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76ers vs Lakers Prediction, Spread: LeBron-Maxey Throwdown

Lakers F LeBron James lays up a basketball in an NBA game.
AP Photo/Chris Szagola

The Philadelphia 76ers and Los Angeles Lakers, two teams with a storied history with each other, meet on Thursday night in Los Angeles. It’s a matchup with plenty of star power with Joel Embiid and Tyrese Maxey going up against LeBron James and Luka Doncic. The 76ers-Lakers Thursday night game is at 10:00 p.m. ET.

The Sixers, who are 2-0 on a current five-game West Coast trip, have won five in a row overall, and sit in sixth place in the Eastern Conference. The Lakers have won four of their last six games, and are in fifth place in the Western Conference. 

Below, we’ll break down our 76ers-Lakers prediction and picks for Thursday’s game. Make your picks on PrizePicks and PrizePicks Team Picks and earn real money if you’re right, including on game winners, spreads, and totals!

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76ers vs. Lakers Prediction, Spread

The 76ers and Lakers franchises, who have met in the NBA Finals six times, meet for the 295th time in the regular season. The Lakers hold a slim 149-145 edge, including a 4-point win in Philly back in December. This is the second of two meetings this season. 

76ers vs. Lakers Over/Under, Spread

The Lakers enter the Eastern Conference game as 4.5-point favorites, returning a 1.51x payout on PrizePicks Team Picks if they win.

The 76ers are the underdogs with a 2.43x payout if they win, via PrizePicks Team Picks.

  • Spread: Los Angeles Lakers  -4.5
  • Over/Under: 232.5
  • Game Winner Payout: Lakers 1.53x | 76ers 2.38x

Team Picks data is live at the time of writing and is subject to change.


76ers vs. Lakers Prediction on Spread

The Lakers are 4.5-point favorites in the first of an 8-game homestand. 

  • The 76ers have been one of the better NBA teams against the number this season, covering in 29 of 50 games (58%). That’s the third-highest cover percentage in the league. 
  • In addition, Philly is 12-8 this season as an underdog, good for a 60% cover percentage.   
  • The Sixers’ offense has struggled shooting, as they are 24th in the league in FG pct (46.0) and 21st in EFG (53.2). On the defensive side, they are 14th in the NBA in defensive rating at 113.9.
  • The Lakers, on the other hand, lead the NBA in FG pct (49.8%), are second in the NBA in EFG (56.9), and ninth in offensive rating (116.8).
  • The Lakers are 27-22 against the spread this season, going 5-3 ATS during a recent eight-game road trip.
  • L.A. is 19-10 against the number as a favorite this season, the third most covers of any team in that spot, behind the Thunder and Knicks. 
  • The two teams have played among the most overs this season, with the Lakers going over the projected number in 28 of 49 games and the 76ers in 26 of 50 games. Only the Nuggets, Jazz, and Warriors have played more overs. 

76ers vs. Lakers Injury Report

Let’s dive into the full 76ers vs. Lakers injury report for Thursday, via NBA.com 

76ers Injury Report 

  • C Joel Embiid (Knee) - Questionable
  • F Paul George (Suspension) - OUT
  • G Kelly Oubre Jr. (Knee) - Available

Lakers Injury Report

  • C Jaxson Hayes (Suspension) - OUT
  • F Adou Thiero (MCL) - OUT

76ers vs. Lakers Picks for PrizePicks Today: Thursday, February 5

Here are two 76ers vs. Lakers picks to target for Thursday, February 5 on PrizePicks. Player stat projections via PrizePicks are headlined by 76ers G Tyrese Maxey and Lakers F LeBron James

76ers G Tyrese Maxey Projection vs. Lakers: 7 Assists

  • 76ers G Tyrese Maxey has recorded 6+ assists in 34 of 48 games this season, including in 10 of the last 11 games. He’s reached 7 assists 25 times. 
  • Over those six games, Maxey has totaled 81 assists, or 7.4 per game. 
  • The Kentucky product averages 6.8 assists per game, 18h best in the NBA and most on the 76ers. 
  • Maxey’s usage percentage is 27.9, which is 28th in the NBA and 18th among guards.

Lakers F LeBron James Projection vs. 76ers: 5.5 Rebounds

  • Lakers F LeBron James has failed to reach his rebound projection in five straight and in seven of the last nine games.
  • In his first 27 games of the season, James averaged 6.03 rebound per game, compared to 3.8 over the last five games. 
  • For his career, James averages 7.5 rebounds per game and has finished every season, except his rookie year, with at least 6.0 rebounds a game.
  • The future Hall-of-Famer has averaged 27.2 points, 7.2 rebounds, and 8.0 assists in 59 career games vs. the 76ers.  

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Make 76ers vs. Lakers NBA Picks on PrizePicks

Can the 76ers continue their winning ways and climb up the Eastern Conference Standings with a second road win in L.A. this week? Or will the Lakers start their eight-game homestand off with a win? The 76ers-Lakers Thursday, February 5th game is at 10:00 p.m. ET. 

You can make your 76ers vs. Lakers picks on PrizePicks and PrizePicks Team Picks to earn real money. Just pick players, predict More or Less on their projected stats, and cash in if you’re correct. With Team Picks, make predictions on winners, spreads, and over/unders, now available in 34 states

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Team Picks and Culture Picks are event contracts offered by Performance Predictions II, LLC d/b/a PrizePicks Predict, a CFTC-registered FCM and NFA Member. All event contract customers must be U.S. residents and 18+. Some event contracts may not be available in every state. Event contract trading carries significant risk and is not appropriate for everyone. No guarantee against loss is offered. Past results are not necessarily indicative of future results. Void where prohibited by law. Restrictions apply. For full terms of service see prizepicks.com/predict-regulatory. Team and Culture Pick Early Payouts subject to market liquidity. The content provided is for informational and educational purposes only and does not constitute investment advice, or a recommendation to trade any commodity interest.

about the author

David Bearman spent 18 years with ESPN in their Stats & Information Department and overseeing their betting content. From 2023-25, he served as Chief Content Officer of Pro Football Network, overseeing all content, including coverage of Super Bowls 58 and 59. He is also the Founder of Betting with Bearman, a 3x a week betting newsletter and weekly podcast on Bleav Podcast Network.

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