Thanksgiving is about family, food, and football. The NFL brings three excellent games to the table this Thanksgiving, beginning with a matchup between the Packers vs. Lions at 1 p.m. ET on FOX. That will be followed by the Cowboys hosting the Chiefs at 4:30 p.m. ET on CBS. Finally, the Bengals will get back QB Joe Burrow vs. the Ravens to close out the day at 8:20 p.m. ET on NBC.
Below, we'll break down the top PrizePicks NFL picks in all three Thanksgiving games, including Bengals WR Ja’Marr Chase and Chiefs QB Patrick Mahomes leading the way on a star-studded slate.
With four of the top 10 ranked offenses in EPA per play playing on this Thanksgiving slate — plus Lamar Jackson and Joe Burrow battling it out on Thursday Night Football — there's plenty of high-upside options for your Turkey Day Thanksgiving Lineups.
Top PrizePicks Picks for NFL Thanksgiving Games
Here are the top PrizePicks picks across all three NFL Thanksgiving games. Player projections are via PrizePicks NFL game — pick More or Less on player stats to win real cash if you're right.
Bengals WR Ja’Marr Chase vs. Ravens Projection – 92.5 Receiving Yards
- Chase will make his return from a one-game suspension that was a result of an incident that he had with Steelers CB Jalen Ramsey in Week 11.
- The Bengals are expected to get back QB Joe Burrow (toe), who has been sidelined since Week 3.
- While Burrow and Chase are coming back, the Bengals will be without WR Tee Higgins (concussion).
- Chase has recorded at least 90 receiving yards in six of his 10 games.
- The Ravens have given up the seventh-most receptions to wide receivers (142) in the league.
Chiefs QB Patrick Mahomes vs. Cowboys Projection – 267.5 Pass Yards
- Although he didn’t record a touchdown pass, Mahomes threw for 352 yards versus the Colts in Week 12.
- The Chiefs’ superstar quarterback has logged at least 276 yards through the air in four of his last five games.
- Four QBs have surpassed this passing yards number vs. the Cowboys in 2025.
- Mahomes has an average target depth of 8.3 yards, which is up from just 6.3 yards last season.
- The Cowboys have permitted 7.84 yards per pass attempt, which is tied for the third-highest mark in the NFL.
- Dallas' defense ranks 27th in expected points added per dropback (0.18) this year.
Ravens RB Derrick Henry vs. Bengals Projection – 18 Rush Attempts
- Henry reached the end zone two times against the Jets in Week 12. He also ran for 64 yards over his 21 carries.
- That marked the sixth straight game in which Henry finished with at least 18 rushing attempts.
- The last three games came with Jackson under-center after he returned from injury.
- The former second-round pick leads the Ravens with 187 rushing attempts this season. The running back with the next most on the team is Keaton Mitchell, with 23 carries.
- The Bengals have been run on 281 times this season, which is the third-most in the league.
- Teams attack their run defense because they have allowed 5.13 yards per carry to running backs.
- In his two games vs. the Bengals as a member of the Ravens, Henry is averaging 15.5 carries per game.
Chiefs WR Rashee Rice vs. Cowboys Projection – 73.5 Receiving Yards
- Rice caught 8-of-12 targets for 141 yards against the Colts last week.
- Since returning from suspension, Rice has logged at least 80 receiving yards in three of five games.
- The 25-year-old is averaging 9.4 targets per game.
- Using his per-game averages this year, Rice would be on pace for 115 receptions, 1,340 receiving yards, and 11.6 TDs in a 17-game season.
- Dallas has given up 9.75 yards per target to wide receivers, which is second to only the Commanders (9.81).
- Despite having a lackluster average depth of target of 5.5 yards, Rice is averaging 7.9 yards after the catch.
Lions WR Amon-Ra St. Brown vs. Packers Projection – 76.5 Receiving Yards
- Lions TE Sam LaPorta (back) is on injured reserve and likely won’t return this season, opening up additional target share in the No. 9 ranked offense in EPA/play.
- Over the last two games without LaPorta, St. Brown has been targeted a total of 25 times.
- Although St. Brown only caught 2-of-12 targets for 42 yards in Week 11 versus the Eagles, he got back on track with 9 receptions for 149 yards and a TD against the Giants last week.
- The former fourth-round pick has accounted for 42.6% of the Lions’ air yards.
- Despite his success this year, St. Brown has been kept in check by the Packers in his career; he has gone for 60+ receiving yards just twice in nine games vs. the division rivals.
Ravens TE Mark Andrews vs. Bengals Projection – 41.5 Receiving Yards
- Andrews only has one game this season in which he finished at least 40 receiving yards, which came in Week 3 against the Lions.
- Last week, the Jets held the veteran tight end to 1 catch for 9 yards.
- Despite Andrews’ underwhelming production, the Bengals are a great matchup for tight ends. They have allowed the most receptions (76), receiving yards (962), and touchdowns (13) in the league to tight ends — by a wide margin.
- Last season, Andrews finished with at least 4 receptions and 55 receiving yards in both of his meetings with the Bengals.
- Andrews' 1.24 yards per route run are a career low in his age-30 season; his next lowest was 2024, with 1.88.
Make Thanksgiving NFL Picks on PrizePicks
On a star-studded Thanksgiving NFL slate, star players are in ideal spots to stuff the stat sheet. Mahomes will look to exploit the Cowboys’ lackluster pass defense, with Rice lined up to be one of his top targets. Other wide receivers who could thrive with additional targets include Chase (without Higgins) and St. Brown (without LaPorta).
Meanwhile, Henry could be given another heavy workload for the Ravens, while his teammate Andrews also gets a soft matchup vs. the Bengals, despite his underwhelming season thus far.
With Thanksgiving NFL games around the corner, now is the time to build your NFL Lineup on PrizePicks. Just pick More or Less for at least two NFL player stat projections and win real money if you're right. Check out the Playbook for more NFL DFS picks and analysis all the way through the 2025 season.
