There are several excellent defenses in action during the NFL Divisional Round. Still, some of the biggest names in the league could have productive games, including 49ers RB Christian McCaffrey and Seahawks WR Jaxon Smith-Njigba.
Below, we'll discuss McCaffrey and Smith-Njigba, and get into more of the top NFL Picks for the Divisional Round games for PrizePicks, including some quick picks to keep in mind.
Quick PrizePicks NFL Picks for Divisional Round Games
Here are some quick PrizePicks picks for NFL Divisional Round games, including projections for pass yards, rush yards, and receiving yards.
Seahawks QB Sam Darnold vs. 49ers Projection: 236.5 Pass Yards
- Seahawks QB Sam Darnold threw for fewer than 235 yards in a game seven times during the regular season.
- In Week 1, Darnold had 150 passing yards in a 17-13 loss to the 49ers. He beat them in Week 18, totaling just 198 passing yards in a 13-3 victory.
Seahawks RB Kenneth Walker III vs. 49ers Projection: 58.5 Rush Yards
- Seahawks RB Kenneth Walker III lost work to teammate RB Zach Charbonnet down the stretch. While Charbonnet had 52 carries over the final four games, Walker was given 51 rushing attempts.
- Walker averaged 56.3 rushing yards per game at home this season, versus 64.1 yards per game on the road.
Bears RB D’Andre Swift vs. Rams Projection: 14.5 Receiving Yards
- Bears RB D’Andre Swift caught 2 passes for 38 yards in a 31-27 win over the Packers last week.
- The Rams allowed the eighth-most receptions to running backs (83) this season.
- Los Angeles led the NFL by averaging 30.5 points per game, while the Bears allowed the tenth-most points per game (24.4). If the Bears’ defense can’t slow the Rams down, their offense might need to throw a lot to try and keep pace.
NFL Divisional Round Picks for PrizePicks
Here are the top picks for the NFL Divisional Round. Player projections via the PrizePicks real money NFL game.
49ers RB Christian McCaffrey vs. Seahawks Projection: 50.5 Receiving Yards
- McCaffrey caught 6 of 8 targets for 66 yards against the Eagles last week.
- The star running back accounted for 23.5% of the 49ers’ targets this season.
- TE George Kittle missed six games during the regular season. McCaffrey recorded at least 52 receiving yards in five of them. In three, he posted at least 80 receiving yards.
- The former Panther was targeted 17 times over two regular season meetings with the Seahawks. The result was 9 catches for 73 yards in Week 1 and 6 receptions for 34 yards in Week 18.
Seahawks WR Jaxon Smith-Njigba vs. 49ers Projection: 9.5 Rec Targets
- Smith-Njigba set career highs in targets (162), receptions (119), receiving yards (1,793), and TDs (10) this season.
- The third-year receiver led the Seahawks in target share (35.7%) and team air yards (49.2%).
- Per 4for4 Football, the 49ers allowed the 12th-highest explosive pass rate (12.8%) in the league.
- After racking up 124 receiving yards on 13 targets versus the 49ers in Week 1, Smith-Njigba had 6 receptions for 84 yards on 8 targets against them in Week 18.
Broncos QB Bo Nix vs. Bills Projection: 23.5 Rush Yards
- Broncos QB Bo Nix followed up his 92 rushing attempts during his rookie campaign with 83 carries this season.
- In his two-year career, he has rushed for 786 yards.
- The 25-year-old ran for at least 42 yards in both of his final two games of the regular season.
- The Bills allowed the most yards per carry (6.69) to quarterbacks this season, then permitted Jaguars QB Trevor Lawrence to rush for 31 yards against them in the Wild Card Round.
Broncos RB RJ Harvey vs. Bills Projection: 19.5 Receiving Yards
- Following the Broncos’ Week 12 bye, RB RJ Harvey was targeted at least 4 times in five of their final six games. In four of those matchups, he finished with at least 25 receiving yards.
- The rookie running back averaged 7.8 yards after the catch this season.
- The Broncos targeted Harvey on 22.8% of his routes.
- Jaguars RB Travis Etienne Jr. caught all 5 of his targets against the Bills last week, totaling 49 receiving yards and 1 TD in the Jaguars’ 27-24 loss.
Bills WR Khalil Shakir vs. Broncos Projection: 7 Receiving Targets
- Bills WR Khalil Shakir was targeted 12 times versus the Jaguars. He caught all of them for 82 yards.
- No other player on the Bills had more than 5 targets last week.
- After being targeted 100 times in 2024, Shakir finished the 2025 campaign with 95 targets.
- Shakir was the Bills’ top wide receiver by a relatively wide margin. The player who finished second to Shakir in targets was WR Keon Coleman, who had 59 passes thrown his way.
- The Broncos had the sixth-most passes attempted against them in the league (593) this season.
Bills WR Brandin Cooks vs. Broncos Projection: 30.5 Receiving Yards
- Bills WR Brandin Cooks caught 3 of his 5 targets for 58 yards versus the Jaguars.
- Other than Shakir and Cooks, no other Bills wide receiver finished the matchup with more than 3 targets.
- The Bills lost WR Gabe Davis for the rest of the playoffs after he tore his ACL against the Jaguars. Prior to his injury, he had caught 2 of 3 targets for 14 yards.
- Coleman appears to have fallen out of favor with the Bills. Since Week 10, he has totaled 11 targets and seven receptions. He was only targeted once against the Jaguars.
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Make NFL Divisional Round Picks on PrizePicks
Two of the biggest names in the league will battle in the Divisional Round when Smith-Njigba and McCaffrey meet for the third time this season. While they will look to continue to churn out juicy stat lines, there are some lesser-hyped players who could also have a productive weekend. Two unsung heroes could end up being Cooks and Harvey.
With plenty of positions and projection categories to consider, now is the time to build your NFL Lineup on PrizePicks. Just pick More or Less for at least two NFL player stat projections to build your Lineup on PrizePicks. Check out the Playbook for more NFL picks and analysis throughout the playoffs.
