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Iowa vs. Nebraska Prediction on Spread for NCAA Tournament - 3/26/26

Nebraska G Pryce Sandfort reacts to a call vs. Iowa.
AP Photo/Charlie Neibergall

The NCAA Tournament began with 64 teams, but only 16 remain. Eight teams will be in action for Thursday, March 26's four-game slate, including a matchup between the No. 9 Iowa Hawkeyes (22-12) and the No. 4 Nebraska Cornhuskers (28-6) at 7:30 p.m. ET on TBS and truTV.

As 2.5-point favorites on PrizePicks Team Picks, Nebraska enters this game as the favorite to advance to the regional finals in the South region. Will the Hawkeyes pull off their second straight upset to spoil Nebraska’s dream season?

Who could have the advantage in our Iowa vs. Nebraska prediction on the spread? Make your college basketball picks on PrizePicks and PrizePicks Team Picks and earn real money if you’re right, including on game winners, spreads, and totals!

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Iowa vs. Nebraska Prediction, Spread, Over/Under

After grabbing 247 Sports' third-best player in the transfer portal in G Bennett Stirtz, there were lofty expectations for Iowa this season. They went just 23-12 overall and 10-10 in conference play, but that's in the rearview mirror with the Hawkeyes in the Round of 16 for the first time since 1999.

Iowa is coming off a massive 73-72 win over No. 1 seed Florida. It went down to the dwindling seconds, with Iowa F Alvaro Folguerias draining a game-winning 3-pointer.

Beginning the season unranked in the AP Top 25 Poll, Nebraska smashed preseason expectations by earning a No. 4 seed for the NCAA Tournament. 

The Cornhuskers won their first-ever NCAA Tournament game in the first round vs. No. 13 Troy. Apart of the dominant 76-47 win, the Nebraska fanbase swarmed Oklahoma City, creating a home atmosphere. If Husker fans continue to travel at this level, Nebraska could be even tougher to take down.

This team's succeeded with a blend of defense and 3-point shooting. The Cornhuskers' top five players in minutes all shoot at least 32.4% from deep, while four of them shoot above 34.8%. They couple this shooting with elite defense, ranking seventh in adjusted defensive efficiency, according to Bart Torvik.


Iowa vs. Nebraska Spread, Over/Under

The Cornhuskers enter Thursday’s game as 2.5-point favorites, returning a 1.78x payout on PrizePicks Team Picks if they win outright.

The Hawkeyes are the underdogs with a 2.08x payout if they win, via PrizePicks Team Picks.

  • Spread: Nebraska Cornhuskers -2.5 (2.08x payout)
  • Over/Under: 131.5 (1.85x payout on over)
  • Game Winner Payout: Iowa 2.04x | Nebraska 1.78x

Team Picks data is live as of writing and is subject to change.

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Iowa vs. Nebraska Prediction on Spread for NCAA Tournament – 3/26/26

Here are the key stats to know before locking in your Iowa vs. Nebraska prediction on the spread for Thursday, March 26, on PrizePicks.

  • Nebraska finished the regular season 17-14-1 (54.8%) against the spread (ATS), the fourth-best ATS record in the Big Ten.
  • According to KenPom, there is a 3.76 point difference in net rating between these two teams, with Nebraska at +27.15 and Iowa at +23.39.
  • Nebraska is ranked 20th nationally in 2-point field goal percentage (58.1%).
  • Iowa’s defense allows a 54.1% mark from 2-point range, sitting 279th nationally.
  • The Hawkeyes score plenty of points from forced turnovers by ranking 15th in defensive turnover percentage at 20.5%. 
  • That advantage could be neutralized due to Nebraska's 14.4% turnover rate (37th).
  • Based on what we’ve seen from Nebraska fans this tournament, this could feel like a home game for the Huskers, and the Hawkeyes are 5-6-0 (45.5%) ATS on the road.

Make Iowa vs. Nebraska Picks on PrizePicks

Will Nebraska continue its surprise season by dancing into the Round of 8? Or will Iowa continue its exceptional play and pull off yet another classic NCAA Tournament upset? 

You can make your Iowa vs. Nebraska picks on PrizePicks and PrizePicks Team Picks to earn real money. Just pick players, predict More or Less on their projected stats, and cash in if you’re correct. With Team Picks, make predictions on winners, spreads, and over/unders, now available in 35 states

Keep tabs on the Playbook for continued college basketball predictions, picks, and news.

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Team Picks and Culture Picks are event contracts offered by Performance Predictions II, LLC d/b/a PrizePicks Predict, a CFTC-registered FCM and NFA Member. All event contract customers must be U.S. residents and 18+. Some event contracts may not be available in every state. Event contract trading carries significant risk and is not appropriate for everyone. No guarantee against loss is offered. Past results are not necessarily indicative of future results. Void where prohibited by law. Restrictions apply. For full terms of service see prizepicks.com/predict-regulatory. Team and Culture Pick Early Payouts subject to market liquidity. The content provided is for informational and educational purposes only and does not constitute investment advice, or a recommendation to trade any commodity interest.

about the author

Adi Narang is a professional sports bettor and New York University graduate in Sports Management. A lifelong Denver sports fan, he’s spent over a decade applying data-driven analysis to trends, pricing, and game-level predictions. He’s always up for a sports conversation — from a Nikola Jokić GOAT debate to Korean Baseball batting orders.

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