The Portland Trail Blazers (35-36) look to add to their three-game winning streak in the Mile High City vs. a talented Denver Nuggets (43-28) squad.
According to PrizePicks Team Picks, the Nuggets are 9.5-point favorites on the spread for the third of four head-to-head matchups this season. The series is currently tied at one apiece, with Portland winning the first, 109-107, before being throttled by Denver in the second, 157-103.
Trail Blazers vs. Nuggets tips off at 5:00 p.m. ET on Sunday from Denver, CO., live on NBA TV.
Below, we’ll break down our Trail Blazers vs. Nuggets prediction and Sunday NBA picks for PrizePicks.
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Trail Blazers vs. Nuggets Prediction, Spread, Over/Under
After finishing with just 36 wins last season, the Trail Blazers have a chance to match that total with a win in Denver today. Portland is playing some quality ball of late, rattling off three straight road wins.
The Blazers are led by Most Improved Player of the Year candidate SF Deni Avdija, who has the second-shortest payout for the award (3.22x) on PrizePicks Team Picks. Avdija is leading the team in points (24.2) and assists (6.6) per game while chipping in the second-most rebounds (7.0) per game for the Blazers.
Denver remains a tough cookie to crack with a talented roster led by three-time MVP C Nikola Jokic. The Nuggets may get SF Peyton Watson back from injury today, and his return would finally put Denver at full health.
There’s no doubt that when healthy, this Denver team is among the league’s top title threats. The Nuggets to win the 2026 NBA Finals is currently returning a 10x payout (fourth-shortest) on PrizePicks Team Picks.
Trail Blazers vs. Nuggets Spread, Over/Under
The Nuggets enter Sunday’s game as 9.5-point home favorites, returning a 1.25x payout on PrizePicks Team Picks if they win outright.
The Trail Blazers are road underdogs with a 4x payout if they win, via PrizePicks Team Picks, where you can earn money with your picks in 35 states.
- Spread: Denver Nuggets -9.5 (2x payout)
- Over/Under: 237.5 (1.75x payout on over)
- Game Winner Payout: Trail Blazers 4x | Nuggets 1.25x
Team Picks payouts are live as of publishing and are subject to change.
Trail Blazers vs. Nuggets Injury Report
Let’s dive into the full Trail Blazers vs. Nuggets injury report for Sunday, March 22, via NBA.com.
Trail Blazers Injury Report
- F Jerami Grant (foot): Questionable
- G Vit Krejci (calf): Questionable
- G Shaedon Sharpe (calf): OUT
Nuggets Injury Report
- SF Peyton Watson (hamstring): Questionable
Trail Blazers vs. Nuggets Prediction on Spread – 3/22/26
Here are the key stats to know before locking in your Trail Blazers vs. Nuggets NBA prediction on the spread for Sunday, March 22, on PrizePicks.
- Denver is 39-32-0 (54.9%) against the spread (ATS), the eighth-best covering percentage in the NBA.
- When Denver was last fully healthy in October, it had the second-best net rating in the NBA (+11.5), per NBA Advanced Stats.
- In today's bout with a low 237.5 total, the team with the best offense could prevail.
- The numbers strongly favor the Nuggets, as they lead the NBA in offensive rating (120.1), effective field goal percentage (57.2%), and true shooting percentage (62.3%).
- Over the last four seasons, Denver is a perfect 8-0 straight up at home vs. Portland, capped by an average margin of +18.0 points per game.
Trail Blazers vs. Nuggets Picks for PrizePicks Today: 3/22/26
Here are two of the top Trail Blazers vs. Nuggets to consider for Sunday, March 22, on PrizePicks. Today’s NBA picks for PrizePicks are headlined by Trail Blazers SF Deni Avdija and Nuggets C Nikola Jokic.
Trail Blazers F Deni Avdija vs. Nuggets Projection: 37.5 Pts+Rebs+Asts
- As mentioned, Deni is in the midst of a breakout season, averaging 37.8 points, rebounds, and assists (PRA) per game.
- Avdija launches a career-high 6.1 3-pointers per game, and he shoots +3.9% better from deep on the road.
- The Nuggets allow opponents to shoot 38.5 3-point attempts per game, the eighth-most in the NBA.
- Over its last 10 games, Denver is giving up 29.9 assists per game (third-most).
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Nuggets C Nikola Jokic vs. Trail Blazers Projection: 50.5 Pts+Rebs+Asts
- This projection could be too low for the Joker, who averages 51.2 PRA per game.
- Portland allows opponents to pull down 43.5 rebounds (13th) and dish out 26.6 assists per game (14th).
- The Trail Blazers give up a 36.2% mark from deep, the 10th-highest shooting percentage in the league.
- Jokic is taking a career-high 4.7 attempts from deep per game.
Make Trail Blazers vs. Nuggets Picks on PrizePicks
Divisional matchups are usually fun, and with both teams playing better basketball of late, this one could keep that tradition alive. Trail Blazers vs. Nuggets picks aren’t the only way hoops fans can get in on the daily NBA action.
You can make your picks on PrizePicks and PrizePicks Team Picks and earn real money. Just pick players, predict More or Less on their projected stats, and cash in if you’re correct. With Team Picks, make predictions on winners, spreads, and over/unders, now available in 35 states.
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