Game 2 of the Philadelphia 76ers vs. New York Knicks NBA Playoff series is set to tip off at 9:30 p.m. ET on Wednesday, May 6, with the Knicks entering as 7.5-point favorites on the spread, via PrizePicks.
The Knicks continued their dominant postseason play with a 39-point beatdown in Game 1 on Monday, winning every quarter by 8+ points. With that said, the 76ers suffered a 32-point loss in Game 1 of their last series against the Boston Celtics and responded with a road win. Can they do the same tonight?
Below, we'll break down our 76ers vs. Knicks prediction and picks for Wednesday’s NBA Playoff game, including the spread, over/under, and key player picks for PrizePicks.
Make your picks for 76ers vs. Knicks on PrizePicks now.
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76ers vs. Knicks Prediction, Spread, Over/Under for Game 2 – Wednesday, May 6
The 76ers will need to have a short memory going into Game 2 tonight.
One positive of a blowout loss is that star C Joel Embiid got some in-game rest, as he played only 25 minutes on Monday. Perhaps he can parlay that into a more dominant effort tonight, as a 3-for-11 outing like in Game 1 just won’t cut it going forward.
Philly did get to the line 34 times and shot a respectable 37% from 3-point range in the series' first game. SF Paul George seems to be turning back the clock, too, and rookie SG VJ Edgecombe has stepped up multiple times this postseason.
The Knicks picked a great time to be playing their most impressive basketball. They're moving as a collective on defense while playing free-flowing offense with seemingly every guy shooting the lights out. New York shot 63% from the field and 51% from 3-point range in Game 1 and felt as though it could get whatever it wanted at any time.
PG Jalen Brunson poured in 35 points on 12-of-18 shooting, while forwards Mikal Bridges and OG Anunoby scored 35 combined points on 14-for-18 shooting.
If the Knicks can keep up their recent level of play, perhaps they can reach the NBA Finals for the first time since 1999.
76ers vs. Knicks Spread, Over/Under for Game 2 – Wednesday, May 6
The Knicks enter Wednesday’s game as 7.5-point home favorites against the 76ers, returning a 1.33x payout if they win outright, via PrizePicks Team Picks.
Here are the full payouts for the 76ers vs. Knicks game on PrizePicks.
- Spread: New York Knicks -7.5 (1.81x payout)
- Over/Under: 214.5 (1.75x payout on Over)
- Game Winner Payout: 76ers - 3.12x | Knicks - 1.33x
Play the 76ers vs. Knicks spread or over/under on PrizePicks Team Picks to earn real money — available in 35 states!
Team Picks data is live at the time of writing and is subject to change.
76ers vs. Knicks Prediction on Spread for Game 2 – 05/06/26
Here are the key game stats and trends behind our 76ers vs. Knicks prediction on the Spread for Wednesday, May 6.
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- The Knicks are now a dominant 30-14 (68.2%) against the spread (ATS) at Madison Square Garden, by far the best home ATS record in the NBA.
- New York also owns the best net rating in the NBA Playoffs at +21.4.
- The 76ers are 13th in net rating (-7.7) among all 16 playoff teams.
- New York has a massive advantage on the glass tonight. During the regular season, the Knicks were fifth in total rebounding percentage (52.2%), well above the 76ers at 21st (49.2%).
- The Knicks' one weakness defensively is allowing opponents to shoot 36.2% from deep (20th) on 38.4 attempts each night (22nd).
- The 76ers aren’t built to exploit this defensive weakness, however, as they generate just 31.9% of their total points from 3-point land (22nd).
76ers vs. Knicks Player Picks, Stats for PrizePicks – 05/06/26
Here are the top 76ers vs. Knicks picks to target on PrizePicks for Wednesday, May 6. Today’s NBA picks for PrizePicks include PGs Tyrese Maxey and Jalen Brunson.
76ers PG Tyrese Maxey vs. Knicks Projection: 34.5 Pts + Rebs + Asts
- Maxey had more than this projection in three of his four regular-season matchups against the Knicks.
- New York's struggles against the 3-ball may not hit the same for the team, but that could benefit Maxey, who's shooting 36.7% from deep on 8.6 attempts each night.
- Maxey has performed better on the road this season, averaging 1.9 more points, 0.7 more rebounds, and 0.2 more assists away from home.
- Tyrese could spend a fair amount of time being guarded by opposing PG Jalen Brunson who, with a defensive rating of 114.1, is the Knicks' worst-graded stopper.
Add Tyrese Maxey to your PrizePicks Lineup now.
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Knicks PG Jalen Brunson vs. 76ers Projection: 36.5 Pts + Rebs + Asts
- This is a nice tempo-up game for Brunson and the Knicks, who are bottom five in the NBA in pace. Philadelphia is 15th, right down the middle.
- Brunson has cooked at home all season, averaging 2.3 more points and 0.2 more assists per game at MSG.
- The star PG had more than this projection in three of his four regular-season matchups against Philadelphia this season.
- During the regular season, the 76ers gave up the ninth-most rebounds (45.3) and assists (27.6) per game.
- Brunson's primary assignments could be Maxey and Edgecombe. They both have defensive ratings above 113.
Add Jalen Brunson to your PrizePicks Lineup now.
NBA Playoffs Live Picks: 76ers vs. Knicks on PrizePicks for Game 2
Here are some in-game angles to target for your 76ers vs. Knicks live picks in tonight’s game.
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- If the Knicks win, it could be because Brunson is making his outside shots. The All-Star PG is shooting 39.8% from deep in wins but just 31% in losses.
- Keep an eye on the third quarter. During the regular season, the 76ers had the worst net rating in the NBA in the third frame at -10.6.
- New York is known for closing games out. The Knicks had the NBA’s best fourth-quarter net rating this season (+11.7), 3.7 points ahead of the second-place Detroit Pistons.
- Expanding on that, both the 76ers and Knicks play their most uptempo ball in the final quarter of action.
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Will the Knicks' recent postseason dominance continue tonight, or will Philly rebound and steal home-court advantage with a big road win in the Garden?
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