The Eagles (11-6) host the 49ers (12-5) in one of the most anticipated matchups of Wild Card Weekend. Sunday’s game kicks off at 4:30 p.m. ET on FOX.
Philadelphia earned the third seed in the NFC after capturing the NFC East crown for the second consecutive season. The 49ers had a chance to earn the top seed in the conference, but a Week 18 loss to the Seahawks dropped them all the way down to the sixth seed as a wild card team.
Below, we will use PrizePicks Team Picks data to make a 49ers vs. Eagles spread prediction for the NFL playoff contest and point out some key trends to consider in the Wild Card Round.
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49ers vs. Eagles Spread, Over/Under
The Eagles enter their Wild Card Weekend matchup as 6.5-point home favorites, returning a 1.38x payout on PrizePicks Team Picks if they win outright.
The 49ers are road underdogs with a 2.77x payout if they win, via PrizePicks Team Picks.
- Spread: Philadelphia Eagles -6.5
- Over/Under: 43.5
- Game Winner Payout: 49ers 2.77x | Eagles 1.38x
Team Picks data is live at the time of writing and is subject to change.
49ers vs. Eagles Spread Pick for Wild Card Round
Here are some stats to keep in mind for 49ers vs. Eagles, including a spread prediction for the Wild Card Round showdown using PrizePicks Team Picks.
- In 2025, the Eagles are 4-4 against the spread at home. Meanwhile, San Francisco has a 1-2 record ATS as a road underdog.
- The 49ers possess a 10-6-1 ATS record, which is the third-best in the league.
- San Francisco has covered the spread in four of its last seven meetings against Philadelphia.
- Per Jefe’s Handiwork, the 49ers rank first with a 54.6% late down success rate, while the Eagles rank 13th at 43.6%.
- The running game could be where this Wild Card Weekend matchup is decided. 49ers RB Christian McCaffrey averages 70.7 rushing yards per game, while the Eagles allow 124.4 rushing yards per contest (22nd).
- Eagles RB Saquon Barkley had a down year, averaging just 71.3 rushing yards per contest. The 49ers surrendered just 107.8 yards per game on the ground, good for 11th.
- The 49ers rely heavily on their passing attack to put the ball in the end zone. San Francisco is fifth with 244.4 passing yards per game; the Eagles rack up just 194.3 passing yards per contest (23rd).
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Make 49ers vs. Eagles Wild Card Picks on PrizePicks
When San Francisco and Philadelphia face off on Sunday, there will be several opportunities for football fans to capitalize on player projections and much more in this Wild Card Round matchup.
You can make 49ers vs. Eagles picks on PrizePicks and PrizePicks Team Picks and earn real money. Just pick players, predict More or Less on their projected stats, and cash in if you’re correct. With Team Picks, make predictions on winners, spreads, and over/unders, now available in 30 states.
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