The Minnesota Timberwolves vs. San Antonio Spurs game is set to tip off at 9:30 p.m. ET on Wednesday, May 6, with the Spurs entering as 10.5-point favorites on the spread, via PrizePicks Team Picks.
Despite SG Anthony Edwards coming off the bench in Game 1, the Timberwolves were able to steal the series opener on Monday. Will the Spurs be able to bounce back after a deflating start to the Western Conference semifinals?
Below, we'll break down our Timberwolves vs. Spurs prediction and picks for Wednesday's NBA game, including the spread, over/under, and key player picks for PrizePicks.
Make Timberwolves vs. Spurs picks on PrizePicks now.
{{nba_offer_banner="/style-system/ui-components-playbook"}}
Timberwolves vs. Spurs Prediction, Spread, Over/Under for Game 2 – Wednesday, May 6
Entering Game 1, the Timberwolves continue to be hindered by the injury bug. Minnesota G Ayo Dosunmu was forced to miss the series opener, while star guard Anthony Edwards came off the bench.
Minnesota was still able to come away with a hard-fought 104-102 win against San Antonio. The Timberwolves produced an extremely balanced offensive effort, with PF Julius Randle leading the way with 21 points on 8-of-20 shooting, while Edwards added 18 points on 8-of-13 shooting as a reserve.
Edwards had missed the final two games of the opening-round series against the Denver Nuggets due to a bone bruise in his left knee.
Meanwhile, while Spurs C Victor Wembanyama had just 11 points, he had a performance for the ages on the defensive end. Wemby finished with an NBA playoff record 12 blocks in Game 1.
The Spurs struggled to shoot 3-pointers, finishing at just 27.8% in Game 1. That’ll certainly be an area that San Antonio will look to improve upon in Game 2 and beyond.
Timberwolves vs. Spurs Spread, Over/Under for Game 2 – Wednesday, May 6
The Spurs enter Wednesday’s game as 10.5-point home favorites against the Timberwolves, returning a 1.23x payout if they win outright, via PrizePicks Team Picks.
Here are the full payouts for the Timberwolves vs. Spurs game on PrizePicks.
- Spread: San Antonio Spurs -10.5 (1.96x payout)
- Over/Under: 218.5 (2x payout on Over)
- Game Winner Payout: Timberwolves 3.7x | Spurs 1.23x
Play the Timberwolves vs. Spurs spread or over/under on PrizePicks Team Picks to earn real money — available in 35 states!
Team Picks data is live at the time of writing and is subject to change.
Minnesota Timberwolves vs. San Antonio Spurs Timeline
Here is the full Timberwolves vs. Spurs timeline, including the playoff series game-by-game and recent matchup history.
All-Time: Spurs, 102-49
Regular Season: Timberwolves, 2-1
Series: Timberwolves, 1-0
Timberwolves vs. Spurs Conference Semifinals Timeline, Schedule for 2026 NBA Playoffs
- Game 1: Timberwolves 104, Spurs 102
- Game 2: Wednesday, May 6, 9:30 p.m. ET in San Antonio
- Game 3: Friday, May 8, 9:30 p.m. ET in Minnesota
- Game 4: Sunday, May 10, 7:30 p.m. ET in Minnesota
- Games 5-7 if necessary
{{nba_offer_banner="/style-system/ui-components-playbook"}}
Timberwolves vs. Spurs Prediction on Spread for Conference Semifinals Game 2
Here are the key game stats and trends behind our Timberwolves vs. Spurs prediction on the spread for Wednesday, May 6.
Lock in your Timberwolves vs. Spurs prediction on PrizePicks before the line moves.
- The Timberwolves are 4-1 against the spread in their last five games vs. the Spurs.
- Minnesota has racked up the fourth-most points per contest (110.9) in the NBA playoffs, behind only the Oklahoma City Thunder (122.8), New York Knicks (120.6), and Cleveland Cavaliers (111.9).
- According to NBA Advanced Stats, the Timberwolves own the fifth-best assist/turnover ratio (1.87) among playoff teams.
- The Timberwolves have defended the perimeter extremely well this postseason, holding their opponents to 30.6% shooting on 3-pointers (second among playoff teams).
- Minnesota attacks the glass with aggression, securing the second-most rebounds per game (47.0) in the NBA playoffs.
- The Spurs own the third-best defensive rating (103.2) among playoff teams. Meanwhile, the Timberwolves have tallied a 107.9 defensive rating, which ranks eighth in the NBA postseason.
Timberwolves vs. Spurs Player Picks, Stats for PrizePicks – 5/6/26
Here are the top Timberwolves vs. Spurs picks to target in the NBA Playoffs on PrizePicks for Wednesday, May 6. Today’s NBA picks for PrizePicks include G Stephon Castle and SF Jaden McDaniels.
Get a Payout Boost every night of the NBA Playoffs on PrizePicks.
Spurs G Stephon Castle vs. Timberwolves Projection: 29.5 Pts + Rebs + Asts
- Castle has averaged a combined 29.3 points, rebounds, and assists per game in six postseason matchups.
- The Spurs guard made 4 of 8 field goal attempts in Game 1 vs. the Timberwolves.
- According to databallr, Castle has averaged 20.3 potential assists per 100 possessions, which ranks in the 92nd percentile.
- Castle has registered at least 30 combined points, rebounds, and assists in three of his six playoff games.
Add Stephon Castle to your PrizePicks Lineup now.
Timberwolves SF Jaden McDaniels vs. Spurs Projection: 14.5 Points
- McDaniels has totaled 17.6 points per contest in seven games throughout the 2026 playoffs.
- The Timberwolves forward has averaged 16.0 PPG and shot 50.0% from the field in four games vs. the Spurs this season.
- Per databallr, McDaniels is shooting 41.2% from beyond the arc this season, ranking in the 95th percentile.
- McDaniels has recorded at least 15 points in four of seven contests during the 2026 postseason.
Add Jaden McDaniels to your PrizePicks Lineup now.
{{nba_offer_banner="/style-system/ui-components-playbook"}}
NBA Playoffs Live Picks: Timberwolves vs. Spurs on PrizePicks for Game 2
Here are some in-game angles to target for your Timberwolves vs. Spurs live picks in tonight’s game.
Every live NBA Lineup on PrizePicks during the NBA Playoffs enters you to win a trip to the NBA Finals — paid by PrizePicks. Make your live NBA Playoffs picks on PrizePicks.
- The Spurs average the second-most PPG (31.6) in the first quarter this season, while the Timberwolves average 28.9 PPG in the opening quarter (19th).
- Spurs C Victor Wembanyama is much more of a perimeter threat at home. Wembanyama is connecting on 37.9% of his 3-point shots in home contests, compared to just 31.3% shooting from beyond the arc on the road.
- Minnesota finishes games strong with 29.6 PPG in the fourth quarter this season, which ranks second in the league. On the other hand, San Antonio pours in 27.7 PPG in the final frame, ranking 14th in the NBA.
- The Timberwolves run a very up-tempo offense, ranking second in pace of play (98.86) among playoff teams.
Make Timberwolves vs. Spurs NBA Playoffs Picks on PrizePicks
The Timberwolves knocked off the favored Spurs in Game 1 with an impressive effort. Will Minnesota play spoiler once again in Game 2?
Don’t wait until tip-off — make your Timberwolves vs. Spurs picks on PrizePicks now and earn real money if you’re right.
Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 35 states.
Stay locked in on Playbook for daily NBA predictions, picks, and news every day all the way through the 2026 NBA Finals.
