Entering the season, did anyone have the Colts and Chargers sitting as two of the AFC’s top three seeds through six games? If so, it’s time to turn in that magical sports almanac before the teams go head-to-head.
Sunday afternoon (4:05 p.m. ET on CBS) sees 4-2 Los Angeles host 5-1 Indianapolis in a critical intra-conference battle. There’s plenty of star power at the helm for both sides.
Here, we’ll dive into a Colts vs. Chargers prediction and same-game NFL DFS picks for Week 7. Win real-money rewards with PrizePicks when your picks are right!
Colts vs. Chargers Prediction, Preview for Week 7
Sunday is the first clash between the Chargers and Colts since 2022. Week 16 of that season saw QB Justin Herbert throw for 235 yards in a playoff-clinching contest.
Then-Colts starter Nick Foles threw 3 INTs in that game, dropping Indy to 4-10 on the year. They’re in better hands this time around.
Indianapolis Colts Preview
- The Colts pulled the plug on the Anthony Richardson experiment at QB after parts of two seasons, signing Daniel Jones to a $14M deal this offseason.
- Switching to Jones is paying off. Indianapolis boasts its first 5-1 start since 2009, when they ultimately reached Super Bowl XLIV.
- Per SumerSports, head coach Shane Steichen is leading the offense to a league-best 0.18 EPA/play.
- While Indy still boasts a formidable defense, peripherals like success rate aren’t as kind. Entering Week 7, they’ve dropped 12 spots year-over-year, going from 10th to 22nd.
Los Angeles Chargers Preview
- Year one with Jim Harbaugh at head coach went smoothly for Los Angeles, who posted an 11-6 record in 2024, but lost in the opening round of the playoffs.
- This time around, the Chargers are already 3-0 in the AFC West and own possession of first place in the division.
- The year-three breakout of WR Quentin Johnston — 377 receiving yards and 4 TDs — helped L.A.’s offense find its footing.
- As expected, losing star OT Rashawn Slater for the season hurt. Joe Alt was excellent in Weeks 1-4 (and is back at practice), whereas fellow O-linemen Trey Pipkins III and Austin Deculus aren’t faring as well.
Colts vs. Chargers Same Game Picks for NFL DFS & PrizePicks
Below are some top same-game PrizePicks projections to consider for Colts vs. Chargers. Featured offerings include Indianapolis’ QB-RB duo of Daniel Jones and Jonathan Taylor, as well as Los Angeles RB Kimani Vidal.
Colts QB Daniel Jones Projection: 220.5 Pass Yards
- Jones averages a career-high 250.3 passing yards per game. He’s posted exactly 212 in consecutive contests.
- Two elements working in Jones’ favor are efficiency and sack evasion. His 71.7 completion percentage is a personal best, and his 2.70% sack rate leads the NFL.
- The Chargers face the fourth-highest pass rate over expected this season at 2.2%, per Jefe’s Handiwork.
- Los Angeles plays zone coverage more than all but one team but, per SumerSports, Jones ranks seventh in total EPA (29.9) in those scenarios.
- A tendency trend to note, via NFL Pro: Jones has football’s second-most passing yards on play-action (630), but L.A.’s defense yields the fifth-lowest completion rate on such throws.
Colts RB Jonathan Taylor Projection: 89.5 Rush Yards
- Has there been a better RB than Taylor in 2025? Through six games, he leads the sport in attempts (115), yards (603), and TDs (7) on the ground.
- Los Angeles’ run defense ranks 25th in EPA/play and gives up the sixth-most yards per carry (4.7) this season.
- According to Pro Football Focus, Taylor’s 15 explosive runs are more than 21 NFL teams have this year.
- When contacted at or behind the line of scrimmage, Taylor has more than double the next-closest RB’s average yards post-contact (6.80 to Javonte Williams’ 3.3).
- Taylor averages 111.5 rushing yards per game in the afternoon window and 113.8 against AFC West opponents. Both are his best for game time and division faced.
Chargers RB Kimani Vidal Projection: 74.5 Rush + Rec Yards
- In the Chargers’ first full game without rookie RB Omarion Hampton, Vidal out-snapped RB Hassan Haskins 43 to 20.
- Vidal racked up a career-high 124 rushing yards against the Dolphins in Week 6, adding another 14 as a pass catcher.
- The Colts allow the second-highest rush success rate (48%) in the sport, according to rbsdm.com.
- Only two defenses, the Seahawks and the Cowboys, have been targeted more by RBs in the receiving game.
- Indy stacks the box at a lower frequency than anyone (11.2%), which might allow Vidal to break off some chunk runs.
- Courtesy of Fantasy Points Data, 59.1% of Vidal’s season rush attempts are on zone runs. The Colts surrender the fifth-highest yards per carry (4.65) on those tries.
Make Colts vs. Chargers Picks on PrizePicks
Colts vs. Chargers predictions and picks aren’t the only routes to season-long NFL action. With PrizePicks NFL DFS, you can join the fun for all Week 7 games! Doing so is simple.
Pick players, predict More or Less for their stats, then add everything to your Lineup. Win real-money prizes when you’re right!
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