Enjoy David Bearman's best NFL Week 10 picks, a look at four of Sunday and Monday's most compelling games, plus a breakdown of the top picks on PrizePicks NFL Week 10 picks.
- New England Patriots at Tampa Bay Buccaneers – Sunday, 1 p.m. ET
- Los Angeles Rams at San Francisco 49ers - Sunday, 4:25 ET
- Pittsburgh Steelers at Los Angeles Chargers – Sunday, 8:20 p.m. ET
- Philadelphia Eagles at Green Bay Packers - Monday, 8:15 p.m. ET
Bearman's Best NFL Week 10 Picks
NFL expert David Bearman looks at four of the most intriguing Week 10 clashes.
New England Patriots at Tampa Bay Buccaneers Picks & Stats to Know
- After finishing 2024 season 31st in total offense (292.0) and scoring offense (17.0), the Patriots have turned it around in 2025: 12th in total offense (350.7) and sixth in scoring offense (26.3 PPG).
- New England’s defense is among the league’s best, ranked first against the run (75.4) and ninth overall (299.0).
- The Patriots’ 7-2 start is their best since starting 8-0 (9-1 after 10 games) in the 2019 season when this guy named Tom Brady was at QB.
- New England has won six straight games. The last time they won seven straight was the 2021 season.
- Patriots QB Drake Maye is firmly in the MVP conversation. He’s fifth in passing yards (2,285), tied for third with 17 passing TDs and leads the NFL with a 116.9 passer rating.
- Maye has passed for 250+ yards in two straight, four out of five games and in six of nine games this season.
- After throwing for 2+ TDs in 11 of 12 games dating back to last season, Buccaneers QB Baker Mayfield has one total passing TD over the past two games. He had 2+ passing TDs in 13 of 18 games last season, including playoffs and now in 30 of his 46 games played with the Bucs.
- Mayfield passed for 289, 379, and 256 in Weeks 4-6, but only has 190 yards per game over his last two outings.
- With Bucs WR Mike Evans missing four games and out for the season and WR Chris Godwin battling injuries and missing six of eight games, Buccaneers rookie WR Emeka Egbuka has become a key weapon for Mayfield. Egbuka has 4+ targets in all eight games this season and 4+ receptions in six games.
- RB Bucky Irving has missed the last four games with shoulder and foot injuries. He led the Buccaneers backfield with 70.2 pct of the team’s snaps through the first four games. Rachaad White has received 75.1 percent of the team’s RB snaps since.
- Even with the high volume, White has reached 45+ rushing yards in two games this season.
Patriots vs. Buccaneers Picks to Target
Patriots vs. Buccaneers projections are from the PrizePicks real money NFL game — pick players, predict More or Less on their stats, and win cash when you're right.
- Patriots QB Drake Maye - 247.5 passing yards
- Buccaneers QB Baker Mayfield - 255.5 passing yards
- Buccaneers WR Emeka Egbuka - 71.5 receiving yards
Los Angeles Rams at San Francisco 49ers Stats to Know
- The Rams defense is ranked 10th in total yards (302.9). 11th against the run (99.8) and fourth in pass yards per play (5.78).
- On the offensive side, the Rams rank seventh in total yards gained (369.9) and first in passing (258.0). The Rams, Chargers, Chiefs, and Packers are the only four teams to be in the top-10 in offensive and defensive yards.
- Rams QB Matthew Stafford has passed for 245+ yards in five of eight games this season and has 2+ passing TDs in six of eight.
- Stafford’s 21 passing TDs leads the NFL and his 113.2 passer rating is fifth.
- Rams RB Kyren Williams has 3 total rushing TD in eight games this season. Last year, he had 1+ rushing TDs in 11 of 16 games, including the first six games of the season.
- WR Puka Nacua returned last week after missing Week 7 with a foot injury. He left Week 9’s game vs. the Saints with a chest injury, but is expected to play. Nacau has 85+ receiving yards in all six games in which he saw action in the second half.
- RB Christian McCaffrey failed to top 70 rushing yards in the first six games of the season, but has 100+ yards in two of his last three.
- McCaffrey has 3+ receptions and 6+ targets in all nine games this season. In seven of the games, he has 5+ catches.
- Filling in for starter Brock Purdy, Niners QB Mac Jones threw for 275+ yards in his first four starts, with 6 passing TDs. In his last three games, has not reached 240+ passing yards.
- San Francisco entered Week 6 averaging 291.5 pass yards per game, tops in the NFL. Entering Week 10, the Niners pass offense is fifth at 255.0 yards per game. On the flip side, their rushing offense is 26th at 97.1 yards per game.
Rams vs 49ers Picks to Target
Rams vs. 49ers projections are from the PrizePicks real money NFL game — pick players, predict More or Less on their stats, and win cash when you're right.
