A part of Sunday’s three-game Wild Card slate, the San Francisco 49ers (12-5) will pay a visit to the Philadelphia Eagles (11-6) in Lincoln Financial Field.
Despite carrying one more win than the Eagles, the 49ers are significant underdogs on the road, in part due to injury troubles. Let’s make a deeper dive into Sunday’s 4:30 p.m. ET matchup on FOX. What may we expect from a collision between two of the NFC’s best?
Below, we’ll make a 49ers vs. Eagles prediction and picks for the Wild Card Round, featuring PrizePicks and PrizePicks Team Picks trends to consider.
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49ers vs. Eagles Prediction, Spread, Over/Under
The injury report is likely causing some sleepless nights for the Niners, as San Francisco WR Ricky Pearsall (knee/ankle), LT Trent Williams (hamstring), LB Dee Winters (ankle), LB Luke Gifford (quad), and CB Renardo Green (ankle) are questionable. For the Eagles, Philadelphia RT Lane Johnson (foot) is the only questionable starter.
According to PrizePicks Team Picks, Philly has a 7.69x payout to win the Super Bowl (tied as fourth-favorite), and the Niners carry a 16.66x payout (tied for fourth-highest).
49ers vs. Eagles Over/Under, Spread
While the two teams sport similar records, the Eagles are clear 6.5-point favorites for Sunday’s matchup on PrizePicks Team Picks.
The 43.5 total points to a low-scoring affair, and the under is 7-3 over Philadelphia’s previous 10 games.
- Spread: Philadelphia Eagles -6.5
- Over/Under: 43.5
- Game Winner Payout: 49ers 2.85x | Eagles 1.36x
Team Picks data is live as of writing and is subject to change.
49ers vs. Eagles Prediction on Spread
San Francisco may have its fingers crossed, hoping to return to major pieces in Pearsall and Williams. However, the Eagles’ defense could pose problems regardless, yielding only 6.4 yards per passing attempt (fifth).
The 49ers’ offense heavily leans on the pass, recording 3.8 yards per carry (30th) and 7.5 yards per throw (ninth). Furthermore, San Fran touts 0.16 EPA per dropback (tied for sixth) compared to -0.04 EPA per rush (T-21st), per SumerSports.
According to Pro Football Focus, the Eagles are sixth in pass rush grade, and the Niners sit 18th in pass block grade. If Williams is out — he has a 91.5 PFF player grade — Philly could terrorize San Francisco QB Brock Purdy.
The 49ers’ signal-caller has battled turnover woes, throwing 10 INTs in nine starts with a pick in three straight outings. That’s yet another check mark for Philly, which has a +0.4 turnover margin (seventh) compared to San Fran’s -0.4 mark (26th).
Even the run game could be an advantage for the Eagles, who lean on their 47.3% rush-play rate. The 49ers are susceptible on the ground, ceding 4.3 yards per carry (20th) and -0.01 EPA per rush (T-20th).
Advantages in the turnover and run game departments might just mean a comfy win for the home team.
49ers vs. Eagles Picks for Wild Card Weekend
Among several Wild Card Weekend player projections on PrizePicks, San Fran QB Brock Purdy and Philly RB Saquon Barkley are two names to highlight for 49ers vs. Eagles picks.
49ers QB Brock Purdy vs. Eagles Projection: 32 Passing Attempts
- As 6.5-point underdogs, the 49ers could find themselves in a negative game script, leading to more passing attempts. Purdy is 7-2 as a starter this season and averages 32.5 attempts in losses.
- San Francisco’s QB has reached 33 passing attempts in two of the last three outings.
- Pressure is possible given Philly’s talented defensive line, but Purdy carries a 79.4 PFF passing grade when under duress.
- The former Iowa State Cyclone is one of the league’s most efficient signal-callers, posting 0.23 EPA per play (third). Purdy could find some success, thus hinting at more passing tries.
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Eagles RB Saquon Barkley vs. 49ers Projection: 81.5 Rushing Yards
- Barkley’s production took a step back, falling from 125.3 rushing yards per game in 2024 to 71.3 this season. However, he’s averaging 100.0 rushing yards per contest since Week 14.
- The former Penn State Nittany Lion is racking up 4.9 yards per attempt over his last four, surpassing his 4.1 average on the year.
- Philadelphia’s halfback still has one of the NFL’s largest roles, carrying a 79.5% snap share (third) and 17.5 carries per contest (per PlayerProfiler).
- He’s logged 20.5 rushing attempts per contest since Week 14. With the Niners yielding 4.3 yards per carry (20th), Saquon’s hot streak could continue.
Make 49ers vs. Eagles Wild Card Picks on PrizePicks
The 49ers are dealing with key injuries, and the Eagles could have several advantages — including the turnover battle. In a potential negative game script, the world may be on Purdy’s shoulders. Can he do enough to help San Francisco pull off an upset win?
Make your Wild Card Round picks on PrizePicks for a chance to earn real-money rewards if you’re right. Just pick players and predict More or Less on their projected stats. You can make picks on the winner, spread, over/under, or futures on teams to make the playoffs on PrizePicks Team Picks — now available in 30 states.
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