The slumping Minnesota Timberwolves (43-28) head to the TD Garden to take on the red-hot Boston Celtics (47-23) on Sunday, March 22, in the primetime spotlight at 8:00 p.m. ET on NBC and Peacock.
The Celtics are 10.5-point favorites on the spread for the second and final head-to-head meeting of the season, per PrizePicks Team Picks. They will look to even the season series after losing the first game in Minnesota, 115-119.
Below, we’ll break down our Timberwolves vs. Celtics prediction and Sunday NBA picks for PrizePicks.
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Timberwolves vs. Celtics Prediction, Spread, Over/Under
It’s been a solid season for the Timberwolves, but they have hit a skid, losing five of their last eight games. It’s no surprise that this slide has coincided with the absence of star SG Anthony Edwards, who has missed the team’s last four games from a knee injury.
Minnesota looks to stay afloat in a competitive Western Conference playoff race. The Wolves find themselves sitting in sixth place—the final playoff spot—with a four-game cushion over the No. 7 Phoenix Suns. That could be a big enough cushion to survive Edwards’ current absence, but winning games now would certainly be a big help.
With Pistons star PG Cade Cunningham out for the foreseeable future from a collapsed lung, the Celtics are only four games back from stealing the No. 1 seed from Detroit. An idea that would have been unthinkable only nine months ago when star SF Jayson Tatum was out from a torn Achilles.
The Celtics are healthy and dangerous. “Yes” on Boston to hoist its 19th Larry O’Brien Trophy is currently returning a 6.25x return on PrizePicks Team Picks (third-shortest).
Timberwolves vs. Celtics Spread, Over/Under
The Celtics enter Sunday’s game as 10.5-point home favorites, returning a 1.23x payout on PrizePicks Team Picks if they win outright.
The Timberwolves are road underdogs with a 4.16x payout if they win, via PrizePicks Team Picks, where you can earn money with your picks in 35 states.
- Spread: Boston Celtics -10.5 (1.96x payout)
- Over/Under: 222.5 (2x payout on over)
- Game Winner Payout: Timberwolves 4.16x | Celtics 1.23x
Team Picks payouts are live as of writing and are subject to change.
Timberwolves vs. Celtics Injury Report
Let’s dive into the full Timberwolves vs. Celtics injury report for Sunday, via NBA.com.
Timberwolves Injury Report
- SG Anthony Edwards (knee): OUT
- PF/C Naz Reid (ankle): Questionable
Celtics Injury Report
- SG Jaylen Brown (quad): Probable
- C Nikola Vucevic (finger): OUT
Timberwolves vs. Celtics Prediction on Spread – 3/22/26
Here are the key stats to know before locking in your Timberwolves vs. Celtics prediction on the spread for Sunday, March 22, on PrizePicks.
- The Celtics are 40-30-0 (57.1%) against the spread (ATS), ranking sixth for covering percentage.
- On the season, Boston is tied for the second-best net rating in the NBA (+8.0), per NBA Advanced Stats.
- The Timberwolves are struggling lately, sitting 18th in net rating over their last ten games (-0.9).
- On the road, the Wolves are 14-20-0 (41.2%) ATS, the sixth-worst covering percentage in the NBA.
- Without Edwards, it is difficult to envision points for Minnesota vs. a Celtics defense that allows just 44.1% from the field (second).
Timberwolves vs. Celtics Picks for PrizePicks Today: 3/22/26
Here are two of the top Timberwolves vs. Celtics to consider for Sunday, March 22, on PrizePicks. Today’s NBA picks for PrizePicks are headlined by Timberwolves F Julius Randle and Celtics SG Jaylen Brown.
Timberwolves F Julius Randle vs. Celtics Projection: 32.5 Pts+Rebs+Asts
- Randle is averaging 33.1 points, rebounds, and assists (PRA) per game, but on the road, that number drops to 32.2.
- This is a considerable pace-down game for Randle and the Timberwolves, who rank ninth in the NBA in pace, compared to the Celtics, who are 30th.
- In addition, Boston ranks fourth in defensive rating (111.7).
- Boston has also given up the sixth-fewest rebounds (41.6) and assists (24.8) per game.
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Celtics SG Jaylen Brown vs. Timberwolves Projection: 37.5 Pts+Rebs+Asts
- Brown continues to see his projections fall with Tatum back in the lineup. Even at 37.5, this projection could still be too low.
- JB has surpassed 37.5 PRA in six of the seven games since Tatum returned to the rotation, excluding the game vs. the Spurs, where Brown was ejected in the second quarter.
- This is an awesome pace-up game for the Celtics, who rank last in pace, facing this speedy Timberwolves team.
- The First Team All-NBA candidate went for 41-6-7 (54 PRA) in his lone outing vs. Minnesota this season.
- The Timberwolves are giving up 25.2 free-throw attempts per game to opponents, the fifth-most in the league.
- Brown is averaging a career-high 7.3 free-throw attempts per game—2.2 more than his previous career high of 5.1.
Make Timberwolves vs. Celtics Picks on PrizePicks
A short-handed Wolves squad could be in trouble vs. one of the NBA's best. Plus, a contrast in pace could impact player projections for Randle and Brown.
You can make your Timberwolves vs. Celtics picks on PrizePicks and PrizePicks Team Picks and earn real money. Just pick players, predict More or Less on their projected stats, and cash in if you’re correct. With Team Picks, make predictions on winners, spreads, and over/unders, now available in 35 states.
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