Thunder vs. Spurs Prediction, Spread, Game 3 Picks – 5/22/26

Oklahoma City Thunder vs. San Antonio Spurs Game 3 is set to tip off at 8:30 p.m. ET on Friday, May 22, with the Spurs entering as 2.5-point favorites on the PrizePicks Team Picks spread.

Following C Victor Wembanyama’s sensational Game 1, the Thunder were able to bounce back to even the Western Conference Finals at one game apiece with a victory in Game 2. As the series shifts to San Antonio, which team will gain the advantage on Friday?

Below, we'll break down our Thunder vs. Spurs prediction and picks for Friday's NBA game, including the spread, over/under, and key player picks for PrizePicks.

Make your Thunder vs. Spurs prediction on PrizePicks for tonight’s Game 3.

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Thunder vs. Spurs Prediction, Spread, Over/Under for Game 3 – Friday, May 22

The Spurs began the Western Conference Finals with a statement overtime win in Game 1, punctuated by a 41-point performance from Wembanyama. San Antonio had squandered a 10-point fourth-quarter lead but ultimately outscored Oklahoma City 21-14 in the extra sessions.

In Game 2, the Thunder were able to flip the script and even the series with a 122-113 win. Reigning NBA MVP PG Shai Gilgeous-Alexander led the way with 30 points, which was certainly needed after SF Jalen Williams reinjured his left hamstring in the first half.

According to ESPN’s Shams Charania, Williams will be evaluated on a day-to-day and game-by-game basis going forward. Williams did travel with the team to San Antonio and is currently listed as questionable, according to the NBA’s official injury report.

Prior to the Western Conference Finals, Williams had missed six consecutive playoff games due to a Grade 1 left hamstring strain.

Meanwhile, the Spurs’ backcourt has also been affected by the injury bug in the early portion of the series. PG De’Aaron Fox has missed the opening two games of the series due to an ankle injury.

In addition, G Dylan Harper is dealing with right adductor soreness after leaving Game 2 in the third quarter. Harper had moved into the starting lineup to begin this series when Fox was out.

Thunder vs. Spurs Spread, Over/Under – Friday, May 22

The Spurs enter Friday’s game as 2.5-point home favorites against the Thunder, returning a 1.72x payout if they win outright, via PrizePicks Team Picks.

Here are the full payouts for the Thunder vs. Spurs game on PrizePicks.

• Spread: San Antonio Spurs -2.5 (1.92x payout)
• Over/Under: 218.5 (1.81x payout on Over)
• Game Winner Payout: Thunder 2x | Spurs 1.72x

Make your Thunder vs. Spurs prediction on spread or over/under on PrizePicks Team Picks — available in 35 states!

Team Picks data is live at the time of writing and is subject to change.

Oklahoma City Thunder vs. San Antonio Spurs Timeline

Here is the full Thunder vs. Spurs timeline, including the playoff series game-by-game and recent matchup history.

All-Time: Spurs, 107-91

Regular Season: Spurs, 4-1

Series: Tied, 1-1

Thunder vs. Spurs Western Conference Finals Timeline, Schedule

• Game 1: Spurs 122, Thunder 115 (2OT)
• Game 2: Thunder 122, Spurs 113
• Game 3: Friday, May 22, 8:30 p.m. ET in San Antonio
• Game 4: Sunday, May 24, 8:00 p.m. ET in San Antonio
• Game 5: Tuesday, May 26, 8:39 p.m. ET in Oklahoma City
• Games 6-7 if necessary

Thunder vs. Spurs Prediction on Over/Under for NBA Western Conference Finals Game 3

Here are the key game stats and trends behind our Thunder vs. Spurs prediction on the over/under for Friday, May 22.

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• The over is 4-2 in the last six meetings between the Thunder and Spurs.
• The Thunder have had one of the better track records when it comes to the over this season. The over is 51-41 throughout the 2025-26 season for them, which is good for a 55.4% cover rate (sixth-best in the league).
• According to NBA Advanced Stats, the Thunder lead the NBA postseason in offensive rating (123.4), while the Spurs aren’t far behind in third (116.3).
• Oklahoma City owns the second-best effective field goal percentage (57.4%) this postseason, while San Antonio has the third-best (55.9%).
• The over is 7-0 in the Spurs’ last seven games, while it carries a 5-0 mark over the Thunder’s last five contests.

