The 49ers vs. Colts, both in the mix of their division and conference races, meet on Monday Night Football in an AFC-NFC battle.
Colts 44-year old QB Philip Rivers almost led the Colts to a win in his return last week, but gets another shot vs. the 49ers at home.
The 49ers vs. Colts Monday Night Football game kicks off at 8:15 p.m. ET on ESPN/ABC in Indianapolis, Ind.
Below, we'll break down our 49ers vs. Colts prediction and Monday Night Football picks for Week 16, including the top player picks on PrizePicks real money NFL game, including 49ers QB Brock Purdy, RB Christian McCaffrey, and Colts RB Jonathan Taylor.
49ers vs. Colts Prediction, Spread, Over/Under
The 49ers and Colts meet for the 48th time, with the Colts having won the last five meetings, including the last meeting, 30-18, in 2021.
Indy led the AFC South for most of the season, but now finds itself two games behind the Jaguars in the division, and a game outside the Wild Card race with three games left.
The Niners are in a tight three-team race in the NFC West with the Rams and Seahawks; a win will keep them in the hunt to win the division. They have already clinched a playoff spot.
49ers vs. Colts Over/Under, Spread
The 49ers enter the Monday Night Week 16 game as 3.5-point road favorites, returning a 1.36x payout on PrizePicks Team Picks if they win.
The Colts are big underdogs with a 2.85x payout if they win, via PrizePicks Team Picks.
Spread: San Francisco 49ers -3.5 (1.72x payout)
Total: 45.5 (1.78x payout on Over)
Game Winner Payout: Colts 2.85x ($100 pays $285) | 49ers 1.4x ($100 pays $140)
All payouts listed are at the time of writing and are subject to change.
49ers vs. Colts Prediction on Over/Under
The total of 45.5 is tied for the 6th-highest over/under of the Week 16 slate.
- San Francisco has gone 9-5 to the over in its 14 games this season, with four of the last six games going over the total.
- The nine overs this year are tied for the second most this season entering Week 16. Only Dallas has hitmore overs.
- The listed total of 45.5 would mark the sixth time in the last seven games with a total of 45 or higher.
- The Niners enter Week 16 ranked 11th in the league in scoring offense at 24.6 points per game. They are fourth in the league in passing at 246.1 yards per game.
- On the defensive side, are also 11th in scoring defense, allowing 20.9 PPG.
- Indy has gone over 7-7 to the over in its 14 games this season, with three of its last four going under.
- The Colts, with Daniel Jones at QB for the first 13 of 14 games, rank sixth in the NFL in scoring, averaging 28.0 PPG.
- They also are seventh in the NFL at 5.96 yards per play and sixth at 4.85 yards per rush.
49ers vs. Colts Picks for PrizePicks in Monday Night Football
Here are three 49ers vs. Colts player picks for Monday Night Football for PrizePicks, including 49ers QB Brock Purdy, RB Christian McCaffrey, and Colts RB Jonathan Taylor
Pick More or Less on these projections on PrizePicks — plus thousands more — to win real money this NFL season.
49ers RB Christian McCaffrey Projection vs. Colts: 63.5 Rush Yards
- 49ers RB Christian McCaffrey has failed to reach his projected rushing total in eight of 14 games this season.
- McCaffrey failed to top 75 rushing yards in the first six games of the season and in 10-of-14 games this season.
- The projected rushing total of 63.5 is the lowest of the season for McCaffrey.
- The Niners RB ranks 13th in the NFL with 922 rushing yards and sixth in the NFL with 86 receptions.
49ers QB Brock Purdy Projection vs. Colts: 245.5 Pass Yards
- 49ers QB Brock Purdy gone less than his pass yards projection in three of six games played this season.
- In the six games, Purdy has thrown for 275+ three times and 200 or fewer three times.
- After throwing 4 INTs in his first two games, Purdy has only thrown 3 INT in four games since returning from injury.
- Purdy’s 96.0 passer rating would rank 13th in the NFL if he qualified.
Colts RB Jonathan Taylor Projection vs. 49ers: 97.5 Rush Yards
- Colts RB Jonathan Taylor has hit more on his rushing yards projection in seven of 14 games this season, but has failed to reach it in three of his last four games.
- The listed player projection of 97.5 rushing yards is second-highest of the season for Taylor, only behind the 99.5 listed total in Week 8 vs. Tennessee (ran for 153).
- Taylor has five 100+ yard games this season, second-most in the NFL behind James Cook (8). However, his last 100+ yard game was Week 10.
- The Colts lead back has rushed for an NFL-high 1,443 yards on the season and also leads the league with 16 rushing TDs.
- The 49ers defense has been vulnerable vs. the run this year, ranking 22nd in expected points added per rush.
Make 49ers vs. Colts Predictions on PrizePicks
Will the Colts end a four-game losing skid and stay in the AFC playoff race? Or will the Niners keep up with the Rams and Seahawks in the NFC West? The Niners and Colts meet on Monday Night Football at 8:15 p.m. ET on ESPN/ABC.
As the NFL season wraps up Week 16, there's no better place to get real money action with your NFL predictions than on PrizePicks.
There is a wide variety of player stat projections on the NFL board, so you can make predictions on whatever you'd like — from yards to field goals. Just pick your players, predict More or Less on their stats, and cash in on your predictions if you're right.
It's the simplest way to get real-money action on NFL action.
Stay locked in on Playbook all the way through the Super Bowl for NFL predictions, picks, and news.
Team Picks and Culture Picks are event contracts offered by Performance Predictions II, LLC d/b/a PrizePicks Predict, a CFTC-registered FCM and NFA Member. All event contract customers must be U.S. residents and 18+. Some event contracts may not be available in every state. Event contract trading carries significant risk and is not appropriate for everyone. No guarantee against loss is offered. Past results are not necessarily indicative of future results. Void where prohibited by law. Restrictions apply. For full terms of service see prizepicks.com/predict-regulatory. Team and Culture Pick Early Payouts subject to market liquidity. The content provided is for informational and educational purposes only and does not constitute investment advice, or a recommendation to trade any commodity interest.
