Only six games populate Wednesday’s NBA slate, but the night kicks off with a potentially thrilling matchup between the best of both conferences.
Tipping at 7:30 p.m. on ESPN, the Oklahoma City Thunder are on the road to face the Detroit Pistons at Little Caesars Arena. It’s a battle of the No. 1 seeds when the East hosts the West under the bright lights.
Below, we’ll break down our Thunder vs. Pistons prediction and picks for Wednesday night’s game. Make your NBA picks on PrizePicks and PrizePicks Team Picks and earn real money if you’re right, including on game winners, spreads, and totals!
{{nba_offer_banner="/style-system/ui-components-playbook"}}
Thunder vs. Pistons Prediction, Spread, Over/Under
Under head coach J.B. Bickerstaff, the Pistons made a massive leap from 2023-24 to 2024-25 in his debut in town. Going 44-38, they made it back to the playoffs and have now turned that success into an Eastern Conference-leading 42-14 record entering Wednesday’s play.
The Thunder, meanwhile, are coming off a campaign that saw them hoist the Larry O’Brien Trophy. As of Wednesday, their 45-14 record leads the NBA, even with the team nursing numerous injuries throughout the season.
Detroit is 8-2 in its last 10, with OKC being 7-3 in the same stretch. Wednesday is the 150th regular-season clash between the two — the Thunder own a 78-71 series lead.
Thunder vs. Pistons Spread, Over/Under
The Thunder enter Wednesday’s game as 6.5-point road underdogs, returning a 3.33x payout on PrizePicks Team Picks if they win outright.
The Pistons are home favorites with a 1.33x payout if they win, via PrizePicks Team Picks, where you can earn money with your picks in 34 states.
- Spread: Detroit Pistons -6.5
- Over/Under: 221.5
- Game Winner Payout: Thunder 3.33x | Pistons 1.33x
Team Picks data is live at the time of writing and is subject to change.
Thunder vs. Pistons Injury Report
Let’s dive into the full Thunder vs. Pistons injury report for Wednesday, February 25, via NBA.com.
Oklahoma City Thunder Injury Report
- N/A — not yet submitted
Because they’re on the second night of a back-to-back, the Thunder turn in a late injury report. On Tuesday, the trio of PG Shai Gilgeous-Alexander (abdominal), SG Ajay Mitchell (ankle), and F-G Jalen Williams (hamstring) was listed as OUT.
G Alex Caruso (ankle) and C-PF Chet Holmgren (back) were questionable, although both wound up playing against the Toronto Raptors.
Detroit Pistons Injury Report
- C Isaiah Stewart (league suspension): OUT
Thunder vs. Pistons Prediction on Spread
Here are the key stats to know before locking in your Thunder vs. Pistons prediction on spread for Wednesday, February 25 on PrizePicks.
- This is just the second time all year the Thunder have been road underdogs, owning an 0-1 against-the-spread record in such scenarios. The Pistons are 11-13 ATS as home favorites.
- No team boasts a higher average scoring margin than OKC at +11.7, and they’re third in overall shooting percentage (48.6).
- Defensively, head coach Mark Daigneault’s crew continues to thrive, surrendering the second-lowest effective field goal clip (51.7%) in the NBA.
- Detroit is one of the most punishing scoring teams in the league, sitting second in both fastbreak production (18.4 PPG) and paint output (57.1 PPG).
- Under Bickerstaff, the Pistons have a suffocating defense, holding opponents to 44.1% shooting (second) and just 37.4 made shots each night (first).
Thunder vs. Pistons Picks for PrizePicks Today: 2/25/26
Here are three top Thunder vs. Pistons picks to target for Wednesday, February 25 on PrizePicks. Player stat projections via PrizePicks are headlined by SG Cason Wallace, PG Cade Cunningham, and C Jalen Duren.
Thunder SG Cason Wallace vs. Pistons Projection: 20.5 Pts + Rebs + Asts
- On the year, Wallace averages just 14.3 points, rebounds, and assists (PRA). In the month of February, however, that’s up to 23.1.
- Despite his recent success, Wallace’s 53.6 true shooting percentage is a career-low mark.
- The third-year guard brings down just 8.4% of defensive rebounds, sitting in the 25th percentile via databallr.
- Per FantasyPros, only five teams cede fewer fantasy PPG to the SG position than the Pistons at 40.23.
{{nba_offer_banner="/style-system/ui-components-playbook"}}
Pistons PG Cade Cunningham vs. Thunder Projection: 40.5 Pts + Rebs + Asts
- In 50 games played this year, Cunningham posts 40.9 PRA on a nightly basis. That’s held true in February, even rising a bit to 41.3.
- There aren’t many better midrange scorers than Cunningham, who cans 46.6% of his looks from 3-10 feet, 47.0% from 10-16 feet, and 47.8% from 16 feet to the 3-point line.
- Oklahoma City is a middle-of-the-pack team when it comes to allowing boards to PGs, ranking 14th (6.27 per game).
- According to NBARAPM, Cunningham averages 23.9 potential assists and 13.5 actual assists per 100 possessions, both new personal bests.
Pistons C Jalen Duren vs. Thunder Projection: 27.5 Pts + Rebs
- Duren produces 28.5 points and rebounds per game. In his last eight outings, that figure is 29.8.
- The fourth-year big does most of his dirty work in short range, making 72.7% of his attempts from 0-3 feet and 56.7% from 3-10 feet.
- This is the third year in a row Duren owns a total rebounding share of at least 21%.
- Per NBA Advanced Stats, among players with 20+ games logged, Duren ranks fourth with 19.8 rebounding chances per contest.
Make Thunder vs. Pistons Picks on PrizePicks
Thunder vs. Pistons picks aren’t the only avenue hoops fans have to getting in on the daily NBA action.
You can make your picks on PrizePicks and PrizePicks Team Picks and earn real money. Just pick players, predict More or Less on their projected stats, and cash in if you’re correct. With Team Picks, make predictions on winners, spreads, and over/unders, now available in 34 states.
Stick around with the Playbook for continued NBA predictions, picks, and news.
