While four teams are on a bye during Week 5, there are still plenty of matchups on which to focus across the NFL. Jets QB Justin Fields could shine in a battle with a Cowboys defense that has been unable to stop anyone. And Dolphins star RB De’Von Achane could put the team on his back against the Panthers with Dolphins WR Tyreek Hill (knee) out for the season.
Below, we'll discuss Achane, Fields, and seven other NFL DFS picks for Week 5, including some picks for PrizePicks.
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Week 5 NFL DFS Quick Picks for PrizePicks
Here are some quick PrizePicks DFS picks for NFL Week 5, including projections for pass yards, rush yards, and receiving yards.
Jets QB Justin Fields vs. Cowboys Projection: 187.5 Pass Yards
- Despite being known for his rushing prowess, Fields has thrown for at least 218 yards in two of his three games with the Jets.
- The Cowboys have allowed 9.2 yards per pass attempt, the highest mark in the NFL.
Giants RB Cam Skattebo vs. Saints Projection: 67.5 Rush Yards
- With Giants RB Tyrone Tracy Jr. (shoulder) out in Week 5 against the Chargers, Skattebo turned 25 carries into 79 yards.
- The Giants rookie is difficult to bring down, leaving him with a 72.9% positive run rate.
Dolphins WR Jaylen Waddle vs. Panthers Projection: 61.5 Receiving Yards
- Hill’s absence could create more opportunities for Waddle as the Cheetah saw 29 targets through four games.
- Prior to this season, Waddle had averaged at least 12.8 yards per reception in each of the last three seasons.
Week 5 NFL DFS Picks for PrizePicks
Here are the top NFL DFS picks for NFL Week 5. Player projections via the PrizePicks real money NFL game.
Dolphins RB De’Von Achane vs. Panthers Projection: 15.5 Rush Attempts
- With Hill hitting the trainer's room after his Week 4 injury, Achane received a season-high 20 carries against the Jets. He finished with 99 rushing yards and 1 TD.
- Hill has only missed one game during his career with the Dolphins. In that game, Achane, RB Raheem Mostert and RB Jeff Wilson Jr. combined for 26 carries.
- Dolphins backup RB Ollie Gordon has not been efficient, averaging just 3.3 yards per carry.
- The Panthers have allowed the sixth-most rushing yards per game in the league.
Cardinals QB Kyler Murray vs. Titans Projection: 21.5 Pass Completions
- Murray has completed 21, 17, 22, and 27 passes over four games in 2025.
- The former first overall pick has a 66.9% completion rate this season. For his career, he has completed 67.0% of his pass attempts.
- Injuries might force the Cardinals to rely more on their passing attack moving forward. Cardinals RB James Conner (foot) is already out for the season, and now Cardinals RB Trey Benson (knee) joins him on injured reserve.
- The Cardinals' top two remaining running backs are Emari Demercado and Michael Carter. Since the start of 2023, the two have combined for only 130 carries.
- The Titans have allowed the sixth-highest completion rate (69.8%) in the league.
Chargers WR Quentin Johnston vs. Commanders Projection: 58.5 Receiving Yards
- After recording an average depth of target of 10.9 yards last season, Johnston has an aDOT of 13.0 yards here in 2025.
- Another big difference for the third-year receiver is that his target share is up to 25.5%, compared to 18.3% last season.
- With his increased workload and ability to catch the deep ball, Johnston already has 7 receptions of at least 20 yards.
- Johnston finished with 98 receiving yards versus the Giants in Week 4 and has posted at least 71 receiving yards in all four games this season.
- The Commanders struggle to limit big plays. They have given up 13 passes of at least 20 yards and have allowed 8.6 yards per pass attempt, the third-highest mark in the league.
Cowboys TE Jake Ferguson vs. Jets Projection: 5 receptions
- Ferguson has recorded at least 7 receptions in each of his last three games.
- In the last two outings, he has caught 20 of 21 targets with WR CeeDee Lamb (ankle) sidelined.
- The Cowboys' star tight end has seen 23.4% of their targets, and he has been targeted on 30.2% of his routes run.
- The University of Wisconsin-Madison product scored his first touchdown of the season in Week 4 and has seen 3 targets inside the red zone over the last two games.
- In his first game back after sitting out an entire season, Dolphins TE Darren Waller caught 3 of 4 targets for 27 yards and 2 TDs against the Jets in Week 4.
Giants WR Darius Slayton vs. Saints Projection: 41.5 Receiving Yards
- Slayton has recorded at least 44 receiving yards in two of the last three games.
- While he only has 13 targets for the season, he could be asked to carry a heavier workload with WR1 Malik Nabers out (ACL) for the season
- When Nabers missed a Week 5 matchup with the Cowboys last season, Slayton caught 8 of 11 targets for 122 yards and 1 TD.
- With Nabers sidelined for Week 6 against the Bengals last year, Slayton posted 6 receptions for 57 yards on 11 targets.
- The former fifth-round pick averaged at least 14.7 yards per reception in five of his first six seasons in the NFL. This year, he has averaged 15.0 yards per catch.
Saints RB Kendre Miller vs. Giants Projection: 28.5 Rush Yards
- Miller is coming off his best game of the season, turning 11 carries into 65 yards and 1 TD against the Bills in Week 4.
- Despite not getting more than 7 carries in any of his first three games, Miller finished with at least 24 rushing yards on two occasions.
- Per RotoWire, Miller has a broken tackle rate of 39.3% and has averaged 3.8 yards after contact.
- The Giants have been chewed up on the ground, allowing 6.1 yards per carry.
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Injuries and bye weeks will make for a tricky Week 5 slate. On the quarterback side of things, Fields and Murray could be busy, while in terms of running backs, Achane and Skattebo have the potential for more work on the ground with their star wide receivers out. Waddle and Slayton could also see more action.
With a bevy of projection categories to consider, now is the time to build your NFL Lineup on PrizePicks. Just pick More or Less for at least two NFL player stat projections to build your Lineup on PrizePicks. Check out the Playbook for more NFL DFS picks and analysis all the way through the season.
