Tonight,we get a Western Conference matchup between the struggling Memphis Grizzlies (4-10) and the San Antonio Spurs (9-4) at 8:00 p.m. ET on NBC.
The last time the Grizzlies and Spurs faced off on March 1, 2025, the Spurs came away with a 130-128 victory thanks to the trio of PG De’Aaron Fox, G Stephon Castle, and F Devin Vassell, who all scored 20+. However, the Grizzlies have the edge in the head-to-head matchup, winning eight of the last ten games and three of the last five.
Below, we’ll break down our Grizzlies vs. Spurs prediction and player picks for Tuesday, including top picks on PrizePicks’ real-money NBA game for De’Aaron Fox and PF Jaren Jackson Jr..
Grizzlies vs. Spurs Prediction, Tuesday NBA Picks
Let’s break down Memphis and San Antonio as they head into tonight's Southwest Division matchup.
Grizzlies Preview vs. Spurs
- The Grizzlies are looking to snap their second four-game losing streak of the season.
- Memphis has fallen from a 117.2 offensive rating last season — sixth in the NBA and the best in franchise history — to 108.4 this year (26th).
- Memphis is severely shorthanded, with Ja Morant (calf), F Brandon Clarke (knee), G Ty Jerome (calf), G Scotty Pippen Jr., and G Javon Small (toe) all out on Tuesday night.
- Without Morant, the Grizzlies lean heavily on C/F Jaren Jackson Jr. and C Zach Edey to create offense — they are 25th in scoring offense (111.9 PPG) with a -7.9 average scoring margin.
Spurs Preview vs. Grizzlies
- The Spurs opened the season with a 5-0 start, the best opening record in franchise history, before splitting their next eight games.
- The fast start was fueled by PF/C Victor Wembanyama's dominance, but the Spurs now face a critical stretch without their All-Star, who is sidelined indefinitely with a left calf strain and expected to miss at least two to three weeks.
- San Antonio has a 117.1 offensive rating this season (10th), a significant jump from last year's 113.5 rating (19th), as the Spurs have leaned on an up-tempo attack and improved spacing around Wembanyama.
- The injuries extend beyond Wembanyama for the Spurs, with rookie G Dylan Harper (calf), Stephon Castle (hip), and G Jordan McLaughlin (hamstring) all ruled out for this Tuesday night matchup.
Grizzlies vs. Spurs Picks for PrizePicks - Tuesday, 11/18/25
Below are three top Grizzlies vs. Spurs NBA DFS picks for Tuesday. Use PrizePicks' real-money NBA game and win real money if your NBA picks are right.
Spurs PG De’Aaron Fox vs. Grizzlies Projection: 25.5 Points
- Fox is rounding into form after his hamstring issues, averaging 22.0 PPG through his first five games of the season with 20+ points in four out of those five
- He led the team with 28 points in his most recent outing against Sacramento.
- The Spurs PG is handling the bulk of the work on offense posting a 27.2% usage rate averaging nearly 17 FGA per game.
- Against Sacramento, Fox led the team with 35 minutes played in their 123-110 victory.
- The matchup is favorable for the 10-year veteran, as Memphis owns a 116.3 defensive rating (20th) and a 1.136 defensive efficiency (20th).
- The former Kentucky Wildcat has a solid history against Memphis with an average of 21.0 PPG in 23 career games.
Grizzlies PF Jaren Jackson Jr. vs. Spurs Projection: 22.5 Points
- Jackson Jr. is averaging 17.9 points through 14 games this season
- The San Antonio Spurs allow a combined 40.9 PPG to the opposing team’s front court.
- The Spurs allow 40.3 PPG in the paint coming into tonight’s matchup. With Wembanyama out of the lineup, they give up44.0 points in the paint against the Sacramento Kings in their most recent outing.
- Tuesday’s game carries a total of 232.5 points — with the Spurs averaging 118.8 PPG — and it will be up to Jackson Jr. to man the offensive load to keep up in a potentially high-scoring affair.
Grizzlies C Zach Edey vs. Spurs Projection: 8.5 Rebounds
- After missing the first 13 games this season due to ankle surgery, Edey made his season debut on November 15th against Cleveland, in which he scored 13 points and grabbed 7 rebounds in 25 minutes.
- The second-year center posted a 17.7% offensive rebounding percentage in his rookie season, and in his final month of the 2024-25 campaign, he led the entire NBA with 15.7 RPG.
- Without Wembanyama (12.9 RPG) protecting the paint, the Spurs are starting PF/C Luke Kornet and relying on backup PF/C Kelly Olynyk, who combine for 9.3 RPG to anchor the defense in the paint.
- The Grizzlies rank 18th in offensive rebounds per game (10.6), but Edey's return could boost those numbers. Memphis has grabbed 9.2 more offensive rebounds per 100 possessions with him on the court last season.
In this Western Conference matchup, there are plenty of options to make your NBA picks on PrizePicks. Just predict More or Less on NBA player projections and win money if you're right.
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