We get four college football games on Friday night to kickoff Week 2 — a warm-up for what's to come on Saturday.
While there are no ranked teams on the slate, there are notable players to watch on Friday night for CFB DFS, including Louisville (and former USC QB) Miller Moss and Maryland freshman QB Malik Washington, who ran it up with 259 yards and 3 TDs in his debut.
Below, we'll break down the top college football picks for Friday night on PrizePicks in Week 2. Make your college football predictions on PrizePicks to win real money by picking your players and predicting More or Less on stats all season long.
🏈 Play $5, Get $50 in Lineups for 2025 CFB — win or lose! Use Promo Code PLAYBOOK
Friday CFB DFS Picks for Week 2 – 9/5/25
Here are the top Friday CFB DFS picks for Week 2 of college football on September 5. Use this analysis to build your PrizePicks CFB Lineups for Friday's games.
Louisville QB Miller Moss Projection: 249.5 Pass Yards
- Louisville QB Miller Moss threw for 223 passing yards in the Week 1 51-17 win against Eastern Kentucky University.
- Miller did not play in the second half of the win against EKU.
- Moss had more than 250 passing yards in six of nine games as the starter for USC last season.
- The high passing numbers could be due to volume: USC passed on 60.13% of their offensive plays last year. Louisville only threw on 50.75% of their plays.
- James Madison allowed 143 passing yards in the 45-10 win against FCS program Weber State.
- James Madison was 45th last season in passing yards allowed per game (196.4).
Maryland QB Malik Washington Projection: 255.5 Pass Yards
- Maryland QB Malik Washington threw for 258 yards and 3 TDs in the 39-7 win over FAU.
- According to 247Sports, Washington is a four-star recruit and the No. 5-rated quarterback in the 2025 class.
- Maryland coach Mike Locksley said he chose Washington as the starter because he is the “best opportunity to win.”
- Northern Illinois allowed 155 passing yards in the 19-17 win over FCS program Holy Cross.
- Northern Illinois allowed the fifth-fewest passing yards per game last year (169.8). However, neither Power Four teams they faced last year (North Carolina State and Notre Dame) were in the top 60 in passing yards thrown per game.
Louisville RB Isaac Brown Projection: 99.5 Rush Yards
- Louisville RB Isaac Brown showcased his explosiveness in the Week 1 win with 126 rushing yards on just 6 carries. This included 31- and 68-yard TDs.
- Brown led the team last year with 1,173 rushing yards.
- His 7.1 yards per rush last season were tied for the most among running backs with at least 160 carries.
- Brown’s 13 runs of 20 or more yards were the seventh-most in the FBS in 2024.
- James Madison allowed 16 runs for 20+ yards, which was 64th last year.
Louisville WR Chris Bell Projection: 65.5 Receiving Yards
- Louisville WR Chris Bell had 5 receptions for 63 yards in Week 1.
- Bell was second on the team last year in receptions (43), receiving yards (737), and receiving TDs (4). He was only behind WR Ja’Corey Brooks, who is now in the NFL.
- Bell’s 17.1 yards per reception last season was second in the ACC (minimum 40 receptions).
- James Madison played only one game against a Power Four team last year and allowed 10 receptions of over 20 yards. That was the most amongst teams that played two or fewer Power Four opponents.
Maryland WR Jalil Farooq Projection: 53.5 Receiving Yards
- Maryland WR Jalil Farooq had 4 receptions for 43 yards in Week 1, but he also had two drops.
- Farooq had a 24-yard reception in that game, which was the second-longest amongst Maryland pass catchers.
- Farooq played the last four seasons with Oklahoma; in 2023 he was second on the team with 45 receptions.
- Farooq was limited to two games in 2024 due to injury.
🏈 Play $5, Get $50 in Lineups for 2025 CFB — win or lose! Use Promo Code PLAYBOOK
NIU WR Degree Rogers Projection: 45.5 Receiving Yards
- Northern Illinois WR Degree Rogers led the team with 73 receiving yards in Week 1.
- That was Rogers’ Division I debut; he spent the previous three seasons with Division II program Lenoir-Rhyne.
- In 2023, he led Lenoir-Rhyne in receptions (53) and receiving yards (690).
- That same year, Rogers finished fifth in the South Atlantic Conference in receiving yards.
- Maryland faced two non-Power Four teams last year; they allowed their third-fewest total yards of the season to independent UConn (310) and the fewest to FCS Villanova (231).
- Maryland allowed two FAU receivers to rack up at least 70 yards last week, despite giving up only 7 points.
Make Week 2 CFB DFS Picks on PrizePicks
Your weekends now stacked, with college football and CFB DFS in full swing. Week 2 gets started on Friday, September 5, with some one-sided games before we get to Saturday's main slate.
The four-game slate brings us some storylines to follow, including if Northern Illinois can pull off an upset for the second consecutive season with its stout defense.
No matter what your takes are, there's no better way to cash in on your college football picks than with PrizePicks' real money CFB DFS game.
Just pick More or Less on 2-6 player stat projections and get paid when your picks are right — all the way up to 2000x.
Check out the Playbook for more CFB DFS picks and college football predictions throughout the season!
