Week 4 Thursday Night Football features a pivotal matchup as RB Trey Benson and the Arizona Cardinals host the Seattle Seahawks at State Farm Stadium on Thursday, Sept. 25, at 8:15 p.m. ET.
The Cardinals will shift to Benson as the lead back after RB James Conner suffered a season-ending foot injury in Week 3.
Let’s break down Trey Benson's projections and picks on PrizePicks, where you can win real money with your NFL picks in every game, including Thursday Night Football.
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Trey Benson to Start at RB vs. Seahawks
Conner has been a mainstay over the last five years for the Cardinals, but Benson — the 2024 third-round pick from Florida State — is now tasked with taking over the backfield.
Benson has already impressed as a runner-receiver in 2025— totaling 125 rushing yards on 21 carries (6.0 YPC) and adding 8 receptions on 11 targets across 42 routes.
Benson never had more than 10 carries in a game in 2024, but he averaged 4.6 yards per carry.
Benson’s as prepared as any RB could be in this situation, having already handled early-down and red-zone opportunities even with Conner available through three games.
He has played 87 total snaps to Conner’s 93, as the Cardinals were already looking to shift more play time to their young back.
That said, Arizona faces a stout Seahawks defense that has yet to allow a rushing TD this season and ranks fourth in rush defense expected points added, per rbsdm.
Trey Benson Projections vs. Seahawks Tonight
Here are Trey Benson's projections for Thursday Night Football, via the PrizePicks NFL real money game. Find the top Thursday Night Football picks for Benson below.
Trey Benson Projection: 57.5 Rushing Yards
- Benson is now the primary back for Arizona, averaging 6.0 YPC, third behind David Montgomery (6.9) and Miles Sanders (6.1) in the NFL. That signals strong efficiency rather than just volume.
- Benson ranks seventh in yards after contact per attempt, at 4.05 yards per rush, per PFF.
- The Seahawks have allowed 90 rushing yards per game (seventh-lowest in the NFL), meaning Benson has a realistic floor but will need to convert a few long runs.
- Benson ranked fifth in the NFL this season in longest rush at 52 yards.
- Last season, Benson averaged 6.0 YPC against Seattle in limited usage.
Trey Benson Projection: 21.5 Receiving Yards
- Benson appeared on 24 offensive snaps as a receiver in Week 3.
- He’s hauled in 8-of-9 targets through three games in 2025.
- Benson's role as a pass catcher has expanded in 2025, as he had only six targets all year in 2024.
- Cardinals HC Jonathan Gannon reiterated how “confident” he is in Benson’s bell-cow potential — which includes passing downs.
- In his junior year at Florida State, Benson had only two games out of 13 with more than 21 receiving yards — in both games he had a single catch for over 21 yards.
- He averaged 1.88 yards per route run when he saw 5 targets in Week 2 vs. the Panthers.
- Benson averages 5.4 yards after the catch per reception, showing he can turn check-downs into meaningful gains.
- Benson owns a 12.4% target share in the Cardinals offense, positioning him as the clear passing-down option behind Trey McBride and Marvin Harrison Jr.
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If Benson delivers in a tough divisional matchup on Thursday night, it'll be a huge boost for this Cardinals offense. The second-year RB out of Florida State could solidify himself as the team’s featured back for the rest of the season.
No matter what you think will happen on Thursday Night Football, you can cash in on your predictions on PrizePicks, including Benson in his first start and WR Marvin Harrison Jr.
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