Lakers vs. Cavaliers Prediction, Spread: Luka, Spida Superstar Tussle

The Los Angeles Lakers (28-17) and Cleveland Cavaliers (28-20) each try to keep their winning streaks alive tonight.

The Lakers continue their eight-game Grammys road trip, coming off consecutive victories at Dallas (116-110) and Chicago (129-118).

The Cavaliers seek their fifth straight win, fresh off back-to-back double-digit victories over Orlando.

Let’s look at the Lakers vs. Cavaliers prediction for Wednesday’s battle at Rocket Arena tipping off at 7:00 p.m. ET on ESPN. Make your picks on PrizePicks and PrizePicks Team Picks and earn real money if you’re right, including on game winners, spreads, and totals.

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Lakers vs. Cavaliers Prediction, Spread

Cleveland captured both matchups from Los Angeles last season, routing the Lakers at home, 134-110, followed by a 122-110 triumph on December 31, 2024. 

Both games took place prior to the acquisition of G Luka Doncic, as the Lakers last beat the Cavaliers on April 6, 2024.

Lakers vs. Cavaliers Over/Under, Spread

The Cavaliers enter this matchup as 2.5-point favorites, returning a 1.35x payout on PrizePicks Team Picks if they win outright.

The Lakers are road underdogs with a 2.17x payout if they win, via PrizePicks Team Picks.

• Spread: Cleveland Cavaliers -2.5
• Over/Under: 234.5
• Game Winner Payout: Lakers 2.17x | Cavaliers 1.61x

(Team Picks data is live at the time of writing and is subject to change)

Lakers vs. Cavaliers Injury Report

Let’s dive into the full Lakers vs. Cavaliers injury report for Wednesday, via NBA.com.

Lakers Injury Report 

• G Austin Reaves (calf) – OUT

Cavaliers Injury Report 

• G Darius Garland (toe) – OUT
• F Evan Mobley (calf) – OUT

Lakers vs. Cavaliers Numbers to Know

Here are some facts and figures to get you set for Lakers vs. Cavaliers tonight, including insights on our Lakers vs. Cavaliers prediction.

• The Lakers won and covered four of the last five games, including a 3-1 start to the road trip.
• Los Angeles owns a 7-4 record in the past 11 contests against Eastern Conference foes.
• The Cavs covered the second-fewest games (18) in the NBA behind the Magic.
• Cleveland begins a six-game stretch against Western Conference teams; they're 6-4 in their past 10 outings against Western squads.
• The Lakers are the top shooting team in the league, hitting 49.6% of their field goal attempts. 
• Both the Lakers and Cavaliers struggle to defend the 3-point shot. Los Angeles sits 27th at 37.1% and Cleveland ranks 28th at 37.6%.
• The Lakers finished under the total in four straight games before drilling the over of 235.5 points in Monday’s 129-118 win at Chicago.

Lakers vs. Cavaliers NBA Player Picks

Here are three top Lakers vs. Cavaliers picks to target on Wednesday. Key PrizePicks player projections are headlined by three players: Lakers G Luka Doncic, Lakers F LeBron James, and Cleveland G Donovan Mitchell.

Lakers G Luka Doncic vs. Cavaliers Projection: 50.5 PRA

• Doncic continues to lead the league in scoring at 33.8 points per game (PPG).
• In Monday’s win at Chicago, the 26-year old topped the 40-point mark for the eighth time this season with 46 points.
• The Slovenian star passed this projection in six straight road games, posting an average PRA of 57.3. 
• The six-time All-Star hit 40 free throws in the last four games. Cleveland sits 21st in opponent free throw rate at home.

Lakers F LeBron James vs. Cavaliers Projection: 23.5 Points

• James increased his scoring average each month. He began at 16.5 PPG in November, moved to 21.6 PPG in December, and averages 24.8 PPG in January.
• In eight of 13 January games, the four-time NBA champion topped the 24-point mark. 
• The former Cavaliers star shoots worse on the road, converting 48.2% of his field goal attempts and 30.6% from 3-point range.
• In his last visit to Cleveland — October of 2024 — James scored 26 points in a 24-point loss

Cavaliers G Donovan Mitchell vs. Lakers Projection: 32.5 Points

• Mitchell has caught fire of late, averaging 38.0 PPG in the past three contests.
• The man they call Spida converted 41 field goal attempts, his second-best three-game stretch of the season.
• The former Louisville standout put a spell on the Magic for 45 points in Monday’s 114-98 victory. 
• The 29-year old failed to pass this projection in seven of eight games before scoring 33 points in three straight outings.
• In the last 10 games, the Lakers have not allowed an opponent to score more than 33 points.

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The Cavaliers and Lakers each look to stay hot tonight in James’ return to Cleveland.

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