick at least two players and choose More or Less on their stats to build your Lineup on PrizePicks.
Check out the Playbook throughout the NFL season for more NFL predictions for your PrizePicks and NFL DFS Lineups.
