Saturday basketball on ESPN features multiple high-profile matchups, and the opener for the weekend could be one of the best. It’s a classic ACC battle, as the No. 20 Clemson Tigers take on the No. 4 Duke Blue Devils.
The Saturday afternoon bout (12:00 p.m. ET) takes place at Cameron Indoor Stadium in Durham, NC. With both teams ranked and jockeying for conference positioning, this clash may also have significant NCAA Tournament implications.
Below, we’ll break down our Clemson vs. Duke prediction and picks for Saturday’s game. Make your college basketball picks on PrizePicks and PrizePicks Team Picks and earn real money if you’re right, including on game winners, spreads, and totals!
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Rankings and statistics used in this story are listed entering Friday night’s play.
Clemson vs. Duke Prediction, Spread, Over/Under
It’s been a decade and a half since Brad Brownell took over as head coach at Clemson, and his Tigers are off to one of their best starts. Sitting 20-5 through 25 games, Clemson is just a game out of first place in the ACC standings.
Duke, meanwhile, is the current conference leader with an 11-1 ACC record. Head coach Jon Scheyer’s crew is 22-2 overall, with its only defeats being to Texas Tech and North Carolina.
Saturday is the 136th all-time bout between Clemson and Duke since 1949-50. With the Blue Devils owning a commanding 103-32 series lead, including a +9.3 average point differential, Clemson has an opportunity to buck a big-time trend this weekend.
Clemson vs. Duke Spread, Over/Under
Clemson enters Saturday’s game as 13.5-point road underdogs, returning a 6.66x payout on PrizePicks Team Picks if they win outright.
Duke is a home favorite with a 1.07x payout if they win, via PrizePicks Team Picks.
- Spread: Duke Blue Devils -13.5
- Over/Under: 133.5
- Game Winner Payout: Tigers 6.66x | Blue Devils 1.07x
Team Picks data is live at the time of writing and is subject to change.
Clemson vs. Duke Prediction on Spread
Here are some stats to know to help you make your Clemson vs. Duke prediction on Saturday, February 14.
- Duke has yet to lose as a home favorite, sitting 11-0 on the year. Clemson doesn’t have a victory as a road underdog.
- The Tigers’ offense is 159th in per-game scoring (75.6 PPG) and 174th in field goals made each night (26.0).
- Defensively, Clemson limits foes to the 22nd-lowest effective field goal clip (46.6%) but allows 22.5 3-point tries on average.
- Duke puts the ball in the basket at a blistering pace, scoring inside the arc with the fourth-best efficiency (62.2%) in the nation.
- The Blue Devils can also get it done on the other end, suffocating opponents to the tune of just 63.5 PPG, the fourth-fewest among all Division I programs.
Clemson vs. Duke Picks for PrizePicks Today: Saturday, February 14
Here are three top Clemson vs. Duke picks to target for Saturday, February 14 on PrizePicks. Player stat projections via PrizePicks are headlined by F RJ Godfrey, F Cameron Boozer, and G-F Isaiah Evans.
Clemson F RJ Godfrey vs. Duke Projection: 15.5 Pts + Rebs
- After returning to Clemson from Georgia, Godfrey has raised his scoring average to a career-high 11.6 PPG. He’s also canning a scorching 64.9% of his shots.
- In 12 conference games, the Georgia native takes an average of 4.7 free throw attempts, seeing his free throw rate jump to .667.
- Per Bart Torvik, among all Division I players with at least the same usage rate as him (22.9%), Godfrey ranks 14th with a 65.7 true shooting percentage.
- Godfrey’s 12.6% rebounding rate is his highest since 2022, his true freshman year with the Tigers. He’s never owned a higher defensive rebounding share than his 16.9% mark.
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Duke F Cameron Boozer vs. Clemson Projection: 35.5 Pts + Rebs + Asts
- Twenty-four games into his freshman campaign, Boozer puts up a combined average of 37 points, rebounds, and assists.
- Of all players logging 80% or more of their team’s available minutes, Boozer’s eye-popping 66.2 true shooting percentage sits sixth.
- In that same 255-player pool, the projected top NBA Draft pick is sixth with a 12.1% offensive rebounding rate.
- Boozer leads the nation with a 34.7 Player Efficiency Rating, which spikes to an otherworldly 37.1 during ACC play.
Duke G-F Isaiah Evans vs. Clemson Projection: 13.5 Points
- Evans pours in 14.3 points each night, increasing to 16.8 in a dozen conference games.
- Free throws could be a key for Evans on Saturday. Clemson ranks 306th with an opposition average of 74.6% efficiency at the line, and he leads the ACC with 88.3% of his charity stripe attempts falling.
- The sophomore jacks up 14.6 trey-balls per 100 possessions, sixth in the ACC among qualifiers.
- Per CBB Shot Charts, Evans makes 58% of his left-corner 3-pointers and 67% of rim attempts.
Make #20 Clemson vs. #4 Duke Picks on PrizePicks
Clemson vs. Duke picks for ACC ball are just one of many ways hoops fans can get in on the daily college basketball action.
You can make your picks on PrizePicks and PrizePicks Team Picks and earn real money. Just pick players, predict More or Less on their projected stats, and cash in if you’re correct. With Team Picks, make predictions on winners, spreads, and over/unders, now available in 34 states.
Stick around with the Playbook for continued CBB predictions, picks, and news.