- Rams WR Puka Nacua - 95.5 receiving yards
- Rams QB Matthew Stafford - 268.5 pass yards
- 49ers RB Christian McCaffrey - 67.5 rush yard
Pittsburgh Steelers at Los Angeles Chargers Stats to Know
- The Steelers’ offense is near the bottom of the rankings, 28th in yards (288.1), 30th rushing (87.3) and 21st in passing (200.9).
- Rodgers has thrown for 200+ yards in seven of eight games this season with 2+ passing TDs in five of the eight games.
- Steelers RB snap counts through nine weeks: Jaylen Warren 246 (52.8 pct), Kenneth Gainwell 200 (42.9 pct), Kaleb Johnson 31 (6.7 pct).
- Steelers WR DK Metcalf has had an up and down season and has TDs in five of the last seven games and also has two games with 20 or fewer yards. His 5 TDs ranks T-10th among all NFL receivers.
- The Chargers defense ranked sixth in total yards (286.8) and third against the pass (177.1).
- On the offensive side, the Chargers rank fifth in total yards gained (374.5), 10th in rushing (124.0) and sixth in passing (250.6). The Chargers, Rams, Chiefs, and Packers are the only four teams to be in the top 10 in offensive and defensive yards.
- Chargers QB Justin Herbert had passed for 250+ yards in three of his last four games and in five of nine games this season. He has 2+ passing TDs in four straight games and in six of nine this season.
- The Chargers leading rusher in three of the last five games? Justin Herbert, who has 20+ rushing yards in seven of nine games this season and 30+ in his last three.
- L.A. TE Oronde Gadsden Jr., son of former Miami Dolphins WR Oronde Gadsden, has 5+ catches in four straight games.
- WR Keenan Allen has 954 receptions in a Chargers uniform, one behind HOFer Antonio Gates for the franchise record. The last time Allen played a game without a catch was 2018.
Steelers vs. Chargers Picks to Target
Steelers vs. Chargers projections are from the PrizePicks real money NFL game — pick players, predict More or Less on their stats, and win cash when you're right.
- Steelers QB Aaron Rodgers - 226.5 passing yards
- Chargers QB Justin Herbert - 256.5 passing yards
- Chargers QB Justin Herbert - 18.5 rushing yards
Philadelphia Eagles vs. Green Bay Packers
- The Eagles offense has struggled in the early part of the season: 24th in yards, 19th in rushing, 25th in passing.
- However, the offense got going heading into the Week 9 bye, averaging 33 points and 394 yards over the previous two games, including 276 yards rushing in Week 8.
- Hurts has not recorded a rushing TD in four of his past six games after having 1+ rushing TD in five straight games dating back to last year’s Super Bowl run.
- Through the first 10 quarters of this season, Hurts had 0 TD passes. He has 15 passing TDs in his last 22 quarters, throwing 2+ TD passes in five of his last six games, including 4 TD passes in Week 8’s win over the Giants.
- Eagles RB Saquon Barkley broke through vs. his old team in Week 8, rushing for 150 yards and a score. In the first seven weeks, Barkley had rushed for 60, 88, 46, 43, 30, 58, and 44 yards. In 20 games played with the Eagles last season, Barkley had 90+ yards in 15 of them.
- Ever since WR A.J. Brown met with Barkley and Hurts, his numbers have gone up. In two games since, Brown has 10 receptions on 15 targets for 201 yards and 2 TDs. In the five games before the meeting, Brown had 19 catches for 194 yards and 1 TD. Brown missed the Week 8 contest with the Giants and is expected to suit up this week.
- The Packers defense ranks second in yards per play, holding opponents to 4.61 yards per play. They are fifth in rush yards allowed and first in pass yards per play.
- Both of Green Bay’s units are in the top ten of DVOA, with the defense ranked eighth and offense sixth.
- Packers RB Josh Jacobs is second in the NFL with 10 rushing TDs. He has 8 rushing TDs in his last five games.
- Jacobs has 1+ rushing TDs in 16 of the last 17 games, dating back to last season.
- Packers QB Jordan Love has thrown for 250+ yards in six of eight games this season, averaging 258.9 pass yards per game.
- Love’s 107.9 passer rating is sixth best in the NFL.
Eagles vs. Packers
Eagles vs. Packers projections are from the PrizePicks real money NFL game — pick players, predict More or Less on their stats, and win cash when you're right.
- Packers QB Jordan Love - 233.5 passing yards
- Packers RB Josh Jacobs - 0.5 rush + receiving TDs
- Eagles RB Saquon Barkley - 76.5 rush yards
The Buccaneers, off their bye, try to slow down the red-hot Patriots, the Rams and Niners fight for the top of the NFC West, and Aaron Rodgers and the Steelers are in L.A. to face the Chargers. Plus, the Eagles and Packers play a key NFC game on Monday Night Football.
We hope these Week 10 picks and stats to know can help you make your picks and predictions on PrizePicks real money NFL game.
Simply pick your players, predict More or Less on their Week 10 stats, and win cash when you're right. It's the simplest way to play NFL DFS, all season long.
