All or nothing.
That’s what our NFL Week 10 winners and losers was all about: Huge games and massive disappointments.
That would stand to reason, as we saw an edge-of-your-seat thriller across the pond (the Indy-Hotlanta 31-25 OT nail-biter in Germany), last-gasp dubs from Chicago and Houston, and one truly weird-ass upset (Miami over Buffalo…really!?!!?).
On the other side of the coin, the victors in each of the three late-slate games all topped 42 points, with the Lions and the Seahawks each winning by a score of 44-22. Which isn’t weird at all.
That all being the case, one would think that the weekend’s winners won big and the losers lost bad.
And one would be correct.
NFL Week 10 Winners & Losers
Here's who did and didn't crush NFL Week 10.
WINNER: Colts RB Jonathan Taylor
At this point, the back who would get my MVP vote is a veritable winners list plug-and-play. The league-leader in yards went full Madden in Berlin, with 3 rushing tuddies (!) 244 rushing yards (!!), and 46.6 fantasy points. (!!!), topping fantasy's overall No. 2 (Detroit’s Jahmyr Gibbs) by 11.4 points.
I don’t think a single player on my fantasy roster scored over 11.4 points. So there’s that.
This was Taylor’s third 30+ fantasy point performance in his last four games, so I’m thinking J.T. should be a start ‘em candidate in tomorrow’s start/sit column, don’t you?
LOSER: Saints RB Alvin Kamara
It kind of breaks my heart that Alvin Kamara is, in a word, washed. His 11.5 fantasy point total (RB15) in New Orleans’ surprising 17-7 win over what was a relatively hot Carolina team is considered a good performance from him here in 2025.
And this comes one season after Kamara posted a career-tops in rushing yards (950) and his highest number of rushing touchdowns (6) since the 2020 season.
But unless your name is Derrick Henry, after a certain age — in Kamara’s case, that age is 30 — running backs have been known to fall off the cliff. And considering Kamara hasn’t hit 50+ rushing yards in seven of his ten games this season, it looks like we’re here. Sigh.
WINNER: Jaguars WR Parker Washington
Show of hands, did you snatch Parker Washington off of your league’s waiver wire on Wednesday?
[My hand is raised, thank you very much.]
We lucky suckers won the waiver week, as the former Penn State standout couldn’t stay out of the end zone, catching a TD from QB Trevor Lawrence and taking a punt return to the house, giving him a total of 14.9 fantasy points (WR10).
Unfortunately for we waiver wire geniuses, Lawrence seems to have fallen off a cliff of his own, managing just 158 passing yards on 13-of-23 slings, while taking 5 sacks. And logic tells us that it’s difficult for a receiver to blow up a fantasy box score when his quarterback completes a piddly baker’s dozen.
LOSER: Jaguars QB Trevor Lawrence
See above.
WINNER: Bears QB Caleb Williams
Caleb Williams came into the league touted as the next Patrick Mahomes.
He isn't.
And since he isn’t the next Patrick Mahomes — and since he’s not yet quite as good as Pats QB Drake Maye, the man who was selected two spots behind him in the 2024 draft — the USC product been considered a bummer, if not a bust.
That narrative has been blown out of the water, as over the previous two games, the former Heisman Trophy winner has led his Bears to consecutive last-minute wins, putting them right in the playoff mix, something that few thought would be possible this quickly after last season’s 5-12 debacle.
The fact that he finished the week as QB4 (25.1 points) one week after landing at QB1 (36.7 points) doesn’t hurt his cause for top-shelf-ness.
LOSER: Steelers QB Aaron Rodgers
Caleb Williams’ stud performance made my Bears-loving heart sing with joy. Aaron Rodgers’ garbage performance made my cardiovascular system equally happy.
In the Steelers’ anemic 25-10 loss to the Chargers — and the game wasn’t even that close — senior citizen Rodgers looked every one of his 65-years, staggering his way to a 50.6 passer rating and 8.4 fantasy points (QB21), a nightmare even worse than Trevor Lawrence's.
Is it possible the eternally-smug QB is washed, Kamara-style? One can only hope.
WINNER: Rams QB Matthew Stafford
Year in and year out, hardcore fantasy players (myself included) take Matt Stafford for granted. Like this past summer, his average draft position was QB22, one spot behind, of all people, underperforming Tennessee rookie Cam Ward.
After yesterday’s magnificent 26.9 fantasy point performance (QB2), Stafford is tied for this season’s QB6, a piddly 2.5 points behind QB1, Patrick Mahomes. The fact that his Rams are 0.5 games away from owning the league’s best record is a good part of the reason that some Vegas smarty-pantses give him the third-best shot at winning the MVP.
And you drafted him behind Cam Ward.
LOSER: Panthers WR Tetairoa McMillan
We can’t yet call rookie McMillan a stiff. But we can’t not call him a stiff.
For the third time in four weeks, the University of Arizona product couldn’t top 6.0 fantasy points, catching 5 of his 8 targets for 60 yards, with nary a trip to the end zone to be seen.
Next week, Carolina faces Atlanta — the NFL’s top defense against the pass — so you probably shouldn’t depend on him to help you down the stretch of your fantasy season.
And he's on my roster. Ugh.
WINNER: Texans QB Davis Mills
One of the general maxims in sports is, “You can’t lose your starting job due to injury.”
After watching his QB2 Davis Mills dismantle a pretty good Jacksonville defense, Houston head coach DeMeco Ryans might have to rethink that one.
With incumbent starter C.J. Stroud in concussion protocol, Mills straight-up balled out, hurling for 292 yards, 3 touchdowns, and a whopping 28.7 fantasy points, landing him as Week 10’s QB1.
Stroud’s timeline for return is hazy — better safe than sorry with concussions — but it’s possible, just possible, that Mills both saved the 4-5 Texans’ season and earned himself a permanent place in the starting lineup.
LOSER: Seahawks QB Sam Darnold
Darnold wins the Weirdest Stat Line of the Week award, and it wasn’t even close.
His Seahawks obliterated the visiting Arizona Cardinals 44-22, yet Darnold threw for just 178 yards and a single TD, number so bizarre that I went to multiple website to confirm it wasn’t a typo.
It wasn't.
The even weirder part is that the ‘Hawks outgained the Cards in total yards by a mere 37 yards, while outscoring them by 22. But Seattle is now 7-2, and when it comes to his 5.9 fantasy point, QB24 finish, I doubt Darnold cares one bit.
Regardless of whether your Week 10 PrizePicks picks were good (J.T.), bad (Slingin' Sammy D.), or ugly (smug Aaron Rodgers), you had a ton of fun making your selections, and will continue to do so as the NFL season progresses.
And if you enjoyed our NFL Week 10 winners and losers, stick with Playbook all season for advice, predictions, takes, winners, and losers.
