This week’s Seattle Seahawks vs. Jacksonville Jaguars matchup is sure to get the blood flowing, and you can tune in at 1 p.m. ET on FOX to watch. Seattle (3–2) heads into Week 6 looking to bounce back after a wild 35–38 loss to Tampa Bay, while Jacksonville (4–1) enters in high gear, fresh off a dramatic Monday night win over the Kansas City Chiefs.
Injuries are also shaking things up: Seattle is hoping to get CB Devon Witherspoon and DE DeMarcus Lawrence back this weekend, which could provide a crucial boost to their defense if they return to the lineup. Meanwhile, the Jaguars just placed TE Brenton Strange on IR. His absence may force the Jaguars to adjust their offensive sets and could test their ability to maintain an effective passing game.
With the stage set, let's break down our Seahawks vs. Jaguars matchup preview, dive into top PrizePicks projections and picks, and highlight the key players to watch this Sunday.
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Seahawks vs. Jaguars Prediction, Picks
Let’s break down both sides of this Seahawks vs. Jaguars matchup by digging into the numbers from the 2025 season to help guide your prediction for Sunday’s game.
Jacksonville Jaguars Preview vs. Seahawks
Although QB Trevor Lawrence has not been able to get his two best wide receivers, Brian Thomas Jr. and Travis Hunter, in sync so far this season, the duo had moments of upside in last week’s game against the Chiefs. Thomas caught a 33-yard pass in the waning moments of the fourth quarter to put the Jaguars in position to score, and Hunter shone on both sides while catching a 44-yard downfield shot.
The Jaguars are fighting through some injury issues of their own. Several contributors have not practiced or practiced only in a limited fashion so far this week: newly-acquired CB Greg Newsome, S Eric Murray, DE Travon Walker, WR Dyami Brown, and RB Bhayshul Tuten. These injuries could affect the Jaguars’ rotation and depth on both sides of the ball, potentially limiting substitutions and special teams options.
Tied with the Indianapolis Colts atop the AFC South, Jacksonville’s best chance of winning this football game could come through their offensive line play. Through five weeks, they have the only offensive line unit in the NFL that ranks top-three in both Run Block Win Rate and Pass Block Win Rate. This could work in their favor against the Seahawks, who rank in the top five in both of the opposite categories.
Seattle Seahawks Preview vs. Jaguars
This is an intriguing matchup for the Seahawks, who have been the NFL’s most run-heavy team through five weeks but now face a Jaguars defense that has been great against the run, allowing the second-fewest carries to RBs and the seventh-lowest yards per carry number. They haven’t allowed a single running back to surpass 57 rushing yards in a game this season.
On offense, the Seahawks will undoubtedly try to run the ball as much as usual, but Seattle QB Sam Darnold could find himself having to throw more than normal. Despite them preferring to run, the Seahawks may actually be fine in throwing more, given that Darnold’s favorite target, star WR Jaxon Smith-Njigba, is the league’s best receiver versus zone coverage this season.
Smith-Njigba boasts an outrageous 34% target share vs. zone coverage shells and ranks first among wide receivers in Fantasy Points per Route Run, according to PFF. He has consistently gone above and beyond when the Seahawks have called his number this season, and with the Jaguars trading away top CB Tyson Campbell, Smith-Njigba will not have the Jaguars’ best CB guarding him.
Seahawks RB Zach Charbonnet Projections vs. Jaguars: 7.5 Yards Longest Reception
Charbonnet has had more than this projection in his last two games after not having a single reception in his first three games. The Jaguars have allowed nine different running backs and at least one in every game to have more than eight yards on their longest reception.
The Seahawks’ second-year RB has seen checkdowns on second/third-and-long situations more frequently this season. The Jaguars blitz at a league-average number, but the Seahawks have seen Darnold blitzed on 35.2% of his dropbacks, which ranks fourth in the NFL.
Jaguars RB Travis Etienne Jr. Projections vs. Seahawks: 15.5 Rushing Attempts
Etienne Jr. has reclaimed the Jaguars’ RB1 job in the weeks following the trade of RB Tank Bigsby, but the curious stat I continue to look at is his rushing attempts.
Despite winning four of their first five games, the Jags only gave Etienne Jr. more than 16 carries in one game, a dominant win over the Panthers. The Seahawks have only allowed two RBs to have more than this projection.
Make Seahawks vs. Jaguars Picks on PrizePicks
The Seahawks travel across the country to Jacksonville for a clash between two playoff-caliber squads looking to stay near the top of their respective divisions.
Seattle has shown flashes of dominance behind a balanced offense and steady quarterback play, while the Jaguars have been grinding out wins behind a tough defense and Travis Etienne Jr.'s all-around production.
This matchup sets up perfectly for some PrizePicks action on Sunday’s slate — including Seahawks vs. Jaguars.
With a full board of projections, you can pick your favorite More or Less lines and build your lineup to win real money this NFL weekend.
