Three weeks into the NFL season, the NFC West is the only division in which all four teams boast winning records. That'll change by evening's end, as Week 4 kicks off with a divisional clash between the Seattle Seahawks and the Arizona Cardinals.
The Thursday Night Football contest (8:15 p.m. ET, Prime Video) features plenty of big-time names who could put up some big-time numbers, among them Seahawks QB Sam Darnold and Cardinals TE Trey McBride.
Below, we’ll drop our Seahawks vs. Cardinals prediction and picks to consider. Make your Week 4 predictions with PrizePicks NFL DFS for a chance to win real-money rewards!
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Seahawks vs. Cardinals Prediction, Thursday Night Football Preview
- Tonight's rumble marks the 53rd time the Seahawks and Cardinals have met dating back to 1976.
- The series advantage goes to Seattle, who own a 29-22-1 edge.
- As recently as 2021, the rivalry was all knotted up. Since then, the Seahawks have rattled off seven straight victories with a +78 scoring margin.
Seattle Seahawks Preview
- After leading the Seahawks to a 10-7 record in his debut season, head coach Mike Macdonald has his squad off to a winning start early in 2025.
- Seattle’s identity is defense. Entering Week 4, they rank first in points per drive allowed and fourth in turnovers generated.
- Following a close 17-13 loss to the 49ers in Week 1, the Seahawks have blowout dubs over the Steelers (31-17) and Saints (44-13).
Arizona Cardinals Preview
- Things continue to move in the right direction for the Cardinals under head coach Jonathan Gannon. They went from 4-13 in 2023 to 8-9 in 2024 prior to their hot 2025 launch.
- That isn’t thanks to QB Kyler Murray realizing his potential, either. Arizona is dead last in pass attempts through three games, which is why they're leaning into running the ball (fourth in both carries and yards).
- With James Conner out for the year, Trey Benson takes over as RB1.
- Unlike the Seahawks, the Cardinals won their first two outings before dropping a close one — 16-15 to the undefeated 49ers — in Week 3.
Seahawks vs. Cardinals Same Game Picks for NFL DFS & PrizePicks
Below are three of the best Seahawks vs. Cardinals same-game NFL DFS picks for Week 4. Thursday Night Football’s showing features PrizePicks player projections to watch for Sam Darnold, Jaxon Smith-Njigba, and Trey McBride.
Seahawks QB Sam Darnold Projection: 221.5 Pass Yards
- After years of underperforming, Darnold broke out with the Vikings last season, throwing for 35 TDs en route to a 14-3 record in his lone campaign.
- Following a career-high per-game average of 254.1 passing yards in 2024, Darnold’s number is down to 221.0 to start 2025.
- In six career Thursday Night Football games, Darnold has averaged 193.5 passing yards.
- The 28-year-old’s current efficiency is through the roof: He ranks second in completion percentage over expectation, fourth in turnover-worthy play rate, and eighth in EPA/play.
- A whopping 81% of Seattle’s rush attempts have been on early downs, but Arizona’s early-down run defense is spectacular. That strength-on-strength matchup might lead to more passing attempts from Darnold.
Seahawks WR Jaxon Smith-Njigba Projection: 84.5 Receiving Yards
- In what's becoming a breakout year, JSN is posting career-best marks in yards per reception (14.7), yards per target (11.1), and catch rate (75.9%).
- Football’s early-season race for the best fantasy wideout is between Smith-Njigba and Puka Nacua, as they’re posting the highest yards per route run (YPRR) in Fantasy Points Data’s tracking history.
- When things break down, the OSU product is Darnold’s security blanket. Targeted on a staggering 38.5% of routes when Darnold is under pressure, he’s averaging 5.12 YPRR.
- In four games against the Cardinals, Smith-Njigba averages 59.0 yards. Last year saw him put up efforts of 77 and 82 yards, scoring in both contests.
Arizona Cardinals TE Trey McBride Projection: 67.5 Receiving Yards
- As goes McBride, so goes the Cardinals’ passing game. The fantasy beast is one of two TEs to hold a target share of 20% or higher with an average of 2.0 or more yards per pass attempt. Colts rookie Tyler Warren is the other.
- If there’s one weakness in this current Seahawks defense, it’s stopping tight ends. They’ve surrendered the most receptions, most TDs, and seventh-most yards to the position.
- McBride averages 10.64 yards per reception and 44.3 yards per game against the Seahawks.
- His best game of 2024 was in Seattle, when he hauled in 12 passes for 133 yards. Both tied or marked the highest totals of his career.
Make Seahawks vs. Cardinals Picks on PrizePicks
Week 4 is chock-full of exciting matchups at the team level. Adding the fun of NFL DFS player picks on PrizePicks takes it next level.
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