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Thunder vs. Spurs Picks, Player Stats for PrizePicks – 5/22/26

Here are the top Thunder vs. Spurs picks to target in the NBA Playoffs on PrizePicks for Friday, May 22. Today’s NBA picks include Shai Gilgeous-Alexander, Stephon Castle, and Victor Wembanyama.

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Thunder PG Shai Gilgeous-Alexander vs. Spurs: 38.5 Pts + Asts

• Gilgeous-Alexander has recorded at least 39 points and assists in two of his last three contests.
• The Thunder PG has thrived away from home. In road contests, Gilgeous-Alexander has posted a 69.6% true shooting percentage.
• According to databallr, Gilgeous-Alexander has tallied 18.6 potential assists per 100 possessions this season, which ranks in the 79th percentile.
• SGA has averaged 10.5 APG in the first two games of the Western Conference Finals.

Add Shai Gilgeous-Alexander to your PrizePicks Lineup now.

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Spurs C Victor Wembanyama vs. Thunder: 15.5 Rebounds

• Wembanyama has secured at least 17 rebounds in three of his last four games, including in Games 1 and 2 vs. the Thunder.
• According to NBA Advanced Stats, Wembanyama has pulled down 4.7 contested boards per game, which ranks third in the 2026 postseason.
• The Spurs’ superstar big has recorded 14 offensive rebounds in the first two games of the Western Conference Finals. Additionally, Oklahoma City allows 12.2 offensive RPG this postseason, tied for the fourth-most among playoff teams.
• Per databallr, Wembanyama has grabbed 28.7% of his defensive rebound opportunities, ranking in the 100th percentile.

Add Victor Wembanyama to your PrizePicks Lineup now.

Spurs SG Stephon Castle vs. Thunder: 32 Pts + Rebs + Asts

• Castle has registered at least 33 PRA in each of his last three games.
• The Spurs SG has averaged 20.2 PPG throughout the 2026 NBA Playoffs but has seen his scoring average increase to 22.2 PPG over his last five games. Castle is shooting 34.6% (9-of-26) from 3-point land during that span.
• According to databallr, Castle records 20.3 potential assists per 100 possessions, ranking in the 91st percentile. In addition, he has averaged 9.5 APG in the opening two games of the Western Conference Finals.
• Castle spends 33.2% of his time on the court as a ball-handler, which ranks in the 66th percentile.

Add Stephon Castle to your PrizePicks Lineup now.

NBA Playoffs Live Picks: Thunder vs. Spurs on PrizePicks for Game 3

Here are some in-game angles to target for your Thunder vs. Spurs live picks. 

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• Both the Spurs and Thunder have gotten off to sensational starts this season. San Antonio averages the second-most first-quarter PPG (31.4), while Oklahoma City puts up 30.5 points in the opening 12 minutes. 
• The Spurs operate at an extremely quick tempo, while the Thunder are more methodical. According to NBA Advanced Stats, San Antonio ranks third in pace of play (99.22) among playoff teams, while Oklahoma City is ninth (95.80).
• Gilgeous-Alexander’s scoring average is nearly identical on the road compared to at home (31.0 & 31.2). However, the Oklahoma City star is shooting 47.7% from deep in road games.
• The Thunder have taken exceptional care of the basketball during the 2026 postseason. Per NBA Advanced Stats, Oklahoma City ranks first in assist-to-turnover ratio (2.22), compared to San Antonio, who ranks ninth (1.59).

Make Thunder vs. Spurs WCF Game 3 Picks on PrizePicks

The Spurs and Thunder have put together some electric offensive performances in the opening two games of the Western Conference Finals. Could there be more of the same in store for Game 3?

Don’t wait until tip-off — make your Thunder vs. Spurs picks on PrizePicks now and earn real money if you’re right.

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